Neuropsychological profile of schizophrenia with and without obsessive compulsive disorder

Kazhungil, Firoz; Kumar, Keshav; Viswanath, Biju; Shankar, Ravi; Thennarasu, Kandavel; Math, Suresh Bada; Venkatasubramanian, Ganesan; Reddy, Y.C. Janardhan

doi:10.1016/j.ajp.2017.04.004

Cited by 19 publications

(17 citation statements)

References 59 publications

(57 reference statements)

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“…There was no difference in terms of age at onset and duration of illness consistent with studies by Rajkumar et al, 2008, 8 and Kazhungil et al, 2017. 12 The findings are not in line with the majority previous studies where schizophrenia with OCD/OCS patients have earlier age at onset and younger age at assessment. 4,13,14,11,15 In our study, duration of untreated illness was more in schizophrenia with OCD/OCS.…”

Section: Impact Of Ocd On Schizophreniacontrasting

confidence: 84%

“…4 In a recent Indian study by Kazhungil et al, 2017, the mean total score, positive symptom score and general psychopathology score on PANSS was significantly lower in schizophrenia patients with OCD. 12 From a neurobiological point of view, negative symptoms of schizophrenia are associated with different cortical regions than those shown to be involved in OCD (Cavallaro et al, 2003) suggesting that two may share an inverse relationship. Schizophrenia and OCD share similar cortical subcortical pathways; in particular a frontal-striatal-thalamic-cortical circuit has been implicated in both illness with specific patterns of prefrontal impairment.…”

Section: Impact Of Ocd On Schizophreniamentioning

confidence: 99%

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Sociodemographic Profile of Schizophrenia With and Without Obsessive Compulsive Symptoms

Adavalath¹,

Shoukkathaly²,

Balachandran³

2017

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BACKGROUND Schizophrenia is a complex neurobehavioural disorder affecting about 1% of the general population. Schizophrenia is characterised by disordered cognition including a "gain of function" in psychotic symptoms and "loss of function" in specific cognitive functions such as working and declarative memory, but without the progressive dementia that characterises classical neurodegenerative disorder. The primary aim of the study was to compare the profile of patients diagnosed with schizophrenia with and without obsessive compulsive symptoms. MATERIALS AND METHODS This was a cross-sectional study. Consecutive patients in the age group of 18-59 years diagnosed to have schizophrenia with at least 2 years of duration of illness consulting in outpatient department of psychiatry and inpatients admitted in psychiatry ward at a tertiary care centre at northern Kerala were included. Clinical status of the patient was assessed using Structured Clinical Interview for DSM-IV-TR (SCID I), the Positive and Negative Symptom Scale (PANSS) and Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) severity and symptom checklist. YBOCS ≥16 was labelled as OCD. Sociodemographic profile of the patients will be collected using specially designed pro forma. Data analysis was done using software "R" (Chi-square and t test). RESULTS A total of 73 participants formed the study sample. The schizophrenia with OCS were better educated were more likely to come from a semi-urban background had alcohol dependence and longer duration of untreated illness than the group with schizophrenia alone. Though, there was increased frequency of paranoid subtype in the study sample, schizophrenia patients with OCD/OCS had majority of undifferentiated subtype. There is no difference in gender, family type, marital status, occupation, religion or socioeconomic status. CONCLUSION Schizophrenia patients with OCS/OCD and without OCS/OCD have comparable clinical profile with few exceptions. There is a scope for analysis of sociodemographic data of schizophrenia with OCS/OCD. Finally, the evidence to consider schizo-obsessive as a distinct diagnostic entity is inconclusive and warrants further studies.

