Neuropsychological evidence for abnormal neurodevelopment associated with early-onset psychoses

Bombín, Igor; Mayoral, María; Castro‐Fornieles, Josefina; González-Pinto, Ana; Serna, Elena de la; Rapado-Castro, Marta; Barbeito, Sara; Parellada, Mara; Baeza, Inmaculada; Graell, Montserrat; Paya, Beatríz; Arango, Celso

doi:10.1017/s0033291712001535

Cited by 55 publications

(54 citation statements)

References 48 publications

(62 reference statements)

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“…52 In line with the possibility that patients with psychosis have a particularly degenerative or deteriorating outcome, first-episode early-onset psychosis patients have been shown to have low antioxidant status, with no differences between schizophrenia and bipolar patients; however only those with schizophrenia have lower glutathione at baseline. 74 In terms of cognition, the impairment seems to remain similar during the first 2 years after the first psychotic episode in bipolar and schizophrenia patients, 23 with cognitive reserve (composed of an estimation of premorbid IQ and a measure of educational-occupational levels and lifetime leisure-social activities) predicting long-term working memory and attention.…”

Section: What Happens After a First Psychotic Episode In Children Andmentioning

confidence: 98%

“…23,24 The discrepancy between the data showing cognitive impairment in bipolar disorder and close relatives [25][26][27][28] and the better premorbid cognitive functioning and scholastic performance in longitudinal studies in subjects who end up having adult bipolar disorder could be due to sample selection bias, medication, drug use, cognitive decline prior to the first psychotic episode, or other confounding factors. Reading difficulties and scholastic underachievement, however, seem to be more specific to early-onset schizophrenia than early-onset bipolar I disorder.…”

Section: Cognitive Impairment During Development In Schizophrenia Andmentioning

confidence: 99%

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Differential Neurodevelopmental Trajectories in Patients With Early-Onset Bipolar and Schizophrenia Disorders

Arango¹,

Fraguas

Parellada

2013

Schizophrenia Bulletin

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106

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Schizophrenia and bipolar disorders share not only clinical features but also some risk factors such as genetic markers and childhood adversity, while other risk factors such as urbanicity and obstetric complications seem to be specific to schizophrenia. An intriguing question is whether the wellestablished abnormal neurodevelopment present in many children and adolescents who eventually develop schizophrenia is also present in bipolar patients. The literature on adult bipolar patients is controversial. We report data on a subgroup of patients with pediatric-onset psychotic bipolar disorder who seem to share some developmental trajectories with patients with early-onset schizophrenia. These earlyonset psychotic bipolar patients have low intelligence quotient, more neurological signs, reduced frontal gray matter at the time of their first psychotic episode, and greater brain changes than healthy controls in a pattern similar to earlyonset schizophrenia cases. However, patients with earlyonset schizophrenia seem to have more social impairment, developmental abnormalities (eg, language problems), and lower academic achievement in childhood than early-onset bipolar patients. We suggest that some of these abnormal developmental trajectories are more related to the phenotypic features (eg, early-onset psychotic symptoms) of these 2 syndromes than to categorically defined Diagnostic and Statistical Manual of Mental Disorders disorders.

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Section: What Happens After a First Psychotic Episode In Children Andmentioning

confidence: 98%

Section: Cognitive Impairment During Development In Schizophrenia Andmentioning

confidence: 99%

Differential Neurodevelopmental Trajectories in Patients With Early-Onset Bipolar and Schizophrenia Disorders

Arango¹,

Fraguas

Parellada

2013

Schizophrenia Bulletin

Self Cite

106

View full text Add to dashboard Cite

show abstract

“…Two studies on late-onset BD did not find a relationship between cognitive decline, severity of symptoms, and duration illness [36,37]. Other studies concluded that there was little to no evidence that deficits in cognitive domains such as psychomotor speed, verbal memory, and executive functions were associated with markers of illness progression in BD [38][39][40][41][42][43][44][45].…”

Section: Cognitive Decline In Bipolar Disordermentioning

confidence: 99%

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Cardoso

Bauer

Meyer

et al. 2015

Curr Psychiatry Rep

126

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Bipolar disorder (BD) has been associated with impairments in a range of cognitive domains including attention, verbal learning, and mental flexibility. These deficits are increased during the acute phases of the illness and worsen over the course of BD. This review will examine the literature in relation to potential mechanisms associated with cognitive decline in BD. Scopus (all databases), Pubmed, and Ovid Medline were systematically searched with no language or year restrictions, up to January 2015, for human studies that collected cross-sectional and longitudinal cognitive data in adults with BD and matched healthy controls (HC). Selected search terms were "bipolar," "cognitive," "aging," "illness duration," "onset," and "progression." Thirty-nine studies satisfied the criteria for consideration. There is evidence that cognitive function in BD is negatively associated with features of illness progression such as number of mood episodes, illness duration, and hospitalizations. Aging does not appear to affect cognitive functioning to a greater extent than in HC. Furthermore, the small number of longitudinal studies in this field does not allow to reaching firm conclusion in terms of which sub-populations would be more prone to cognitive decline in BD. The decline in cognitive abilities over the course of the BD seems to be associated with the number of episodes and number of hospitalizations. No meaningful interaction of age and bipolar disorder has been found in terms of cognitive decline. Future large-scale longitudinal studies are necessary to confirm these findings and assist in the development of preventive interventions in vulnerable individuals.

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“…Therefore, some authors suggested that severe mood symptoms could act like stress-induced neurotoxins (Lopez-Jaramillo et al, 2010). In contrast, other studies found that first-episode BP patients have the same neurocognitive performance as patients with multiple episodes in the past (Bombin et al, 2013;Hellvin et al, 2012). Torrent et al (2012) described in a recently published longitudinal study that cognitive impairments (except for a worsening of executive functions) remained stable over nine years, irrespective of severe relapses in the meantime.…”

Section: Introductionmentioning

confidence: 99%

Evidence for cognitive subgroups in bipolar disorder and the influence of subclinical depression and sleep disturbances

Volkert

Kopf

Kazmaier

et al. 2015

European Neuropsychopharmacology

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Neuropsychological evidence for abnormal neurodevelopment associated with early-onset psychoses

Cited by 55 publications

References 48 publications

Differential Neurodevelopmental Trajectories in Patients With Early-Onset Bipolar and Schizophrenia Disorders

Differential Neurodevelopmental Trajectories in Patients With Early-Onset Bipolar and Schizophrenia Disorders

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Evidence for cognitive subgroups in bipolar disorder and the influence of subclinical depression and sleep disturbances

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