Neuroradiology of central neurocytoma

Wichmann, W.; Schubiger, O; Deimling, Andreas von; Schenker, C; Valavanis, Anton

doi:10.1007/bf00588253

Cited by 70 publications

(38 citation statements)

References 20 publications

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“…Contrast enhancement is mild to moderate for most central neurocytomas. MR imaging usually reveals a mass that is isointense in T1-weighted images [6,7,39]. In T2-weighted images, most central neurocytomas are relatively isointense with cortex.…”

Section: Radiologymentioning

confidence: 99%

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Chen¹,

Shen²,

Wang³

et al. 2008

Clinical Neurology and Neurosurgery

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Purpose-Central neurocytoma is a rare intraventricular brain tumor that affects young adults and presents with increased intracranial pressure secondary to obstructive hydrocephalus. Typically, it has a favorable prognosis after adequate surgical intervention, but in some cases the clinical course is more aggressive. In this report, we describe the diagnosis and treatment of central neurocytoma in a series of patients at our institution.Patients and Methods-Our series of nine patients (M:F=2:7, mean age, 28.2 years) with ventricular tumors showed typical radiological, histologic and immunohistochemical features of central neurocytoma. Most patients received craniotomy with removal of the tumor through transcallosal or transcortical approach. The surgical and histopathologic data of these patients were reviewed and analyzed.Results-The prognosis is generally favorable. Although most patients were alive and well at the last follow-up, two developed recurrence. Typical histologic features of recurrent neurocytoma include high proliferative activity (MIB-1 labeling index: 2.0-6.8%), prominent vascular proliferation and remarkable synaptophysin expression. Two patients (non-recurrent) died during follow-up due to sepsis or central failure. The MIB-1 labeling indices were as high as 2.2-5.4% for these two patients.Conclusion-Although central neurocytoma is generally a benign neoplasm, some variant forms of recurrence are also present. Complete resection provides favorable long-term prognosis in most cases. Recurrent tumors are often local and the patients seem to recover well after a second resection followed by radiotherapy. Histologic features such as tumor proliferation (MIB-1 labeling index), vascular proliferation, and synaptophysin expression are often prominent in the recurrent tumor. We recommend that these histologic features be considered for tumor recurrence during treatment and follow-up of these patients.

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Section: Radiologymentioning

confidence: 99%

Central neurocytoma: A clinical, radiological and pathological study of nine cases

Chen¹,

Shen²,

Wang³

et al. 2008

Clinical Neurology and Neurosurgery

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“…Wichmann et al's study 25 ) and may correlate with the compact regularity of tumor cell arrangement seen in both EVN and CN. This hypothesis may be further supported by the increased signal intensity of these 2 tumor types on DWI, 7,26 for attenuated cellularity of tumor tissue may lead to restricted diffusion according to previous studies.…”

Section: Discussionmentioning

confidence: 85%

MR Imaging of Cerebral Extraventricular Neurocytoma: A Report of 9 Cases

Liu¹,

Wen²,

Lv³

et al. 2012

AJNR Am J Neuroradiol

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SUMMARY: Extraventricular neurocytoma is a rare entity, most frequently occurring in brain parenchyma outside the ventricular system. The purpose of this study was to characterize the MR imaging findings in a series of 9 patients with EVN verified by results of pathologic examination. All 9 EVNs were solitary and intracranially located. Eight lesions were well demarcated, and 3 showed intratumoral hemorrhage. The solid parts of 7 tumors were primarily isointense on T1-weighted images and heterogeneously enhanced on T1WI with contrast. Although cerebral EVNs can present a wide spectrum of appearances on MR, the imaging patterns appear to vary according to anatomic location and cellularity. Lesions in frontal or parietal lobes often present as well-demarcated large masses with cystic degeneration, hemorrhage, mild-to-moderate edema, and inhomogeneous enhancement. Moreover, the general isointensity of the solid parts of EVN on T1WI may be of some specificity.

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“…The MR findings of all 13 patients are summarized in the Table. 1, 3, 6, [14][15][16][17][18][19][20]24). Central neurocytoma exhibits immunoreactivity for neuron-specific enolase and synaptophysin, indicating neuronal differentiation.…”

Section: Resultsmentioning

confidence: 99%

“…To our knowledge, CT findings of approximately 40 cases of central neurocytoma have been reported (1,3,6,8,9,1617,19,20,24). MR imaging findings, however, have been described in relatively few reports (3,6,17,19,20,24). The purpose of this paper is to provide a detailed description of the MR appearance of central neurocytoma and to compare the MR findings with those on CT.…”

mentioning

confidence: 97%