Neuropsychological profiles and neural correlates in typical and atypical variants of Alzheimer disease: A systematic qualitative review

Fredes-Roa, Claudia; Gutiérrez-Barría, Felipe; Ramírez-Bruna, Cristina; Cigarroa, Igor; Martella, Diana; Julio-Ramos, Teresa; Méndez-Orellana, Carolina; Toloza-Ramírez, David

doi:10.1016/j.neurop.2022.07.007

Cited by 1 publication

(1 citation statement)

References 151 publications

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“…However, several studies report that AD is not a homogeneous entity, describing four atypical or non-amnestic forms (i.e., logopenic variant primary progressive aphasia (lvPPA), posterior cortical atrophy (PCA), behavioral/dysexecutive variant (bvAD), and corticobasal syndrome (CBS). These forms differ from typical AD in age of onset and clinical presentation and may be related to underlying biological subtypes [ 176 , 177 ]. For this reason, a comprehensive clinical history and neuropsychological assessment focusing on orientation, attention, language, praxis, memory, visuospatial skills, gnosis, and executive function are critical to characterize the patient’s cognitive presentation and differentiate it from the typical profiles of various diseases [ 178 ].…”

Section: Neuropsychological Assessment and Differential Diagnosis Of ...mentioning

confidence: 99%

Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights

Alzola,

Carnero,

Bermejo-Pareja

et al. 2024

JCM

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Dementia remains an underdiagnosed syndrome, and there is a need to improve the early detection of cognitive decline. This narrative review examines the role of neuropsychological assessment in the characterization of cognitive changes associated with dementia syndrome at different states. The first section describes the early indicators of cognitive decline and the major barriers to their identification. Further, the optimal cognitive screening conditions and the most widely accepted tests are described. The second section analyzes the main differences in cognitive performance between Alzheimer’s disease and other subtypes of dementia. Finally, the current challenges of neuropsychological assessment in aging/dementia and future approaches are discussed. Essentially, we find that current research is beginning to uncover early cognitive changes that precede dementia, while continuing to improve and refine the differential diagnosis of neurodegenerative disorders that cause dementia. However, neuropsychology faces several barriers, including the cultural diversity of the populations, a limited implementation in public health systems, and the adaptation to technological advances. Nowadays, neuropsychological assessment plays a fundamental role in characterizing cognitive decline in the different stages of dementia, but more efforts are needed to develop harmonized procedures that facilitate its use in different clinical contexts and research protocols.

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Section: Neuropsychological Assessment and Differential Diagnosis Of ...mentioning

confidence: 99%

Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights

Alzola,

Carnero,

Bermejo-Pareja

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

Neuropsychological profiles and neural correlates in typical and atypical variants of Alzheimer disease: A systematic qualitative review

Cited by 1 publication

References 151 publications

Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights

Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights

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