Neuropsychological profile in patients with obsessive-compulsive disorder over a period of 4-month treatment

Kim, Myung Sun; Park, Soo‐Jin; Shin, Min Sup; Kwon, Jun Soo

doi:10.1016/s0022-3956(02)00017-1

Cited by 94 publications

(81 citation statements)

References 44 publications

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“…Notwithstanding, we must underline that all the patients included in the current study had been diagnosed with tic disorder as the primary problem. Recent investigations using the ROCF with adult OCD patients found comparable group discrepancies to ours in immediate and delayed recall, with relatively normal performances on the copy score (Kim, Park, Shin, & Kwon, 2002;Kim et al, 2003;Roh et al, 2005). However, the specificity of this nonverbal memory deficit has not previously been clearly established when comparing OCD with other psychiatric population (Moritz et al, 2005).…”

Section: Discussionsupporting

confidence: 77%

Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder

Lavoie

Thibault

Stip

et al. 2007

Cognitive Neuropsychiatry

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Introduction-The main aim of the current study was to assess whether adults with either Tourette syndrome (TS) or chronic tic disorder (CTD) show a similar neuropsychological profile. Neuropsychological investigations of tic disorders have been mostly focused on children, mainly because symptoms peak during that period. Little has been carried out on adults, even if a significant proportion of the tic population experience moderate or marked levels of tic frequency throughout adulthood. Still, it is not clear whether neuropsychological performances are affected to the same degree in adults with TS and CTD.

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Section: Discussionsupporting

confidence: 77%

Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder

Lavoie

Thibault

Stip

et al. 2007

Cognitive Neuropsychiatry

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“…Cross-sectional studies have shown that OCD patients present difficulties in VSM when compared with healthy controls (Kuelz et al, 2004;Purcell et al, 1998;Rao et al, 2008;Savage et al, 1999), and longitudinal studies indicate the presence of visuospatial deficits even before the onset of symptoms (Bloch et al, 2011;Grisham et al, 2009). Moreover, the improvement of VSM has been described after successful treatment for OCD (Kim et al, 2002). Kuelz et al (2008) found that major responders to treatment improved significantly more than minor responders on the ROCF immediate and delayed recall.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, in our sample, GVC not only showed efficacy in reducing OCS in treatment refractory OCD patients, but was also safe from a neuropsychological perspective. Several studies have identified VSM as a specific and central neuropsychological deficit in OCD (Bloch et al, 2011;Grisham et al, 2009;Kuelz et al, 2004Kuelz et al, , 2006Kim et al, 2002;Penadés et al, 2005;Purcell et al, 1998;Rao et al, 2008;Segalàs et al, 2008;Shin et al, 2013). Cross-sectional studies have shown that OCD patients present difficulties in VSM when compared with healthy controls (Kuelz et al, 2004;Purcell et al, 1998;Rao et al, 2008;Savage et al, 1999), and longitudinal studies indicate the presence of visuospatial deficits even before the onset of symptoms (Bloch et al, 2011;Grisham et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients

Batistuzzo

Hoexter

Taub

et al. 2015

Neuropsychopharmacol

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Gamma ventral capsulotomy (GVC) radiosurgery is intended to minimize side effects while maintaining the efficacy of traditional thermocoagulation techniques for the treatment of refractory obsessive-compulsive disorder (OCD). Neuropsychological outcomes are not clear based on previous studies and, therefore, we investigated the effects of GVC on cognitive and motor performance. A doubleblind, randomized controlled trial (RCT) was conducted with 16 refractory OCD patients allocated to active treatment (n = 8) and sham (n = 8) groups. A comprehensive neuropsychological evaluation including intellectual functioning, attention, verbal and visuospatial learning and memory, visuospatial perception, inhibitory control, cognitive flexibility, and motor functioning was applied at baseline and one year after the procedure. Secondary analysis included all operated patients: eight from the active group, four from the sham group who were submitted to surgery after blind was broken, and five patients from a previous open pilot study (n = 5), totaling 17 patients. In the RCT, visuospatial memory (VSM) performance significantly improved in the active group after GVC (p = 0.008), and remained stable in the sham group. Considering all patients operated, there was no decline in cognitive or motor functioning after one year of follow-up. Our initial results after 1 year of follow-up suggests that GVC not only is a safe procedure in terms of neuropsychological functioning but in fact may actually improve certain neuropsychological domains, particularly VSM performance, in treatment refractory OCD patients.

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“…For example, some studies have detected impairments of nonverbal memory in patients with OCD, which have been attributed to failures in the employment of appropriate organizational strategies [Kim et al, 2002;Savage et al, 1999;Shin et al, 2004], whereas other studies have reported detecting set-shifting deficits [Aycicegi et al, 2003;Hymas et al, 1991;Veale et al, 1996], and decisionmaking [Cavedini et al, 2002] and response inhibition [Aycicegi et al, 2003;Bannon et al, 2002], all of which are known to be dependent on the frontal cortex [Chamberlain et al, 2005].…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological correlates of behavioral response inhibition in patients with obsessive–compulsive disorder

Kim

Yoo

et al. 2006

Depress. Anxiety

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In this study, we have attempted to determine the electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder (OCD). To evaluate response inhibition ability, we have used the Go/NoGo task and measured N2 and P3 event-related potential (ERP) components. Both the OCD and control groups exhibited greater and more frontally distributed N2 and P3 amplitudes in the NoGo condition compared to what we observed in the Go condition. However, the patients with OCD also manifested reduced NoGo-N2 and Go-N2 amplitudes at the frontocentral electrode sites compared to the controls. In addition, the NoGo-N2 amplitudes were more posteriorly distributed in patients with OCD than in controls. The NoGo-N2 amplitudes and latencies measured at the central sites were also negatively correlated with the obsession score on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The OCD and control groups were comparable with regard to Go-P3 and NoGo-P3 amplitude and latencies. Our findings suggest dysfunctions in frontal regions mediating response inhibition in OCD, consistent with the involvement of response inhibition in the pathophysiology of this disorder. In addition, NoGo-N2 seems to result in more accurate response inhibition measurements in patients with OCD than does NoGo-P3. Depression and Anxiety 24:22-31, 2007.

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Neuropsychological profile in patients with obsessive-compulsive disorder over a period of 4-month treatment

Cited by 94 publications

References 44 publications

Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder

Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder

Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive–Compulsive Disorder Patients

Electrophysiological correlates of behavioral response inhibition in patients with obsessive–compulsive disorder

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