Neuropsychological Outcome of Children With Intrauterine Growth Restriction: A 9-Year Prospective Study

Geva, Ronny; Eshel, Rina; Leitner, Yael; Valevski, Aviva Fattal; Harel, Shaul

doi:10.1542/peds.2005-2343

Cited by 225 publications

(180 citation statements)

References 48 publications

(65 reference statements)

Supporting

Mentioning

163

Contrasting

Unclassified

Order By: Relevance

“…Within the SGA case group, we could not demonstrate an association between IQ and small HC, either at birth or at follow up. This was in contrast to the findings reported by Geva et al, who stud ied neuropsychological outcomes of mainly full term growth restricted children (7). However, small head size at follow up appeared to have some association with behavioral problems and impaired motor skills.…”

Section: Discussioncontrasting

confidence: 99%

“…These findings confirm the data from other follow up studies of very preterm SGA children (5)(6)(7)9). Apparently, attention is a vulnerable neuropsychological domain in very preterm SGA children.…”

Section: Discussionsupporting

confidence: 90%

“…Cognitive skills have very rarely been assessed in children born very preterm and SGA; most studies reporting in the domains of cognitive skills studied SGA children born up to 37 wk GA or those born full term. The studies reported poorer performances by these children with respect to these neuropsychological domains (7,8,14,20). In our study, the rates of abnormal and borderline scores in nearly all domains exceeded those one would expect in a normal population.…”

Section: Discussioncontrasting

confidence: 62%

“…Attention is also very often affected in SGA children born moderately preterm or at full term (5,7). Earlier, lower scores on visual perception were found in full term and moderately preterm SGA children (7).…”

Section: Discussionmentioning

confidence: 87%

“…This holds good for SGA children born at term and also for those born preterm (<37 wk) (5). Lower intelligence quotients (IQs) are reported in full term and moderately preterm SGA children in particu lar (7,8). It would be interesting to ascertain whether similar domains are affected in very preterm SGA children, given that the pathophysiologic mechanisms relating to brain development may be different in these infants.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Functional outcome of very preterm–born and small-for-gestational-age children at school age

et al. 2012

View full text Add to dashboard Cite

Background: Our aim was to determine functional outcome of very preterm-born and small-for-gestational-age (sGa) children as compared with matched controls at school age. Methods: We included 28 very preterm sGa children (Ga <32 wk, birth weight (BW) <10th percentile), born in 2000-2001. We also included 28 very preterm but appropriate-forgestational-age (aGa) children, matched for Ga, gender, and birth year, as controls. We assessed motor skills, intelligence quotient (IQ), attention, verbal memory, visual perception, visuomotor integration, executive functioning, and behavior of both sets of children at school age. results: The sGa children had a median Ga of 29.7 wk and BW of 888 g, whereas the controls had a median Ga of 29.4 wk and BW of 1,163 g. at 8.6 y, the median total IQ of the sGa children was 94 as compared with 95 in the controls (not significant). Performance IQ was significantly lower in sGa children (89 vs. 95, P = 0.043), whereas verbal IQ was not (95 vs. 95). Total motor skills (P = 0.048) and fine motor skills (P = 0.021) were worse in sGa children. Furthermore, sGa children scored lower on selective attention (P = 0.026) and visual perception (P = 0.025). Other scores did not differ significantly between groups. conclusion: The differences we found between the groups were small. This suggests that the impaired functioning of very preterm-born sGa children is attributable to their having been born very preterm rather than to being sGa.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 87%

mentioning

confidence: 99%

See 3 more Smart Citations

Functional outcome of very preterm–born and small-for-gestational-age children at school age

et al. 2012

View full text Add to dashboard Cite

show abstract

Association of Fetal Growth Restriction With Neurocognitive Function After Repeated Antenatal Betamethasone Treatment vs Placebo

et al. 2019

View full text Add to dashboard Cite

show abstract

Association of Intrauterine Growth Restriction and Small for Gestational Age Status With Childhood Cognitive Outcomes

et al. 2020

View full text Add to dashboard Cite

The magnitude of the association of intrauterine growth restriction (IUGR) and small for gestational age (SGA) status with cognitive outcomes in preterm and term-born children has not been established.OBJECTIVE To examine cognitive outcomes of preterm and term-born children who had IUGR and were SGA compared with children who were appropriate for gestational age (AGA) during the first 12 years of life.DATA SOURCES For this systematic review and meta-analysis, the Scopus, PubMed, Web of Science, Science Direct, PsycInfo, and ERIC databases were searched for English-language, peer-reviewed literature published between January 1, 2000, and February 20, 2020. The following Medical Subject Heading terms for IUGR and SGA and cognitive outcomes were used: intrauterine growth restriction, intrauterine growth retardation, small for gestational age AND neurodevelopment, neurodevelopmental outcome, developmental outcomes, and cognitive development.STUDY SELECTION Inclusion criteria were assessment of cognitive outcomes (full-scale IQ or a cognitive subscale), inclusion of an AGA group as comparison group, and inclusion of gestational age at birth and completion of cognitive assessment up to 12 years of age. DATA EXTRACTION AND SYNTHESISThe Meta-analysis of Observational Studies in Epidemiology (MOOSE) reporting guidelines were followed. Data were double screened for full-text articles, and a subset were independently coded by 2 authors. Standardized mean differences (SMDs) and odd ratios from individual studies were pooled by applying random-effects models. MAIN OUTCOMES AND MEASURESCognitive outcomes, defined as mental, cognitive, or IQ scores, estimated with standardized practitioner-based cognitive tests or as borderline intellectual impairment (BII), defined as mental, cognitive, or IQ scores at least 1 SD below the mean cognitive score. RESULTSIn this study of 89 samples from 60 studies including 52 822 children, children who had IUGR and were SGA had significantly poorer cognitive outcomes (eg, cognitive scores and BII) than children with AGA in childhood. For cognitive scores, associations are consistent for preterm (SMD, −0.27; 95% CI, −0.38 to −0.17) and term-born children (SMD, −0.39; 95% CI, −0.50 to −0.28), with higher effect sizes reported for term-born IUGR and AGA group comparisons (SMD, -0.58; 95% CI, -0.82 to -0.35). Analyses on BII revealed a significantly increased risk in the preterm children who had IUGR and were SGA (odds ratio, 1.57; 95% CI, 1.40-1.77) compared with the children with AGA.CONCLUSIONS AND RELEVANCE Growth vulnerabilities assessed antenatally (IUGR) and at the time of birth (SGA) are significantly associated with lower childhood cognitive outcomes in preterm and term-born children compared with children with AGA. These findings highlight the need to develop interventions that boost cognitive functions in these high-risk groups.

show abstract

Neuropsychological Outcome of Children With Intrauterine Growth Restriction: A 9-Year Prospective Study

Cited by 225 publications

References 48 publications

Functional outcome of very preterm–born and small-for-gestational-age children at school age

Functional outcome of very preterm–born and small-for-gestational-age children at school age

Association of Fetal Growth Restriction With Neurocognitive Function After Repeated Antenatal Betamethasone Treatment vs Placebo

Association of Intrauterine Growth Restriction and Small for Gestational Age Status With Childhood Cognitive Outcomes

Contact Info

Product

Resources

About