Neuroserpin: A potential biomarker for early-onset severe preeclampsia

Perucci, Luíza Oliveira; Silva, Sirlaine Pio Gomes da; Bearzoti, Eduardo; Pinto, Kelerson Mauro de Castro; Alpoim, Patrícia Nessralla; Pinheiro, Melina de Barros; Godói, Lara Carvalho; Moraes, Lauro Ângelo Gonçalves de; Sousa, Lirlândia P.; Dusse, Luci Maria S.; Talvani, André

doi:10.1016/j.imbio.2023.152339

Cited by 1 publication

(2 citation statements)

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“…The IL-17A ( 58 ), IL-33 ( 59 ), CCL2 ( 60 ) and Neuroserpin ( 42 , 43 ) are maternal inflammatory markers released to the improvement of pregnancy outcomes, neurological and immunological development in fetuses in normal conditions, in the experimental models and human subjects. After recognition of T. gondii by the maternal immune system and, activation and recruitment of a new repertoire of inflammatory cells, a new inflammatory environment must be established by the release of a new set of inflammatory and regulatory mediators (including IL-17A, IL-33, CCL2 and neuroserpin), which are essential to contain parasites and, to mitigate the fetus infection ameliorating the prognosis of T. gondii -infected newborns ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

“…Neuroserpin is a serine protease inhibitor associated with synapse formation and neurogenesis, cellular adhesion and vascular permeability in the central nervous system, and inhibition of the tissue plasminogen activator, and acts as a protective factor against neurological disturbances (39)(40)(41)(42). In the context of gestation, neuroserpin has been proposed to be an important mediator in early-onset severe preeclampsia (43). Regarding DS, one study associated neuroserpin with the fibrinolytic system, which performs essential neurological functions.…”

Section: Discussionmentioning

confidence: 99%

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Neuroserpin, IL-33 and IL-17A as potential markers of mild symptoms of depressive syndrome in Toxoplasma gondii-infected pregnant women

Silva,

Toledo,

Pio

et al. 2024

Front. Immunol.

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IntroductionDepressive syndrome (DS) is a common complication during pregnancy and the postpartum period, and is triggered by multiple organic/genetic and environmental factors. Clinical and biochemical follow-up is essential for the early diagnosis and prognosis of DS. The protozoan Toxoplasma gondii causes infectious damage to the fetus during parasite primary-infection. However, in long-term infections, pregnant women develop immune protection to protect the fetus, although they remain susceptible to pathological or inflammatory effects induced by T. gondii. This study aimed to investigate plasma inflammatory biomarkers in pregnant women seropositive and seronegative for T. gondii, with diagnoses of minor and moderate/severe DS. MethodsPregnant women (n=45; age=18–39 years) were recruited during prenatal care at health centers in Ouro Preto, Minas Gerais, Brazil. Participants were asked to complete a socio-demographic questionnaire to be submitted to well-standardized DS scale calculators (Beck Depression Inventory Questionnaire, Edinburgh Postnatal Depression Scale, and Major Depressive Episode Module). Additionally, 4 mL of blood was collected for plasma neuroserpin, CCL2, IL-17A, and IL-33 analysis. ResultsPregnant volunteers with chronic T. gondii contact were all IgG+ (44%; n=21) and exhibited increased plasma IL-33, IL-17A, and neuroserpin levels, but not CCL2, compared to uninfected pregnant women. Using Beck’s depression inventory, we observed an increase in plasma IL-17A and IL-33 in women with T. gondii infeCction diagnosed with mild DS, whereas neuroserpin was associated with minor and moderate/severe DS. DiscussionOur data suggest a close relationship between DS in pregnant women with chronic T. gondii infection and neurological conditions, which may be partially mediated by plasma neuroserpin, IL-33, and IL-17A levels.

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