Neurorestorative Mulberries Potential of Alzheimer’s Disease in Animal Model

El-Baz, Farouk; Aly, Hanan F.; Ali, Sanaa A.

doi:10.22159/ajpcr.2018.v11i10.27155

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…According to the data manipulated in Figure 10, the behavioral test results agree with previously obtained results, which demonstrated that AlCl 3 -neurointoxicated rats took more time to catch food in a T-maze, denoting deteriorated neurocognitive function [25]. Whereas OEP extract showed a significant decrease in time taken by rats to reach food in the T-maze, in comparison to the AD-induced group, indicating improved cognitive abilities.…”

Section: Discussionsupporting

confidence: 88%

The Protective and Therapeutic Anti-Alzheimer Potential of Olea europaea L. cv. Picual: An In Silico and In Vivo Study

et al. 2022

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LC-HRESIMS metabolomic profiling of Olea europaea L. cv. Picual (OEP) (Saudi Arabian olive cultivar, F. Oleacea) revealed 18 compounds. Using pharmacology networking to specify the targets of the identified compounds with a relationship to Alzheimer’s disease, it was possible to identify the VEGFA, AChE, and DRD2 genes as the top correlated genes to Alzheimer’s disease with 8, 8, and 6 interactions in the same order. The mechanism of action on cellular components, biological processes, and molecular functions was determined by gene enrichment analysis. A biological pathway comparison revealed 13 shared pathways between the identified genes and Alzheimer protein genes (beta-amyloid band tau proteins). The suggested extract’s anti-Alzheimer potential in silico screening was confirmed through in vivo investigation in regressing the neurodegenerative features of Alzheimer’s dementia in an aluminum-intoxicated rat model (protective and therapeutic effects, 100 mg/kg b.w.). In vivo results suggested that OEP extract significantly improved Alzheimer’s rats, which was indicated by the crude extract’s ability to improve T-maze performance; lower elevated serum levels of AChE, AB peptide, and Ph/T ratio; and normalize the reduced level of TAC during the study. The results presented in this study may provide potential dietary supplements for the management of Alzheimer’s disease.

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Section: Discussionsupporting

confidence: 88%

The Protective and Therapeutic Anti-Alzheimer Potential of Olea europaea L. cv. Picual: An In Silico and In Vivo Study

et al. 2022

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“…That aside, M. alba fruit extract has significantly reversed the AlCl 3 neurotoxin-induced alteration of striatum neurotransmitters and decreased 50% of acetylcholinesterase (AChE) activity in the brain. A significant increment in norepinephrine, epinephrine, 5-hydroxytryptamine serotonin, and dopamine neurotransmitter were observed in the treated mice [ 81 ]. Based on these data, M. alba could attenuate Alzheimer’s disease via Aβ deposition alleviation, inflammatory-factor reduction, and BDNF/TrkB signaling pathway alleviation, thus proving their protective effects on memory and learning abilities.…”

Section: Nutraceutical Properties Of Morus Albamentioning

confidence: 99%

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient

Chen

Razali

Saikim

et al. 2021

Foods

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Morus alba L. (M. alba) is a highly adaptable plant that is extensively incorporated in many traditional and Ayurveda medications. Various parts of the plant, such as leaves, fruits, and seeds, possess nutritional and medicinal value. M. alba has abundant phytochemicals, including phenolic acids, flavonoids, flavonols, anthocyanins, macronutrients, vitamins, minerals, and volatile aromatic compounds, indicating its excellent pharmacological abilities. M. alba also contains high nutraceutical values for protein, carbohydrates, fiber, organic acids, vitamins, and minerals, as well as a low lipid value. However, despite its excellent biological properties and nutritional value, M. alba has not been fully considered as a potential functional food ingredient. Therefore, this review reports on the nutrients and bioactive compounds available in M. alba leaves, fruit, and seeds; its nutraceutical properties, functional properties as an ingredient in foodstuffs, and a microencapsulation technique to enhance polyphenol stability. Finally, as scaling up to a bigger production plant is needed to accommodate industrial demand, the study and limitation on an M. alba upscaling process is reviewed.

