Neuropsychological impairments in panic disorder: A systematic review

O'Sullivan, K; Newman, Emily

doi:10.1016/j.jad.2014.06.024

Cited by 26 publications

(20 citation statements)

References 65 publications

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“…Higher levels of IL-1β and IL-6 in panic disorder patients may interfere with differentiation and activation of naïve CD8+ T, possibly reducing inflammation. Links between inflammatory response and presentation of neurodegeneration and neuropsychological performance [ 41 , 42 ] are consistent both with our results and the limited evidence for neuropsychological impairments in PD patients [ 43 ]. Although cause and consequence remain unclear, additional research into immune modulation for PD cases could have value for patients and provide options to treating physicians.…”

Section: Discussionsupporting

confidence: 91%

Altered immune phenotype and DNA methylation in panic disorder

et al. 2020

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Background Multiple studies have related psychiatric disorders and immune alterations. Panic disorder (PD) has been linked with changes in leukocytes distributions in several small studies using different methods for immune characterization. Additionally, alterations in the methylation of repetitive DNA elements, such as LINE-1, have been associated with mental disorders. Here, we use peripheral blood DNA methylation data from two studies and an updated DNA methylation deconvolution library to investigate the relation of leukocyte proportions and methylation status of repetitive elements in 133 patients with panic disorder compared with 118 controls. Methods and results We used DNA methylation data to deconvolute leukocyte cell-type proportions and to infer LINE-1 element methylation comparing PD cases and controls. We also identified differentially methylated CpGs associated with PD using an epigenome-wide association study approach (EWAS), with models adjusting for sex, age, and cell-type proportions. Individuals with PD had a lower proportion of CD8T cells (OR: 0.86, 95% CI: 0.78–0.96, P-adj = 0.030) when adjusting for age, sex, and study compared with controls. Also, PD cases had significantly lower LINE-1 repetitive element methylation than controls (P < 0.001). The EWAS identified 61 differentially methylated CpGs (58 hypo- and 3 hypermethylated) in PD (Bonferroni adjusted P < 1.33 × 10–7). Conclusions These results suggest that those with panic disorder have changes to their immune system and dysregulation of repeat elements relative to controls.

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Section: Discussionsupporting

confidence: 91%

Altered immune phenotype and DNA methylation in panic disorder

et al. 2020

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“…In a review of the literature investigating the neuropsychological disturbances PDA, limited support for impairment in short-term memory among individuals with PD was found in some but not all studies. Moreover, the studies did find some evidence for impairment in other areas of cognitive functioning, including executive function, long-term memory, visuospatial or perceptual abilities and working memory (O’Sullivan & Newman 2014). The review included 14 studies (total 439 patients, 510 healthy controls), the majority of which had average to high methodological quality.…”

Section: Neurocognitionmentioning

confidence: 99%

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

Bandelow

Baldwin

Abelli

et al. 2016

The World Journal of Biological Psychiatry

254

165

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“…A recent systematic review did not support the presence of cognitive functioning deficits in PD though there was marginal evidence of short-term memory deficits among PD individuals[86]; these findings reflected those of Gladsjo et al[87] who found no group differences between PD subjects and healthy controls on visuospatial, learning, memory, psychomotor speed, and attention tasks.…”

Section: Anxiety Disordersmentioning

confidence: 86%

Cognitive Remediation and Bias Modification Strategies in Mood and Anxiety Disorders

Gold

Montana

Sylvia

et al. 2016

Curr Behav Neurosci Rep

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Purpose of review Cognitive impairments and biases, which are prevalent in patients with mood and anxiety disorders, can affect quality of life and functioning. Traditional treatments are only insufficiently addressing these impairments and biases. We review the cognitive impairments and biases present in these disorders as well as treatments targeting these domains. Recent findings Interventions aimed at improving cognitive impairments and biases may help improve cognitive deficits and overall functioning in patients with mood and anxiety disorders. Direct comparisons of treatments for cognitive impairments or biases versus more traditional psychosocial interventions have produced diverse results. Summary Overall, treatments for cognitive impairments and cognitive biases warrant additional study in clinical trials. Future research should explore cognitive remediation and cognitive bias modification adjunctive to psychosocial treatments to optimize patient outcomes in mood and anxiety disorders.

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Neuropsychological impairments in panic disorder: A systematic review

Cited by 26 publications

References 65 publications

Altered immune phenotype and DNA methylation in panic disorder

Altered immune phenotype and DNA methylation in panic disorder

Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

Cognitive Remediation and Bias Modification Strategies in Mood and Anxiety Disorders

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