Neuropsychological consequences of pallidal deep brain stimulation altering brain networks

Huh, Ryoong; Song, In‐Uk; Chung, Moonyoung

doi:10.1016/j.jocn.2018.05.004

Cited by 13 publications

(13 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, a very similar prefrontal network, along with the IPC, was found in a meta-analysis of activations in go/no-go tasks. 66 One study reported postoperatively impaired Stroop test performance as an isolated cognitive change, 67 but reviews concluded that cognition is normal in dystonia before 16 and after GPi-DBS. 53…”

Section: Normalization Of Sensorimotor Cortical Activationmentioning

confidence: 99%

Pallidal Deep Brain Stimulation Reduces Sensorimotor Cortex Activation in Focal/Segmental Dystonia

et al. 2020

View full text Add to dashboard Cite

Background Although deep brain stimulation of the globus pallidus internus (GPi‐DBS) is an established treatment for many forms of dystonia, including generalized as well as focal forms, its effects on brain (dys‐)function remain to be elucidated, particularly for focal and segmental dystonia. Clinical response to GPi‐DBS typically comes with some delay and lasts up to several days, sometimes even weeks, once stimulation is discontinued. Objective This study investigated how neural activity during rest and motor activation is affected by GPi‐DBS while excluding the potential confound of altered feedback as a result of therapy‐induced differences in dystonic muscle contractions. Methods Two groups of patients with focal or segmental dystonia were included in the study: 6 patients with GPi‐DBS and 8 without DBS (control group). All 14 patients had cervical dystonia. Using H215O PET, regional cerebral blood flow was measured at rest and during a motor task performed with a nondystonic hand. Results In patients with GPi‐DBS (stimulation ON and OFF), activity at rest was reduced in a prefrontal network, and during the motor task, sensorimotor cortex activity was lower than in patients without DBS. Within‐group contrasts (tapping > rest) showed less extensive task‐induced motor network activation in GPi‐DBS patients than in non‐DBS controls. Reduced sensorimotor activation amounted to a significant group‐by‐task interaction only in the stimulation ON state. Conclusions These findings support previous observations in generalized dystonia that suggested that GPi‐DBS normalizes dystonia‐associated sensorimotor and prefrontal hyperactivity, indicating similar mechanisms in generalized and focal or segmental dystonia. Evidence is provided that these effects extend into the OFF state, which was not previously demonstrated by neuroimaging. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

show abstract

Section: Normalization Of Sensorimotor Cortical Activationmentioning

confidence: 99%

Pallidal Deep Brain Stimulation Reduces Sensorimotor Cortex Activation in Focal/Segmental Dystonia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In the studies addressing clinical effects of the GPi DBS on dystonia patients, pain reduction was consistently reported after pallidal stimulation [ 33 , 56 ]. Interestingly, analgesic effect of the GPi DBS showed a tolerance indicating a partial loss of initial pain reduction in long-term follow-up, while the anti-dystonic effects had a delayed benefit, i.e., a progressive increase in the therapeutic benefits in dystonia [ 17 , 32 ]. These mutually conflicting clinical course means that the therapeutic effects of the GPi DBS for pain and dystonia are achieved through different mechanisms in the brain [ 32 ].…”

Section: Potential Targets For Neuromodulation Of Trigeminal Neuralgiamentioning

confidence: 99%

Neuromodulation for Trigeminal Neuralgia

Chung

Huh

2022

J Korean Neurosurg Soc

Self Cite

View full text Add to dashboard Cite

Clinical studies on neuromodulation intervention for trigeminal neuralgia have not yet shown promising results. This might be due to the fact that the pathophysiology of chronic trigeminal neuropathy is not yet fully understood. Chronic trigeminal neuropathy includes trigeminal autonomic neuropathy, painful trigeminal neuropathy, and persistent idiopathic facial pain. This disorder is caused by complex abnormalities in the pain processing system, which is comprised of the affective, emotional, and sensory components, rather than mere abnormal sensation. Therefore, integrative understanding of the pain system is necessary for appropriate neuromodulation of chronic trigeminal neuropathy. The possible neuromodulation targets that participate in complex pain processing are as follows : the ventral posterior medial nucleus, periaqueductal gray, motor cortex, nucleus accumbens, subthalamic nucleus, globus pallidus internus, anterior cingulate cortex, hypothalamus, sphenopalatine ganglion, and occipital nerve. In conclusion, neuromodulation interventions for trigeminal neuralgia is yet to be elucidated; future advancements in this area are required

show abstract

“…3; b) to recipient nucleus, so that it may renders impairments in sensorimotor function such as dysarthria, and gait disturbance [65]. In this situation, reductions in the amplitude or pulse width may ameliorate these side effects [66]. The most common side effect of GPi DBS is dysarthria.…”

Section: The Follow-up Programming For Globus Pallidus Internus Deep Brain Stimulationmentioning

confidence: 99%

Theoretical considerations of deep brain stimulation programming

Chung

2021

J Korean Ster Func Neurosurg

Self Cite

View full text Add to dashboard Cite

Deep brain stimulation (DBS) is an effective surgical option for medically intractable movement disorders. Adjustment of DBS parameters is the only modifiable factor that affects the clinical outcomes of DBS. It is very important to understand the basic functions of the basal ganglia and thalamus for successful DBS programming. The amplitude, frequency, and pulse width define the volume of tissue activated, the pattern of artificial action potentials, and the selectivity of activated neural elements, respectively. Based on this knowledge, it is possible to obtain the maximum clinical benefits and minimum side effects by appropriately adjusting the electrical stimulation to the target structure.

show abstract

Neuropsychological consequences of pallidal deep brain stimulation altering brain networks

Cited by 13 publications

References 55 publications

Pallidal Deep Brain Stimulation Reduces Sensorimotor Cortex Activation in Focal/Segmental Dystonia

Pallidal Deep Brain Stimulation Reduces Sensorimotor Cortex Activation in Focal/Segmental Dystonia

Neuromodulation for Trigeminal Neuralgia

Theoretical considerations of deep brain stimulation programming

Contact Info

Product

Resources

About