Neuropsychological deficits after a first unprovoked seizure and depressive symptoms in the week before

Rühle, Nicol; Schley, A.; Pohley, I.; Kampf, Christina; Benecke, R.; Rösche, Johannes

doi:10.1016/j.yebeh.2013.10.007

Cited by 6 publications

(22 citation statements)

References 18 publications

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“…Large scale clinical studies, using the new ILAE classification of HS, will likely contribute to a better understanding of the respective contribution of each ''hit'' to the development of HS. Such studies will also allow to better understand the role of brain lesions that sometimes precede the occurrence of the first epileptogenic event (CFS mostly before the age of 4), and/or the role of depression or stress that often precede the first seizures in adults or adolescents [31,[121][122][123]. It appears therefore necessary to further develop and use ''two-hit'' animal models to better identify the influence of each insult, the way it contributes to the epileptogenic process, and at which timepoint of epileptogenesis their influence is critical.…”

Section: Resultsmentioning

confidence: 99%

Revisiting hippocampal sclerosis in mesial temporal lobe epilepsy according to the “two-hit” hypothesis

Hamelin

Depaulis

2015

Revue Neurologique

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Section: Resultsmentioning

confidence: 99%

Revisiting hippocampal sclerosis in mesial temporal lobe epilepsy according to the “two-hit” hypothesis

Hamelin

Depaulis

2015

Revue Neurologique

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“…Our data are mainly in agreement with the published literature indicating that verbal memory deficit are commonly present even at the time of a first unprovoked seizure. 21 Ruhle et al evaluated psychometric characteristics of 53 patients with first unprovoked seizure and demonstrated verbal memory (60%), non-verbal memory (30%) and executive (32%) dysfunctions in the participants. 21 Baker et al investigated 147 patients with newly diagnosed epilepsy from SANAD study over the first 12 months of antiepileptic drugs treatment with neuropsychological tests; patients performed worse than healthy volunteers particularly in psychomotor speed, higher executive functioning, and memory.…”

Section: Discussionmentioning

confidence: 99%

“…21 Ruhle et al evaluated psychometric characteristics of 53 patients with first unprovoked seizure and demonstrated verbal memory (60%), non-verbal memory (30%) and executive (32%) dysfunctions in the participants. 21 Baker et al investigated 147 patients with newly diagnosed epilepsy from SANAD study over the first 12 months of antiepileptic drugs treatment with neuropsychological tests; patients performed worse than healthy volunteers particularly in psychomotor speed, higher executive functioning, and memory. 11,22 Taylor et al found that untreated patients with newly diagnosed epilepsy appeared weaker in 6 out of 14 cognitive measures of neuropsychological battery particularly in the domains of memory and psychomotor speed compared to healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, Ruhle et al indicated memory deficits were not improved when the patients were evaluated with a delay of some days after seizure onset. 21 Therefore, memory dysfunction in newly diagnosed epilepsy cannot be attributed to attentional deficit; it is an independent, probably irreversible pathologic process indicating the presence of an active epileptogenic focus. However, these cognitive signs do not predict seizure recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive deficits in the first 24 hours after the onset of first unprovoked generalized Tonic and clonic seizure

Charmchi

Sayadnasiri

2017

International Journal of Epilepsy

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Background Many people with epilepsy suffer from cognitive deficits as a consequence of their seizure episodes. Relatively few researches have been undertaken to assess the short term impacts of seizure on cognitive function. This study aimed to evaluate changes in cognitive performance in adults with a new onset generalized seizure in the first 24 h after the onset of their attack.Methods After having given informed consent, 40 patients with first episode of unprovoked generalized tonic-clonic seizure were investigated with a neuropsychological test battery (Wechsler Memory Scale III). Their performance was compared with 40 healthy individuals from the patients' companions.Results Newly diagnosed patients had significantly worse performance in paired association recall which is a parameter of verbal memory; other memory parameters showed no significant changes after seizure attack.Conclusion Our data suggested that even with a one-time seizure episode, patients are susceptible to verbal memory impairment.

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“…Overall, 16 studies reported prevalence of clinically significant anxiety and depressive symptoms in people with first seizures and/or newly diagnosed epilepsy. Fourteen [7][8][9][10][11][12][13][14][15][16][17][18][19][20] were cohort studies and two 21,22 were randomized controlled trials. Three 13,18,19 studies considered first seizure cohorts exclusively (Table 1), eight 17,[23][24][25][26][27][28][29] considered newly diagnosed epilepsy cohorts exclusively (Table 2), and five 21,22,[30][31][32] considered both first seizure and newly diagnosed epilepsy cohorts (Table 3).…”

Section: Description Of Included Studiesmentioning

confidence: 99%

Anxiety and depressive symptoms in adults with new‐onset seizures: A scoping review

2023

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ObjectiveAnxiety and depression are common comorbidities in people living with epilepsy. Emerging research suggests that these conditions may even predate epilepsy onset. This review aimed to summarize the prevalence of clinically significant anxiety and depressive symptoms in people with first seizures and newly diagnosed epilepsy, as well as clinicodemographic factors associated with these symptoms.MethodsA scoping literature review was performed. OVID Medline and Embase were searched from January 1, 2000, through May 1, 2022. Articles of interest were selected based on predetermined inclusion and exclusion criteria.ResultsFrom 1836 studies identified on screening, 16 met eligibility criteria and were included in the review. Clinically significant anxiety and depressive symptoms, as determined by validated cutoff scores for anxiety and depression screening instruments, were common in people with first seizures (range 13–28%) and newly diagnosed epilepsy (range 11–45%). They were associated with a range of clinicodemographic factors including past psychiatric history and trauma, personality traits, self‐esteem, and stigma profiles.SignificanceThere is substantial evidence that clinically significant anxiety and depressive symptoms are often present at the time and shortly following the first seizure or epilepsy diagnosis. Future research is needed to better understand the complex interactions between these common psychiatric comorbidities, new‐onset seizure disorders, and certain clinicodemographic characteristics. This knowledge may inform targeted and holistic treatment approaches.

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Neuropsychological deficits after a first unprovoked seizure and depressive symptoms in the week before

Cited by 6 publications

References 18 publications

Revisiting hippocampal sclerosis in mesial temporal lobe epilepsy according to the “two-hit” hypothesis

Revisiting hippocampal sclerosis in mesial temporal lobe epilepsy according to the “two-hit” hypothesis

Cognitive deficits in the first 24 hours after the onset of first unprovoked generalized Tonic and clonic seizure

Anxiety and depressive symptoms in adults with new‐onset seizures: A scoping review

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