Neuroretinal degeneration in a mouse model of systemic chronic immune activation observed by proteomics
Asif Manzoor Khan,
Maria Abildgaard Steffensen,
Egle Paskeviciute
et al.
Abstract:Blindness or vision loss due to neuroretinal and photoreceptor degeneration affects millions of individuals worldwide. In numerous neurodegenerative diseases, including age-related macular degeneration, dysregulated immune response-mediated retinal degeneration has been found to play a critical role in the disease pathogenesis. To better understand the pathogenic mechanisms underlying the retinal degeneration, we used a mouse model of systemic immune activation where we infected mice with lymphocytic choriomen… Show more
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