Neuropsychological features of mind wandering in left-, right- and extra temporal lobe epilepsy

Luelsberg, Fabienne; Krakau, Sofie; Chaieb, Leila; Wrede, Randi von; Fell, Juergen; Helmstaedter, Christoph

doi:10.1016/j.seizure.2021.12.013

Cited by 3 publications

(4 citation statements)

References 46 publications

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“…A somewhat surprising finding was that our patient cohorts showed no statistically significant differences between verbal and nonverbal memory scores, although the left hemisphere of the brain is generally more associated with language processing, whereas the right is associated with visuospatial and constructional tasks. A similar observation was made by Luelsberg et al 51 . The reasons might lie in the rather small sample size of LTLE and RTLE patients and that it was assumed that right‐handed patients have a classical hemispheric functional organization, but no direct measure of hemispheric dominance was applied.…”

Section: Discussionsupporting

confidence: 64%

“…A similar observation was made by Luelsberg et al. 51 The reasons might lie in the rather small sample size of LTLE and RTLE patients and that it was assumed that right‐handed patients have a classical hemispheric functional organization, but no direct measure of hemispheric dominance was applied. Therefore, future investigations should aim for a higher number of patients and include measurements of patients' hemispheric lateralization with methods like language fMRI.…”

Section: Discussionsupporting

confidence: 62%

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Investigating the effect of hippocampal sclerosis on parietal memory network

Ethofer,

Milian,

Erb

et al. 2023

Epilepsia Open

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ObjectiveWe aimed to investigate differences in episodic memory networks between patients with temporal lobe epilepsy (TLE) due to hippocampal sclerosis and healthy controls, especially with regards to the parietal memory network (PMN), as well as their relation to neuropsychological memory performance after mesial temporal resection.Methods28 healthy subjects as well as 21 patients with TLE (12 left, 9 right) were investigated using a spatial memory fMRI paradigm, which has been shown to activate the PMN. Regions of interest (ROI) were defined based on the results of the second‐level analyses and activations within the predefined ROIs were compared across groups and correlated with postoperative verbal and nonverbal memory scores.ResultsHealthy subjects showed activations within regions belonging to the dorsal visual stream and the PMN as well as the bilateral parahippocampal place area, the bilateral frontal eye field, and the bilateral middle frontal gyrus. Comparison between groups revealed that TLE patients activated significantly less in the left middle occipital gyrus and the right precuneus. The activation pattern in left TLE patients showed further reductions, mainly in areas belonging to the dorsal visual stream and the PMN within the left hemisphere. Activations within the left superior parietal lobulus, bilateral inferior parietal lobulus, bilateral middle temporal gyrus, left precuneus, left frontal eye field, and left middle frontal gyrus correlated significantly with postoperative verbal memory scores, and activations within the left superior parietal lobulus, left inferior parietal lobulus, left middle temporal gyrus, and left precuneus correlated significantly with higher performance in postoperative nonverbal memory scores.SignificanceThe PMN is involved in episodic memory encoding. Higher activations in areas belonging to the PMN and the dorsal visual stream, especially within the left hemisphere, before amygdalohippocampectomy may result in higher postoperative memory scores.Plain language summaryThis study aims to investigate the effects of epilepsy due to hippocampal sclerosis, i.e. scarring in the temporal lobe, on memory networks in the brain. We discovered that especially patients with left‐sided hippocampal sclerosis show reduced brain activations in visual areas and memory networks within the left hemisphere of the brain during orientation in space. Importantly, higher activations within these areas may result in better memory after epilepsy surgery.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionsupporting

confidence: 62%

Investigating the effect of hippocampal sclerosis on parietal memory network

Ethofer,

Milian,

Erb

et al. 2023

Epilepsia Open

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“…Spontaneous-thought trials were found to be more frequent in the wake (75%), compared with N2 sleep (45%) and REM sleep (65%) [24]. It means that spontaneous thought primarily appears during wakefulness, but it could continue during sleep [17]. Sleep is a cortical-modification period at which both consolidation and activation of memories happen.…”

Section: Sleepmentioning

confidence: 99%

“…The significance of spontaneous thought should not be ignored since it occurs rather frequently in daily life. Spontaneous thoughts are the shift from the external environment to intrinsic ideas [27,29], occurring during wakefulness and sleep [17]. Research showed that humans would allocate 30-50% of their daytime for spontaneous thoughts and spend over 79.6% of their time in mind wandering-a form of spontaneous thought [27].…”

Section: Introductionmentioning

confidence: 99%

The Role of Spontaneous Thoughts in Human Cognition

Huang

2023

TNS

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Spontaneous thought is a cognitive process that ubiquitously happens in daily life. Humans spend 30-50% of their lives in spontaneous thinking, but the impact and consequence of spontaneous thought have not been widely studied in cognitive neuroscience. It is crucial to expand the research involving spontaneous thought since it benefits human's memory encoding and decision-making abilities. This review has two main aims: the first is to explore the cognitive impact of goal-directed and spontaneous thought; the second is to discover the benefits of spontaneous thought to humans. This paper concludes that spontaneous thought has the role of improving memory encoding and facilitating future planning.

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Resting-State Functional Magnetic Resonance Imaging as an Indicator of Neuropsychological Changes in Type 1 Narcolepsy

Xu,

Xue,

et al. 2024

Academic Radiology

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Neuropsychological features of mind wandering in left-, right- and extra temporal lobe epilepsy

Cited by 3 publications

References 46 publications

Investigating the effect of hippocampal sclerosis on parietal memory network

Investigating the effect of hippocampal sclerosis on parietal memory network

The Role of Spontaneous Thoughts in Human Cognition

Resting-State Functional Magnetic Resonance Imaging as an Indicator of Neuropsychological Changes in Type 1 Narcolepsy

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