Child parent relationship therapy (CPRT) focuses on improving the parent-child relationship, helping children by teaching parents to be therapeutic agents in their children's lives. A primary element of CPRT is the supportive group format of 6Ϫ8 parents that includes elements of didactic learning and group support. The information in this article serves as a foundation for the use of interpersonal neurobiology (IPNB) in CPRT groups. The application of IPNB in specific areas of counseling related to CPRT including counselor education, play therapy, group therapy, and psychoeducation is still new but shows promise for understanding and improving counseling. IPNB can be utilized as a vehicle for gaining a deeper understanding of the therapeutic mechanisms of CPRT, and IPNB can be intentionally integrated into CPRT group curriculum to enhance learning for group members and their children.