Neuropsychological Functioning in Youth with Bipolar Disorder

Doyle, Alysa E.; Wilens, Timothy E.; Kwon, Anne; Seidman, Larry J.; Faraone, Stephen V.; Fried, Roland; Swezey, Allison; Snyder, Lindsey E.; Biederman, Joseph

doi:10.1016/j.biopsych.2005.07.019

Cited by 134 publications

(129 citation statements)

References 56 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…31 Our data suggests that BD + ADHD patients show a decrement in interference control after correcting for baseline processing speed. This refinement was also conducted by Doyle et al, 12 and differences between BD and control subjects (after statistic control for ADHD) emerged but were not significant, possibly due to the presence of higher rates of other comorbidities in their sample. In our sample, all comorbidities were statistically controlled according to our restrictive definition of confounding variables.…”

Section: Discussionmentioning

confidence: 85%

“…A study conducted by Doyle et al 12 compared children and adolescents with BD (n=57); 74% of these participants also had comorbid ADHD, and controls (n=46). They found that JBD was associated with impairments on tasks reflecting sustaining attention, working memory, and processing speed (using the Stroop word and color cards) even after controlling for ADHD.…”

Section: Discussionmentioning

confidence: 99%

“…16 We further analyzed the Stroop Interference score through the correction for baseline processing speed, thus constituting a more pure measure of interference control. 12 A recent review reported that impairments in interference control are specific to BD. 31 Our data suggests that BD + ADHD patients show a decrement in interference control after correcting for baseline processing speed.…”

Section: Discussionmentioning

confidence: 99%

“…Such results are in accordance with the clinical characteristics associated with JBD, such as behavioral lack of control, impulsivity, and aggressiveness. 12 Abnormal brain structures and circuits have been suggested as additive substrates of the observed synergistic dysfunctional neurocognitive performance present in the comorbidity between JBD and ADHD. Left dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) have been associated with interference control assessed by the Stroop paradigm.…”

Section: Discussionmentioning

confidence: 99%

“…Comparisons have been performed between children and adolescents with BD and healthy controls in several neurocognitive domains, including executive functions, sustained attention, response flexibility, inhibition, working memory, and verbal learning. [9][10][11][12] Comorbidity with ADHD had little or no significant effect on neurocognitive performance. Conversely, other studies, such as the one conducted by Pavuluri et al, 13 found that patients with pediatric BD and ADHD had a worse performance in attentional and executive function (EF) domains than BD-only patients, despite illness state (manic or euthymic) or medication status.…”

Section: Introductionmentioning

confidence: 98%

See 4 more Smart Citations

Does comorbid bipolar disorder increase neuropsychological impairment in children and adolescents with ADHD?

Narvaez

Zeni

Coelho

et al. 2014

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: To assess differences in executive functioning between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) comorbid or not with bipolar disorder (BD), and to study the neuropsychological profile of subjects with the comorbidity in a clinical sample from a developing country. Method: Case-control study comparing 23 participants with BD + ADHD and 85 ADHD-only subjects aged 6 to 17 years old. Both groups were drug-free. Executive function domains were assessed with the Stroop Test, the Wisconsin Card Sorting Test, and the Continuous Performance Test II. Results: The group with juvenile BD + ADHD showed a significantly worse performance on the Stroop task, including time in color (p = 0.002), time in color-word (p , 0.001), interference, number or errors in color and color-word (p = 0.001), and number of errors in word cards (p = 0.028). No between-group differences were found in other tests. Conclusions: Our findings suggest that ADHD-only and ADHD + BD do not show differences in inhibitory control and set-shifting domains. However, children and adolescents with BD and comorbid ADHD show greater impairment in processing speed and interference control. This suggests a potentially higher impairment in the dorsolateral prefrontal cortex and may be a potential neuropsychological signature of juvenile BD comorbid with ADHD.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%