Neuropsychological Functioning in Preterm-Born Twins and Singletons at Preschool Age

Raz, Sarah; Piercy, Jamie; Heitzer, Andrew M.; Peters, Brittany N.; Newman, Julie Bapp; DeBastos, Angela K.; Ofen, Noa; Batton, Beau; Batton, Daniel G.

doi:10.1017/s1355617716000758

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…We examined the remaining eight studies and four of them were prospective follow-up studies (Bodeau-Livinec et al, 2013; de Zeeuw et al, 2012; Eras et al, 2013; Gnanendran et al, 2015), three were cross-sectional studies (Hjern et al, 2012; Hur & Lynn, 2013; Raz et al, 2016), while one was a randomized controlled trial (Manuck et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

“…This study showed that Swedish male and female twins had slightly higher mean grade points in primary school compared with singletons, while male twins had slightly lower scores on IQ tests at military conscription at 18–19 years of age. The studies by Eras et al (2013) and Raz et al (2016) were ranked 5th and 6th, respectively. Eras et al conducted a prospective study of pre-term infants (≤32 weeks gestational age) and examined them for moderate or severe cerebral palsy, and severe bilateral hearing loss or bilateral blindness at 12 to 18 months of age They also used the MDI and PDI scores to determine neurodevelopment, but did not find significant differences between singletons and twins in MDI or PDI.…”

Section: Resultsmentioning

confidence: 99%

“…The top six studies utilized at least two different instruments to assess neurodevelopmental outcomes (Bodeau-Livinec et al, 2013; Eras et al, 2013; Gnanendran et al, 2015; Hjern et al, 2012; Manuck et al, 2014; Raz et al, 2016). Manuck et al (2014) utilized the Bayley Scale of Infant Development (BSID) and Mental Development Index (MDI), and cerebral palsy was assessed by a pediatric neurologist (Manuck et al, 2014).…”

Section: Methodsmentioning

confidence: 99%

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Neurodevelopmental Outcomes of Twins Compared With Singleton Children: A Systematic Review

et al. 2018

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More than 200 million children aged <5 years fail to reach their full cognitive potential, and children born as twins are particularly at risk. In this article, we review studies that examined differences in the neurodevelopmental outcomes of twins compared to singletons. We searched the Medline database for articles on twins, singletons, neuro, and cognitive development. We also inspected bibliographies of relevant publications to identify related articles from 2011 to 2017. Our search criteria yielded 162 studies, 8 of which met the inclusion criteria. Of the eight studies examined, four were prospective follow-up studies, three were cross-sectional studies, and one was a randomized controlled trial. Five of these studies were carried out in developed countries, and they found no statistically significant difference in neurodevelopmental outcomes among twins and singletons. However, two of the three studies carried out in developing countries found a difference with singletons having significantly higher academic ratings than twins. Studies in which neurodevelopmental outcomes were measured early in life (1-5 years) showed no significant twin-singleton differences, while those in which it was measured later in life showed mixed twin-singleton differences. Overall, these studies may have been underpowered and may not have been optimally designed and implemented. There is need for studies with adequate sample sizes, good design, and optimal measurement of all relevant covariates in order to resolve the conflicting reports in the literature.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Neurodevelopmental Outcomes of Twins Compared With Singleton Children: A Systematic Review

et al. 2018

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“…Thus, for example, lower oxygen saturation in cerebral tissue is related to worse cognitive outcomes in preterm children [41]. Regarding multiple or single pregnancy, preterm twins seem to show lower language and visual processing outcomes than preterm single births [42]. Based on our results and scientific evidence, it appears that the factors related to greater neuropsychological dysfunction, mainly to visuospatial and spatial orientation skills, are surgical procedures, intra-periventricular hemorrhages, and multiple pregnancies.…”

Section: Discussionmentioning

confidence: 58%

Development of egocentric and allocentric spatial orientation abilities in children born preterm with very low birth weight

Fernández-Baizán

Alcántara-Canabal

Solı́s

et al. 2020

Early Human Development

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Background: very low birth weight preterm infants show neuropsychological alterations in functions such as memory or visuospatial skills, although certain related functions, such as spatial orientation, have not been studied. Objectives: to compare children born preterm and at term between the ages of 5 and 7 years on egocentric and allocentric spatial orientation, and relate their performance to visuospatial skills, behavior, memory in daily environments, and perinatal risk factors. Study design: observational cross-sectional study Subjects: 88 very low birth weight children born preterm and 59 controls. Outcome measures: IQ (RIST), visuospatial skills (NEPSY II: Route Finding and Geometric Puzzles), spatial orientation (Egocentric and Allocentric Spatial Memory Test-Children's Version), behavior (BASC questionnaire for parents), memory in everyday environments (ECM-Q questionnaire for parents), and perinatal risk factors (collected from medical records). Results: Children born preterm obtain significantly lower scores than controls on the RIST, Route Finding, and Allocentric Spatial Memory Tests. Although spatial orientation is related to other neuropsychological variables in both premature and control children, there is no meaningful association with behavior or daily memory in children born preterm. The perinatal risk factors that are associated the most with visuospatial and orientation problems are surgical procedures and peri-and intraventricular hemorrhages. Conclusions: Children born preterm with low birth weight present difficulties in their spatial orientation, and for this reason, we propose including these types of tasks in the usual neuropsychological evaluation.

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“…The developmental trajectory of twins was investigated either in term-born twins or preterm (PT) born ones, with the hypothesis that multiplicity would account for a unique portion of developmental outcome variance. 1 Twins represent 10% of PT birth in the United States (<37 weeks), more than 50% of twins birth are born PT, 2,3 and 11% of twins are PT (<32 weeks). 4 Moreover, the occurrence of multiple gestations is increasing since the advent of various artificial reproductive technologies, [5][6][7] and they remain the most common complication of assisted reproductive technology.…”

Section: Introductionmentioning

confidence: 99%

Early Psychomotor Advantage in Moderately Preterm Twins Born between 32 and 33 Weeks

Turriziani

Cafeo

Pino

et al. 2020

Journal of Pediatric Neurology

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Twin birth may represent a challenging event often associated with prematurity. We previously reported on developmental trajectories in preterm children categorized by gestational age. Based on the same study population, in this study we investigated the influence of gemellarity on the neurodevelopment of 73 twins (26.4%) and 207 singletons (73.6%), categorized into three groups according to their gestational age. The age of the achievement of developmental milestones between the three groups and the influence of preperinatal events on neurodevelopment were analyzed. An early neurodevelopmental advantage was detected in preterm twins born between 32 and 33 weeks. Environmental and nurturing factors may explain these findings.

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Neuropsychological Functioning in Preterm-Born Twins and Singletons at Preschool Age

Cited by 6 publications

References 35 publications

Neurodevelopmental Outcomes of Twins Compared With Singleton Children: A Systematic Review

Neurodevelopmental Outcomes of Twins Compared With Singleton Children: A Systematic Review

Development of egocentric and allocentric spatial orientation abilities in children born preterm with very low birth weight

Early Psychomotor Advantage in Moderately Preterm Twins Born between 32 and 33 Weeks

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