Neuropsychological tests with lateralizing value in patients with temporal lobe epilepsy: Reconsidering material-specific theory

Raspall, Toni; Doñate, Marta; Boget, Teresa; Carreño, Mar; Donaire, Antonio; Agudo, Rolando; Bargalló, Núria; Rumià, Jordi; Setoaín, Xavier; Pintor, Luís; Salamero, Manel

doi:10.1016/j.seizure.2005.09.007

Cited by 52 publications

(40 citation statements)

References 38 publications

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“…Another explanation for the lack of association between loss of CB expression in granule cells and the visual memory deficit can be that visual tasks are less sensitive than verbal tasks. Generally, verbal memory deficits of patients with left TLE are more consistent and robust than non-verbal memory deficits in patients with right TLE [77][78][79].…”

Section: Discussionmentioning

confidence: 93%

Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy

Karádi

Janszky

Gyimesi

et al. 2012

Epilepsy & Behavior

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Section: Discussionmentioning

confidence: 93%

Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy

Karádi

Janszky

Gyimesi

et al. 2012

Epilepsy & Behavior

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“…Independently, irrespective of whether these are two different syndromes, the presence of hippocampal atrophy (HA) in both subgroups enables comparisons between MTLE patients with HA with different seizure frequencies, allowing us to investigate the influence of the seizure frequency on several clinical features, especially on cognitive performance, one of the major complaints …”

mentioning

confidence: 99%

Memory impairment is not necessarily related to seizure frequency in mesial temporal lobe epilepsy with hippocampal sclerosis

et al. 2014

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SUMMARYObjective: To investigate the effect of seizure frequency on memory, we performed a cross sectional study comparing mesial temporal lobe epilepsy (MTLE) patients with frequent and infrequent seizures. Methods: We performed magnetic resonance imaging (MRI) hippocampal volume (HV) measurements and neuropsychological assessment in 22 patients with frequent seizures (at least one dyscognitive seizure [DS] per month) that were refractory to antiepileptic drugs and 20 patients with infrequent seizures (three or less DS per year and no event evolving to a bilateral convulsive seizure), all with MRI signs of hippocampal sclerosis (HS) on visual analysis. We also included 29 controls for comparison of volumetric data. Results: There was no difference in memory performance between patients with frequent seizures and infrequent seizures. We observed a significant bilateral reduction of HV in patients with MTLE when compared to controls (p < 0.001). The degree of hippocampal atrophy (HA) between patients with frequent and infrequent seizures was not different. There was a negative correlation between seizure frequency and HV, with r = À0.3 for the HV ipsilateral to the HS and r = À0.55 for the contralateral side, thus, explaining only 9% and 30% of the HV loss. There was a positive correlation between age of onset and degree of HA (r = 0.37). Significance: Our data suggest that seizure frequency does not explain most of the HV loss or memory impairment in MTLE. Memory impairment appears to be more influenced by hippocampal damage than by seizure frequency. Further studies are necessary to identify the factors that influence memory decline in patients with MTLE.

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“…Numerous investigators have reported significant confrontation naming impairments in DOM TLE patients (Mayeux et al, 1980; Hermann et al, 1992; Howell et al, 1994; Hermann et al, 1997; Hamberger and Tamny, 1999; Hermann et al, 1999a; Bell et al, 2001; Schefft et al, 2003; Oyegbile et al, 2004; Raspall et al, 2005; Busch et al, 2005; Fargo et al, 2005); however, several other studies have failed to find this between‐group difference (Hermann and Wyler, 1987; Stafniak et al, 1990; Hermann et al, 1991; Langfitt and Rausch, 1996; O'Shea et al, 1996). Till now, exclusively quantitative methods by which to evaluate confrontation naming ability have produced mixed results.…”

Section: Discussionmentioning

confidence: 99%

Interictal and Postictal Language Testing Accurately Lateralizes Language Dominant Temporal Lobe Complex Partial Seizures

Ramirez¹,

Schefft²,

Howe³

et al. 2007

Epilepsia

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SUMMARYPurpose: Noninvasive tests that accurately localize seizure onset provide great value in the presurgical evaluation of patients with intractable epilepsy. This study examined the diagnostic utility of three expressive language disturbances in lateralizing language-dominant (DOM) temporal lobe complex partial seizures: (1) the postictal language delay (PILD; time taken to correctly read a test phrase out loud immediately following seizures); (2) the production of postictal phonemic paraphasic errors (PostPE); and (3) interictal phonemic paraphasic errors (InterPE). Methods: All 60 subjects underwent inpatient video/EEG monitoring and had surgically confirmed temporal lobe epilepsy (TLE). We determined the presence and number of PostPE and, PILD times (in s) for 212 seizures, and InterPE on the Boston Naming Test (BNT). Each technique's diagnostic usefulness was evaluated via logistic regression and ROC curve analysis. Sensitivity, specificity, positive predictive value and negative predictive values were computed. Results: PILD, PostPE and InterPE production were equally effective and accurate in lateralizing DOM seizure onset. Patients with DOM TLE had a longer PILD and committed more PostPE and InterPE than those with nondominant (NDOM) TLE. Respective sensitivity and specificity values were as follows: PILD (84%, 86%), PostPE (94%, 64%), and InterPE (97%, 86%). No single predictor was significantly better but a combination model yielded enough incremental utility to collectively outperform each separate predictor model. Conclusions: Interictal language testing is as accurate as postictal language testing in predicting DOM lateralization of TLE. Clinicians should also attend to the quality of errors produced during interictal and postictal language testing. KEY WORDS: Paraphasic error, postictal language delay, Epilepsy, Confrontation naming, Confrontation naming, Postictal language testing.Noninvasive methods that can localize or lateralize the epileptogenic focus are preferred in the evaluation of epilepsy surgery candidates. Prior studies have shown that postictal and interictal language disturbances can accu-

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Neuropsychological tests with lateralizing value in patients with temporal lobe epilepsy: Reconsidering material-specific theory

Abstract: Language measures predict the side of seizure focus better than memory measures. The results of this study in a sample of drug-resistant temporal lobe epilepsy patients challenge the memory material-specific theory for the side of seizure focus.

Cited by 52 publications

References 38 publications

Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy

Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy

Memory impairment is not necessarily related to seizure frequency in mesial temporal lobe epilepsy with hippocampal sclerosis

Interictal and Postictal Language Testing Accurately Lateralizes Language Dominant Temporal Lobe Complex Partial Seizures

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