Neuropsychological functioning and age-related changes in schizophrenia and/or cocaine dependence

Benaiges, Irina; Serra-Grabulosa, Josep M.; Adán, Ana

doi:10.1016/j.pnpbp.2012.10.016

Cited by 16 publications

(15 citation statements)

References 49 publications

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“…Although precedent studies about neurocognition in DS are heterogeneous, it has been observed that DS patients are characterized by a worse global cognitive state [26], which is age-related, especially in executive performance [2, 3, 27] compared to single SZ. Regarding lifetime suicide attempts, in some studies that pointed out a better functioning in SZ patients with this condition related to the ability to initiate and plan suicidal behavior [29, 30], little information about the comorbidity with SUD was considered.…”

Section: Discussionmentioning

confidence: 99%

“…The result of the DS- group indicates that this is probably due to the necessity to obtain substances to maintain drug use in subjects with a stronger addiction [9, 28, 31], which could somehow mitigate their negative affectivity. Moreover, patients with greater severity of SUD require often treatment younger than those with less severity and, therefore, their cognitive functioning could be more preserved of the neurotoxic damage associated with the consumption [3, 31]. However, the results in the DS+ group suggest that negative symptoms may hinder planning for achieving life goals and quality of life [56], which in previous studies has been associated with suicide attempts [18].…”

Section: Discussionmentioning

confidence: 99%

“…Repeated measures multivariate analysis of variance (RM MANCOVA) was also used for the five blocks of the IGT direct scores. In all cases, we considered age as covariate to control for possible effects in cognitive performance because, although groups did not show differences, are known the age-related effects both in general population [50] and DS patients [2, 3]. We repeated all significant analyses including alcohol dependence also as covariate.…”

Section: Methodsmentioning

confidence: 99%

“…This dual diagnosis has relevant clinical implications, given that substance use could exacerbate the SZ symptoms [1] as well as the cognitive impairment [2, 3], it also worsens the prognosis of the disorder [4, 5], and increases the risk of suicide [6]. Thus, it is necessary to study new ways to improve the health-related quality of life and reducing mortality of DS patients.…”

Section: Introductionmentioning

confidence: 99%

“…Compared with the single condition, in the DS it has been observed a worse global cognitive state [26] with a marked deterioration with age, especially in executive performance [2, 3, 27], and it is considered to be a powerful predictor of maladaptive functioning [26]. Interestingly, higher premorbid intelligence quotient [17, 28], better executive [29, 30] and social premorbid functioning [18], and dysfunctional impulsivity [9, 19, 28] have been hypothesized to predispose for suicidal behavior and could facilitate the illegal substance acquisition.…”

Section: Introductionmentioning

confidence: 99%

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Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts

et al. 2017

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BackgroundLifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD), known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering as independent the presence or absence of lifetime suicide attempts.MethodsWe explore executive functioning differences between suicide attempters and non-attempters in dual schizophrenia (DS) patients and the possible related factors for both executive performance and current suicide risk. Fifty DS male patients in remission of SUD and clinically stables, 24 with and 26 without lifetime suicide attempts, were evaluated. We considered Z scores for all neuropsychological tests and a composite summary score for both premorbid IQ and executive functioning.ResultsDS patients showed low performance in set-shifting, planning and problem solving tasks. Those with suicide attempts presented lower composite summary scores, together with worse problem solving skills and decision-making, compared with non-attempters. However, after controlling for alcohol dependence, only differences in decision-making remained. Executive functioning was related to the premorbid intelligence quotient, and several clinical variables (duration, severity, months of abstinence and relapses of SUD, global functioning and negative symptoms). A relationship between current suicide risk, and first-degree relatives with SUD, insight and positive symptoms was also found.ConclusionsOur results suggest that problem solving and, especially, decision-making tasks might be sensitive to cognitive impairment of DS patients related to presence of lifetime suicide attempts. The assessment of these executive functions and cognitive remediation therapy when necessary could be beneficial for the effectiveness of treatment in patients with DS. However, further research is needed to expand our findings and overcome some limitations of this study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts

et al. 2017

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Circadian rhythmicity in schizophrenia male patients with and without substance use disorder comorbidity

Adán

Marquez-Arrico

Río-Martínez

et al. 2023

Eur Arch Psychiatry Clin Neurosci

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Circadian rhythmicity is associated to clinical variables that play an important role in both schizophrenia (SZ) and substance use disorders (SUD), although the characteristics of the coexistence of these two diagnoses (SZ +) remain mostly unknown. Hence, we studied a sample of 165 male patients divided in three groups each of 55, according to their diagnoses (SZ + , SZ, and SUD), as well as a healthy control (HC; n = 90) group. Alongside with sociodemographic and clinical variables, circadian rhythms were registered through a sleep–wake data structured interview, a circadian typology questionnaire, and distal skin temperature (DST) using the Thermochron iButton every 2 min during 48 h. Analyses showed that SZ + and SZ patients presented a longer sleep (delay in wake-up time) and mostly an intermediate circadian typology, while SUD patients slept less hours, displaying a morning typology. The DST showed the highest daily activation and stability for the SUD group, even when compared with the HC group. The presence of schizophrenia (SZ + and SZ) was related to a DST pattern with a reduced amplitude determined by a wakefulness impairment, which was more pronounced for SZ patients whose sleep period was adequate. The assessment of circadian rhythms in under treatment male patients with SZ should be focused on the diurnal period as a possible marker of either treatment adherence or patient's recovery, irrespective of the presence of a comorbid SUD. Further research with additional objective measures may provide knowledge transferable to therapeutic strategies and could be useful to establish possible endophenotypes in the future.

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Comorbidity between Substance Use Disorder and Severe Mental Illness

Adán

Benaiges

2016

Neuropathology of Drug Addictions and Substance Misuse

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Neuropsychological functioning and age-related changes in schizophrenia and/or cocaine dependence

Cited by 16 publications

References 49 publications

Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts

Executive Functioning in Men with Schizophrenia and Substance Use Disorders. Influence of Lifetime Suicide Attempts

Circadian rhythmicity in schizophrenia male patients with and without substance use disorder comorbidity

Comorbidity between Substance Use Disorder and Severe Mental Illness

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