Neuropsychological Test Performance of Pediatric Cancer Patients at Diagnosis and One Year Later

Copeland, Donna R.; Dowell, Richard E.; Fletcher, Jack Μ.; Sullivan, Margaret P.; Jaffe, Norman; Cangır, Ayten; Frankel, Lawrence S.; Judd, Brian W.

doi:10.1093/jpepsy/13.2.183

Cited by 48 publications

(31 citation statements)

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“…A number of studies have demonstrated the feasibility of neuropsychological assessment within weeks of ALL diagnosis [Copeland et al, 1988;Brown et al, 1996;Jansen et al, 2005]. Although one expects large groups of children to have mean IQ scores that approximate the population mean of 100, ALL patients tend to obtain IQ scores above 100 when assessed within weeks of diagnosis.…”

Section: Methodological Issuesmentioning

confidence: 99%

“…Although one expects large groups of children to have mean IQ scores that approximate the population mean of 100, ALL patients tend to obtain IQ scores above 100 when assessed within weeks of diagnosis. Baseline IQs range from 99 to 115 with Performance IQ slightly higher than verbal IQ in most cases [Soni et al, 1975;Stehbens and Kisker, 1984;Copeland et al, 1988;Brown et al, 1996;Jansen et al, 2005Jansen et al, , 2006Nathan et al, 2006;Carey et al, 2007]. Furthermore, siblings of ALL patients exhibit mean full scale IQs near 110 [Moss et al, 1981;Jannoun, 1983;Twaddle et al, 1983;Taylor et al, 1987;Giralt et al, 1992;Jansen et al, 2005].…”

Section: Methodological Issuesmentioning

confidence: 99%

“…This is evident on tests of intelligence and more specific neuropsychological processes [Copeland et al, 1988;Schlieper et al, 1989;Anderson et al, 1994;Jankovic et al, 1994;Harila-Saari et al, 1998;Schatz et al, 2000;Kingma et al, 2001;Langer et al, 2002;Spiegler et al, 2006]. In a meta-analysis of 28 studies, Campbell et al [2007] found that children treated with protocols including CR had lower IQs than those receiving CO alone.…”

Section: Radiation Versus Chemotherapy-onlymentioning

confidence: 99%

“…On-treatment studies IQ scores of children on active CO treatment are at least average [Williams et al, 1986;MacLean et al, 1995;Krappman et al, 2007;Moore et al, 2008], with no evidence of decline over the course of treatment [Copeland et al, 1988;Dowell et al, 1989;Brown et al, 1996;Copeland et al, 1996;Carey et al, 2007]. However, difficulties with perceptual motor speed [Copeland et al, 1988[Copeland et al, , 1996, working memory [Carey et al, 2007], academic achievement [Brown et al, 1996], and fine motor skills [Dowell et al, 1989;Hockenberry et al, 2007] have been reported.…”

Section: Chemotherapy-onlymentioning

confidence: 99%

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Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment

Janzen

Spiegler

2008

Dev Disabil Res Revs

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This review will describe the neurocognitive outcomes associated with pediatric acute lymphoblastic leukemia (ALL) and its treatment. The literature is reviewed with the aim of addressing methodological issues, treatment factors, risks and moderators, special populations, relationship to neuroimaging findings, and directions for future research. It is concluded that neurocognitive outcomes for the majority of children with standard-risk ALL treated according to current chemotherapy protocols is relatively good, but subgroups of children are more significantly compromised. As medical treatments advance and survival rates continue to improve, neurocognitive outcomes and other quality of life indicators will become increasingly important. Preventing or ameliorating treatment-related neuropsychological sequelae represents the next major challenge in pediatric ALL.

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Section: Methodological Issuesmentioning

confidence: 99%

Section: Methodological Issuesmentioning

confidence: 99%

Section: Radiation Versus Chemotherapy-onlymentioning

confidence: 99%

Section: Chemotherapy-onlymentioning

confidence: 99%

See 2 more Smart Citations

Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment

Janzen

Spiegler

2008

Dev Disabil Res Revs

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“…These less toxic treatment protocols have sometimes 8,15 but not always resulted in reduced negative cognitive or psychologic outcomes. [16][17][18] Variation in dose of MTX and combinations of CNS radiation with MTX may be important factors in the equivocal data across studies.…”

mentioning

confidence: 99%

Impact of CNS Treatment on Mood in Adult Survivors of Childhood Leukemia: A Report From the Children’s Cancer Group

Glover

Byrne

Mills

et al. 2003

JCO

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Purpose-This study assessed the relationship between CNS treatment and psychologic mood using the Profile of Moods State (POMS), a standardized measure of affect, among a large sample of young adult survivors of childhood acute lymphoblastic leukemia (ALL; N = 555).Patients and Methods-Survivors of childhood ALL (ages 18 to 33 years at study entry) participated in a structured telephone interview eliciting demographic, health, and behavioral data and the POMS. Treatment data included total dose of CNS irradiation (CRT) and intrathecal methotrexate (MTX) obtained from medical records.Results-Mood disturbance was reported by 24% of survivors. High-dose CRT and MTX predicted disturbance rates modestly and primarily in combination with education variables. Interactions between educational achievement, a history of attendance in special education classes, and sex were better predictors than treatment type or dose. Non-white males, those younger than 12.5 years of age at diagnosis, and those with negative perceptions of current health and cancer's impact on employment were also at greater risk for mood disturbance (P < .01 to .001).Conclusion-Although most survivors are doing well psychologically, a subset of long-term survivors show potentially serious mood disturbance. Mood disturbance seems to be a function of interactions between preexisting individual difference variables (eg, sex, race/ethnicity), treatment factors, and posttreatment educational experiences. Prevention strategies aimed at childhood cancer survivors at greatest risk for mood disturbance may be improved by focus on posttreatment psychosocial and educational supports.RESEARCH ON survivors of childhood acute lymphoblastic leukemia (ALL) suggests that as expected survival time after treatment for ALL increases, the risk of neuropsychologic and psychosocial impairments in functioning may increase. 1,2 Although many survivors of Compared with other treatments, high-dose cranial radiation treatment (CRT) has been linked to lower intelligence quotient levels, 9 poor academic performance, 10 an increase in learning problems in school, 11 and a reduced likelihood of attending college as survivors become young adults. 12 Even low-dose CRT has been associated with mild delayed intelligence quotient decline, increased learning disabilities, and academic failure. 13-15 As concerns about the excessive toxicity of CNS radiation emerged, treatment protocols were shifted to include increasing doses of intrathecal (IT) methotrexate (MTX) chemotherapy and less CRT. These less toxic treatment protocols have sometimes 8,15 but not always resulted in reduced negative cognitive or psychologic outcomes. 16-18 Variation in dose of MTX and combinations of CNS radiation with MTX may be important factors in the equivocal data across studies.The relative benefit of MTX compared with CRT may also depend on demographic variables, such as age and sex. Treatment with CNS radiation at a young age may place survivors at greatest risk for neuropsychologic impairment. 2,13,14...

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Neurophysiological Basis of Cognitive Deficits in Long-term Survivors of Childhood Cancer

Moore¹,

Copeland²,

Ried³

1992

Archives of Neurology

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Neuropsychological Test Performance of Pediatric Cancer Patients at Diagnosis and One Year Later

Cited by 48 publications

References 0 publications

Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment

Neurodevelopmental sequelae of pediatric acute lymphoblastic leukemia and its treatment

Impact of CNS Treatment on Mood in Adult Survivors of Childhood Leukemia: A Report From the Children’s Cancer Group

Neurophysiological Basis of Cognitive Deficits in Long-term Survivors of Childhood Cancer

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