Neurosarcoidosis with Intraparenchymal Cystic Lesions

Hajri, F.A. Al; Muqim, Abdulaziz T.; Muttikkal, Thomas Jose Eluvathingal

doi:10.1177/197140090802100610

Cited by 3 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another patient, presenting with generalized tonic-clonic-seizures, had progressively enlarging cystic lesions expanding into the right temporal lobe on MRI and abnormal enhancing lesions on CT scan. Urgent biopsy revealed sarcoidosis with neurological infiltration [29]. These two patients illustrate that neurosarcoidosis, similar to typical sarcoidosis, can present with complex findings that can be further clouded by imaging.…”

Section: Neurosarcoidosismentioning

confidence: 85%

Sarcoidosis of the Head and Neck

Badhey

Kadakia

Carrau

et al. 2014

Head and Neck Pathol

View full text Add to dashboard Cite

Sarcoidosis is a complex disorder that often times involves the head and neck. Despite the presence of strong clinical evidence, tissue diagnosis and imaging is needed for confirmation of the disease. Although typically managed medically, when found in the sinonasal tract or intracranially, it may necessitate the intervention of a rhinologist-skull base surgeon. This article seeks to provide a comprehensive review of head and neck sarcoidosis, as this fascinating disorder often poses a diagnostic and therapeutic challenge. A brief discussion of surgical treatment for pituitary lesions is also provided. Articles from 1997 to 2013 were selected and reviewed by three researchers utilizing the most recent literature regarding sarcoidosis in the head and neck. PubMed searches were conducted using search terms such as "sarcoidosis", "neurosarcoid", and "extra-pulmonary sarcoid", among many others. A large collection of articles was generated and reviewed by the team of authors, and appropriate information was extracted to compose a thorough and expansive review of the subject. 10-15 % of patients with sarcoidosis have head and neck manifestations. Sinonasal and pituitary sarcoidosis presents a diagnostic challenge owing to its non-specific symptoms. Although systemic steroid therapy is often the first time treatment, endoscopic surgery is commonly used to treat advanced pituitary sarcoidosis refractory to medical management. As tissue diagnosis and imaging is key, a multi-disciplinary team approach is advantageous. Our study collates the available literature on head and neck sarcoidosis to provide a comprehensive review of the subject. This provides helpful information to guide all practitioners involved in the care of these challenging patients, namely pathologists, radiologists, otolaryngologists, and skull base surgeons, in the workup and management of head and neck sarcoidosis.

show abstract

Section: Neurosarcoidosismentioning

confidence: 85%

Sarcoidosis of the Head and Neck

Badhey

Kadakia

Carrau

et al. 2014

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

Guillain-Barré Syndrome Associated with Acute Onset Bilateral Facial Nerve Palsies

et al. 2012

View full text Add to dashboard Cite

Guillain-Barré syndrome is a post infectious, immune-mediated disease with cranial nerve involvement observed in 45-75% of patients. Bilateral facial nerve palsy is rather uncommon and occurs in 0.3% to 2% of all facial palsies. We describe a rare case of a 29-year-old man with bilateral facial palsy caused by a Guillain-Barré syndrome with an unusual onset and progression of neurological symptoms. Neuroradiological findings in our patient are described and compared with data from literature on bilateral facial palsies to make differential diagnosis easier for neuroradiologists.

show abstract

Unique imaging appearance of neurosarcoidosis as a solitary cystic mass with mural enhancement

Bathla

Kandemirli

Gupta

et al. 2020

Surgical Neurology International

View full text Add to dashboard Cite

Background: Sarcoidosis is an idiopathic, granulomatous, and multi-system inflammatory disorder that can also involve the central nervous system in the form of meningeal, parenchymal, or cranial nerve involvement. Imaging findings can be non-specific and may overlap with other inflammatory, infectious and neoplastic processes, and posing diagnostic challenges. Parenchymal involvement in neurosarcoidosis (NS) predominantly manifests as either non-enhancing white matter lesions or as enhancing parenchymal granulomas. Granulomas usually manifest as multiple solid lesions with nodular enhancement. Case Description: A 72-year-old man presented with right-eye visual field changes with the non-contrast head computed tomography showing a large cystic lesion in the left frontoparietal lobe. Subsequent contrast-enhanced magnetic resonance imaging study revealed a large cystic mass with irregular rim enhancement and mural nodule concerning for glial neoplasm. Cyst decompression with biopsy and histopathological analysis revealed gliosis and prominent perivascular granulomatous inflammation with mixed picture of CD4 and CD8-positive cells suggestive of sarcoidosis. Further subsequent work-up showed mediastinal and cervical lymphadenopathy which on biopsy showed non-necrotizing granulomatous inflammation, consistent with sarcoidosis. Conclusion: Herein, we report unique imaging findings of a NS case manifesting as a solitary cystic intraparenchymal lesion with an enhancing nodular component, mimicking primary intra-cranial tumor. This appearance is highly atypical and rarely been reported earlier.

show abstract

Neurosarcoidosis with Intraparenchymal Cystic Lesions

Cited by 3 publications

References 28 publications

Sarcoidosis of the Head and Neck

Sarcoidosis of the Head and Neck

Guillain-Barré Syndrome Associated with Acute Onset Bilateral Facial Nerve Palsies

Unique imaging appearance of neurosarcoidosis as a solitary cystic mass with mural enhancement

Contact Info

Product

Resources

About