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“…In previous study, the level of NA are depressed in the cortex and cerebellum of animals have administered low copper or high aluminum [38] .β-amyloid (Aβ) plaques were mostly made of aggregated Aβ proteins and neurofibrillary tangles (NFTs) formed by hyper phosphorylated tau protein. Aβ induces neurotoxicity through induction of apoptosis and inflammation, disruption of calcium homeostasis, oxidative stress, and activation of complement [39].…”

Section: Discussionmentioning

confidence: 98%

GC/MS analysis of Egyptian Clementine oil and efficacy on Alzheimer’s disease –induced rats

et al. 2021

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Essential oils have been used as remedies since ancient times for the treatment of numerous illnesses on account of their wide range of biological activities. Varying pharmacological responses in the nervous system leading to anxiolytic, antidepressant, sedative, and anticonvulsant effects. This research aims to extract oil from Egyptian Clementine by Screw Press to improve the properties of producing oil and to evaluate the effect of it on Alzheimer's disease (AD) in rats -induced by AlCl3. The maximum yield of Clementine oil was about 11 %, healthy and low fatty acid at screw temperatures 40°C and motors speed 25 rpm. The fatty acid composition was analysed by GC/MS. In In vivo experiment ; AD-induced rats were orally administered 100mg/kg b.wt of AlCl3 for two months. Clementine oil was administered at a dose of 100 ul /kg b.wt. for 6 weeks compared to reference drug donepezil 10 mg/kg b.wt.. Acetylcholine esterase (AchE), Acetylcholine (Ach), ,noradrenaline (NA), adrenaline (AD),serotonin (5-HT),oxidative stress marker ;malondialdehyde (MDA), superoxide dismutase (SOD),catalase (CAT),total antioxidant capacity (TAC), tau protein and β-amyloid were estimated in brain tissue and serum of AD-induced rats and therapeutic group compared to control. Histological investigation of hippocampal of AD rats revealed severe neuropathologic damage exhibited by shrunken and necrosis of pyramidal neurons associated with the formation of neurofibrillary tangles, the proliferation of glia cells, and neuronophagia. Strong immune reactivity of hypertrophied astrocytes with deeply brown stained GFAP positive processes was noticed in the cerebral cortex and hippocampus of AD rats. The hippocampus of rats treated with reference drug revealed necrosis of some pyramidal neurons and neurofibrillary tangles. However, rats treated with oil showed marked restoration of the histological structure with only sporadic necrosis of pyramidal neurons. The cerebral cortex showed numerous neuropathologic alterations described by psychosis and necrosis of neurons as well as the formation of neurofibrillary tangles and focal gliosis. Further, oil treatment exhibited regression of the histopathological damage. While down-regulation of the immune GFAP immune reaction was seen in the cortex and hippocampus of rats treated with either reference drug or oil. Additionally, noticeable improvement was detected in all measured biochemical parameters upon treated AD-induced rats with Clementine oil. It could be concluded that remarkable improvement in all detected parameters resulting from treatment of AD rats with Clementine oil extracted by Screw press techniques due to its high antioxidant activity. Essential oils (Eos) has shown anticholinesterase activity, which might be advantageous for the development of drugs for AD treatment since cholinesterase has been recognized as one of its potential targets.

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Neurorestorative Mulberries Potential of Alzheimer’s Disease in Animal Model

Cited by 6 publications

References 25 publications

The Protective and Therapeutic Anti-Alzheimer Potential of Olea europaea L. cv. Picual: An In Silico and In Vivo Study

The Protective and Therapeutic Anti-Alzheimer Potential of Olea europaea L. cv. Picual: An In Silico and In Vivo Study

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient

GC/MS analysis of Egyptian Clementine oil and efficacy on Alzheimer’s disease –induced rats

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