Neuropsychological investigations and event-related potentials in obstructive sleep apnea syndrome before and during CPAP-therapy

Kotterba, Sylvia; Rasche, Kurt; Widdig, W.; Duscha, Christina; Blombach, Svenja; Schultze‐Werninghaus, G.; Malin, J.‐P.

doi:10.1016/s0022-510x(98)00131-2

Cited by 122 publications

(101 citation statements)

References 19 publications

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“…[23][24][25][26] CPAP has shown mixed success in rectifying these impairments, 23,[26][27][28][29] although lingering posttreatment impairments are not uncommon. 23,30,31 In contrast, several large-scale studies in recent years have found cognitive impairment to be mild or nonsignificant in patients with OSA compared to control patients.…”

Section: ) (B)mentioning

confidence: 99%

Overnight Motor Skill Learning Outcomes in Obstructive Sleep Apnea: Effect of Continuous Positive Airway Pressure

Landry

O'Driscoll

Hamilton

et al. 2016

Journal of Clinical Sleep Medicine

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Study Objective: To determine the effectiveness of continuous positive airway pressure (CPAP) therapy in alleviating known impairments in the overnight consolidation of motor skill learning in patients with obstructive sleep apnea (OSA). Methods: Twenty-five patients with untreated moderate-severe OSA, 13 first-night CPAP users, 17 compliant CPAP users, and 14 healthy control patients were trained on a motor sequence learning task (Sequential Finger Tapping Task, SFTT) and were subsequently tested prior to and after polysomnographic recorded sleep. Measures of subjective sleepiness (Karolinska Sleepiness Scale) and sustained attention (Psychomotor Vigilance Task) were also completed before and after sleep. Results: Typical analyses of overnight improvement on the SFTT show significantly greater overnight gains in motor task speed in controls (+11.6 ± 4.7%, p = 0.007) and compliant CPAP users (+8.9 ± 4.3%, p = 0.008) compared to patients with OSA (−4.86 ± 4.5%). Additional analyses suggest that these improvements in motor performance occurred prior to the sleep episode, as all groups significantly improved (15% to 22%) over a 10-min presleep rest period. Thereafter, performance in all groups significantly deteriorated over sleep (6% to 16%) with trends toward patients with OSA showing greater losses in performance compared to control patients and compliant CPAP users. No between-group differences in subjective sleepiness and sustained attention were found presleep and postsleep. Conclusions: The current data suggest impairments in overnight motor learning in patients with OSA may be a combination of deficient stabilization of memory over a sleep episode as well as increased vulnerability to time on task fatigue effects. Compliant CPAP usage possibly offsets both of these impediments to learning outcomes by improving both sleep quality and subsequent daytime function. Keywords: cognitive impairment, consolidation, CPAP, learning, memory, motor skills, obstructive sleep apnea, OSA, sleep dependent Citation: Landry S, O'Driscoll DM, Hamilton GS, Conduit R. Overnight motor skill learning outcomes in obstructive sleep apnea: effect of continuous positive airway pressure.

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Section: ) (B)mentioning

confidence: 99%

Overnight Motor Skill Learning Outcomes in Obstructive Sleep Apnea: Effect of Continuous Positive Airway Pressure

Landry

O'Driscoll

Hamilton

et al. 2016

Journal of Clinical Sleep Medicine

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“…The remaining driving simulator studies did not compare results in CPAP-treated patients with non-apneic control subjects, and thus do not address if CPAP treatment normalizes driving disturbance in OSA patients. Several recent studies suggest that CPAP treatment may be only partially effective in restoring cognitive function, [29][30][31][32][33] cortical activation, 31,34 and daytime somnolence 35,36 even for subjects who comply optimally with therapy. 36 The purpose of the present study was therefore to measure the effects of ~3 months of CPAP treatment on driving simulator performance in patients with severe, previously untreated OSA.…”

Section: Subject Assessmentmentioning

confidence: 99%

“…However, in discussing the results of active versus sham CPAP treatment in OSA patients, Hack et al 18 noted that driving performance in the actively treated group (mean CPAP use 5.6 h/night) did not quite fall to figures obtained previously in the same laboratory in a matched control group using the same simulator. 4 Also, several other studies have shown only partial recovery of daytime sleepiness and no significant improvements in neurophysiological function following treatment of OSA, [29][30][31][33][34][35][36]44 potentially contributing to persistent driving impairment. One study 36 demonstrated that approximately 60% of OSA subjects had persistent daytime sleepiness (multiple sleep latency test sleep onset time < 7.5 min) despite 3 months of optimal (> 6 h/ night) CPAP treatment.…”

Section: Data Analysis and Statisticsmentioning

confidence: 99%

Driving Simulator Performance Remains Impaired In Patients With Severe OSA after CPAP Treatment

Vakulin

Baulk²,

Catcheside

et al. 2011

Journal of Clinical Sleep Medicine

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“…Age predisposes to SDB (Fleury 1992). SDB is recognized as an important risk factor for neurovascular disease (Diomedi et al 1998;Mayer et al 1999;Kotterba et al 1998).…”

Section: P Rimarymentioning

confidence: 99%

High prevalence of sleep‐disordered breathing in patients with primary open‐angle glaucoma

Onen

Mouriaux

Berramdane

et al. 2000

Acta Ophthalmologica Scandinavica

106

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ABSTRACT.Purpose: Elevated intraocular pressure and systemic hemodynamic changes are main risk factors in primary open-angle glaucoma (POAG). Sleep-disordered breathing (SDB) characterized by snoring, excessive daytime sleepiness and insomnia is accompanied by large swings in blood pressure and repetitive hypoxic periods during sleep. The aim of this study was to evaluate whether there is any relationship between SDB and POAG. Methods: Consecutively, 212 outpatients with POAG and 218 outpatients without POAG were recruited. Both eyes were examined. An interviewer-administered semi-structured questionnaire was used to collect SDB-related symptoms. Results: After controlling for age, relative to control group, POAG patients showed a high prevalence of snoring (47.6%, pΩ0.04), snoring plus, excessive daytime sleepiness (27.3%, pΩ0.01) and snoring plus, excessive daytime sleepiness, plus insomnia (14.6%, pΩ0.01). Conclusion: We found a high prevalence of SDB in patients with POAG. Chronic hemodynamic changes and recurrent severe hypoxia resulting from SDB may contribute to anoxic optic nerve damage, implicated in glaucoma.

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Neuropsychological investigations and event-related potentials in obstructive sleep apnea syndrome before and during CPAP-therapy

Cited by 122 publications

References 19 publications

Overnight Motor Skill Learning Outcomes in Obstructive Sleep Apnea: Effect of Continuous Positive Airway Pressure

Overnight Motor Skill Learning Outcomes in Obstructive Sleep Apnea: Effect of Continuous Positive Airway Pressure

Driving Simulator Performance Remains Impaired In Patients With Severe OSA after CPAP Treatment

High prevalence of sleep‐disordered breathing in patients with primary open‐angle glaucoma

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