Neuroselective Current Perception Threshold Evaluation of Bladder Mucosal Sensory Function

Ukimura, Osamu; Ushijima, So; Honjo, Hisashi; Iwata, Takashi; Suzuki, Kei; Hirahara, Naoki; Okihara, Koji; Mizutani, Yoichi; Kawauchi, Akihiro; Miki, Tsuneharu

doi:10.1016/j.eururo.2003.08.004

Cited by 49 publications

(53 citation statements)

References 30 publications

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“…In one of the first applications of this technology in visceral organ, Ukimura and colleagues evaluated human bladder mucosal sensory function by obtaining CPT measures in healthy volunteers and patients with neuropathic bladders 12 . They showed quantitative neuroselective measurement of CPT values in the human bladder mucosal function was feasible.…”

Section: Discussionmentioning

confidence: 99%

“…The Neurometer® delivers sine-wave stimuli at frequencies of 2000, 250, and 5 Hz that have been shown to selectively stimulate large myelinated (Aβ), small myelinated (Aδ), and small unmyelinated (C) fibers, respectively 10,11 . This easy to conduct electro diagnostic procedure has been used in the evaluation of bladder sensory function in humans 12 . However, there is also interest in developing a method to evaluate bladder sensory function in experimental animals.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a Novel Device for Assessment of Autonomic Sensory Function in the Rat Bladder

et al. 2008

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Purpose-We developed and tested the efficacy of an implantable bladder device which, when combined with the Neurometer®, can be used to assess fiber-specific afferent sensation of the bladder in the rat.Materials and Methods-We developed an implantable bladder device which applies selective nerve fiber stimuli (250 Hz for small myelinated (Aδ), and 5 Hz for unmyelinated (C) fibers) to the bladder mucosa in the rat in order to obtain the bladder sensory perception threshold (SPT) values. We performed three experiments on fifty-five female Sprague-Dawley rats, examining the effects of our device on voiding habits; assessing the inter-observer reliability of SPT; and the effects of intravesical administration of resiniferatoxin and lidocaine on the SPT. Results-The SPT values obtained by two blinded, independent observers were not different from one another (p= 0.41). The SPT values obtained at both stimulation frequencies remained constant for at least 3 weeks after device implantation. A significant increase in SPT values after instillation of resiniferatoxin (p = 0.02) was noted at a stimulus frequency of 5 Hz, whereas intravesical lidocaine led to an immediate increase in SPT at both 250 and 5 Hz. Device implantation led to an early decreased voided volume and increased frequency of voids, however these parameters returned to normal after 4 days.Conclusions-Assessment of bladder afferent sensation with our newly developed device is feasible in rats, and provides sensory perception thresholds that appear to be fiber-type selective for autonomic bladder afferent nerves.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of a Novel Device for Assessment of Autonomic Sensory Function in the Rat Bladder

et al. 2008

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“…4,5 Diabetic bladder dysfunction is characterized as: 1) voiding difficulty, retention and bladder underactivity during urination; 6,7 and 2) infrequent voiding and reduced bladder sensation during urinary storage. 8,9 In addition recent surveys revealed the presence of overactive bladder (OAB) syndrome, describing it as urgency (complaint of a sudden compelling desire to pass urine which is difficult to defer), with or without incontinence, usually with urinary frequency and nocturia, 10 in a significant number of diabetic patients. 3,[11][12][13] Regarding pathophysiology of OAB in diabetes, OAB may well result from hyperosmorality and polydipsia due secondarily to hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

Overactive bladder in diabetes: A peripheral or central mechanism?

Yamaguchi

Sakakibara

Uchiyama

et al. 2007

Neurourology and Urodynamics

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“…The CPT evaluation was performed at the 3 frequencies, 2000 Hz, 250 Hz and 5 Hz, corresponding to evaluation of the Aβ, Aδ and C fibers 7,8) . In theory, the effect of TENS on each of these 3 types of fibers should be different since they represent three different neurophysiological mechanisms of pain 2) .…”

Section: Discussionmentioning

confidence: 99%

“…A commonly used CPT device is the Neurometer NS3000 (Neurotron Inc., Baltimore, Maryland, USA) which employs a constant alternating sinusoidal current to deliver electrical stimulus at frequencies of 2000, 250 and 5 Hz 7) . It has been reported that these 3 frequencies can selectively stimulate, and therefore assess, the large myelinated Aβ fibers, the small myelinated Aδ fibers, and the unmyelinated C fibers, respectively 7,8) . Since CPT devices are usually constant current stimulators, skin impedance is not a limiting factor and the results are unaffected by skin temperature, skin thickness or elasticity 9) .…”

Section: Introductionmentioning

confidence: 99%

A Descriptive Study Investigating the Feasibility and Selectivity of Current Perception Threshold in the Objective Assessment of Post-operative Sub-acute Knee Pain

et al. 2013

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Abstract.[Purpose] The aim of this study was to investigate the feasibility of using the current perception threshold (CPT), in a comparison with the visual analog scale (VAS), to assess its selectivity in assessing the excitability of Aβ, Aδ and C fibers in subjects with sub-acute post-operative pain who were being treated with conventional transcutaneous electrical nerve stimulation (TENS). [Subjects and Methods] A total of 17 subjects (mean age of 29.2 ±10.8 years) participated in this study. For all subjects, the study commenced on the fifth post-operative day and continued for the next five consecutive days following a descriptive time-series design. Both CPT and VAS were measured for all subjects on all five days following 15 minutes rest with the TENS output intensity set at zero on the baseline days (Days 1, 3, 5), and after 15 minutes TENS stimulation on the intervention days (Days 2 and 4).[Results] The results demonstrate that CPT was able to selectively assess the excitability of the Aβ and Aδ fibers. However, the selectivity of CPT in assessing the C fibers could not be verified in this study.[Conclusion] The various limitations of the time series design used in this study suggest the need to verify some of these results in a different experimental design in future studies.

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Neuroselective Current Perception Threshold Evaluation of Bladder Mucosal Sensory Function

Cited by 49 publications

References 30 publications

Efficacy of a Novel Device for Assessment of Autonomic Sensory Function in the Rat Bladder

Efficacy of a Novel Device for Assessment of Autonomic Sensory Function in the Rat Bladder

Overactive bladder in diabetes: A peripheral or central mechanism?

A Descriptive Study Investigating the Feasibility and Selectivity of Current Perception Threshold in the Objective Assessment of Post-operative Sub-acute Knee Pain

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