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Section: Impact Of Ocd On Schizophreniacontrasting

confidence: 84%

Section: Impact Of Ocd On Schizophreniamentioning

confidence: 99%

Sociodemographic Profile of Schizophrenia With and Without Obsessive Compulsive Symptoms

Adavalath¹,

Shoukkathaly²,

Balachandran³

2017

jebmh

View full text Add to dashboard Cite

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“…[41] We examined the neuropsychological profile of schizophrenia with and without OCD with a comprehensive battery of tests of attention, executive functions, and memory but found no differences between the two groups. [42] It appears that there are no consistent neuropsychological impairments typical of schizo-obsessive disorder; however, larger studies with uniform methodology may be needed to further our understanding of this area.…”

Section: Obsessive–compulsive Disorder In the Context Of Schizophreniamentioning

confidence: 99%

Obsessive–compulsive disorder comorbid with schizophrenia and bipolar disorder

Sharma

Reddy

2019

Indian J Psychiatry

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Obsessive Compulsive Disorder (OCD) and Obsessive Compulsive Symptoms (OCS) are known to be highly comorbid with bipolar disorder and schizophrenia. Comorbid OCD/OCS influences the course of schizophrenia and bipolar disorder. There is also some evidence to suggest that a diagnosis of OCD may be associated with elevated risk for later development of psychosis and bipolar disorder. Comorbid OCD/OCS is associated with a greater severity of schizophrenia phenotype and poorer prognosis. In addition, certain atypical antipsychotics, clozapine in particular are known to induce or worsen OCS in schizophrenia. OCD when comorbid with bipolar disorder mostly runs an episodic course with worsening and improvement of OCD/OCS in depressive and in manic/hypomanic phases respectively. There is limited systematic data on the treatment of OCD in schizophrenia and bipolar disorder. When OCD presents in the context of schizophrenia, management may include treatment with atypical antipsychotics with limited serotonergic properties, changing the antipsychotic, reduction in the dose of the antipsychotic, addition of cognitive-behavior therapy (CBT), or a specific serotonin reuptake inhibitor (SSRI). When OCD is comorbid with bipolar disorder, mood stabilization is the priority. CBT may be preferred over SSRIs to treat OCD/OCS that persist in between the mood episodes because SSRIs may induce a switch or worsen the course of bipolar disorder. SSRIs when indicated have to be used judiciously under the cover of adequate mood stabilization.

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“…Kazhungil et al . [112] compared the neuropsychological profile of OCD and schizophrenia and reported no significant differences between the two groups and also failed to establish a unique neuropsychological profile for schizo-obsessive disorder. Considering the shared risk factors, both genetic and environmental, and shared neurobiology across psychiatric disorders, this considerable overlap in neuropsychological deficits is expected.…”

Section: Relation Between Clinical Features Subgroups and Neuropsycmentioning

confidence: 99%

Neurocognitive deficits in obsessive–compulsive disorder: A selective review

Suhas

Rao

2019

Indian J Psychiatry

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Obsessive–compulsive disorder (OCD) is a debilitating mental illness characterized by an early onset and chronic course. Evidence from several lines of research suggests significant neuropsychological deficits in patients with OCD; executive dysfunction and nonverbal memory deficits have been reported consistently in OCD. These deficits persist despite controlling potential confounders such as comorbidity, severity of illness, and medications. Neuropsychological impairments are independent of illness severity, thus suggesting that the neuropsychological deficits are trait markers of the disease. In addition, these deficits are seen in first-degree relatives of individuals with OCD. These reports suggest that neuropsychological deficits are potential endophenotype markers in OCD. Neuropsychological studies in pediatric OCD are limited; they show impairments of small effect size across multiple domains but with doubtful clinical significance. Preliminary evidence shows that different symptom dimensions of OCD may have unique neuropsychological deficits suggestive of discrete but overlapping neuroanatomical regions for individual symptom dimensions. Overall, neuropsychological deficits further support the role of frontostriatal circuits in the neurobiology of OCD. In addition, emerging literature also suggests the important role of other areas, in particular parietal cortex. Preliminary evidence suggests the possible role of neuropsychological deficits to be markers of treatment response but needs to be examined in future. Longitudinal studies with examination of patients at different time points and examination of their potential utility as predictors of treatment response are needed in future.

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Neuropsychological profile of schizophrenia with and without obsessive compulsive disorder

Cited by 19 publications

References 59 publications

Sociodemographic Profile of Schizophrenia With and Without Obsessive Compulsive Symptoms

Sociodemographic Profile of Schizophrenia With and Without Obsessive Compulsive Symptoms

Obsessive–compulsive disorder comorbid with schizophrenia and bipolar disorder

Neurocognitive deficits in obsessive–compulsive disorder: A selective review

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