Neuropsychological assessment of persons with physical disability, visual impairment or blindness, and hearing impairment or deafness

Hill-Briggs, Felicia; Dial, Jack G.; Morere, Donna A.; Joyce, Arthur

doi:10.1016/j.acn.2007.01.013

Cited by 102 publications

(84 citation statements)

References 67 publications

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“…Furthermore, other authors have also found changes in subjects' spatial and temporal senses and their relation with objects after vision loss. [23][24][25][26] In terms of the adjustment process, our sample also focused on different themes of the recovery process in comparison with the older adults previously studied. Most of rehabilitation goals were not only focused on recovery of basic skills and autonomy, but also on the acquisition of new skills to allow a return to work and to realize new projects for future life.…”

Section: Discussionmentioning

confidence: 99%

From self-awareness to self-identification with visual impairment: a qualitative study with working age adults at a rehabilitation setting

2011

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Objective: To explore the experience of vision loss, focusing on working age patients' self-awareness of impairment and self-identification with the impairment. Design: A cross-sectional and qualitative study, using semi-structured interviews. Setting: A specialized rehabilitation centre and a low vision unit at a public hospital. Participants: A convenience sample of 38 patients between the ages of 20 and 65, with sight loss caused by a serious ophthalmological condition acquired after the age of 18, and doing their rehabilitation. Main outcome measures: A semi-structured interview, addressing three core areas: the emotional impact of vision loss; adjustment; and social support. Interviews were transcribed, coded and analysed by two independent researchers. Results: Seven themes emerged from interviews. Changes in patients' identity, achievement and future life projection arose as being the main transformations caused by vision loss. Self-awareness of impairment appeared associated with the patients' first contact with their loss, while self-identification with the impairment arose connected with the later embodiment process of the vision loss. Conclusions: Patients' self-awareness and self-perceptions of impairment appear to be two important milestones in the adjustment process to vision loss. Their assessment and monitoring over the rehabilitation period might help to promote impairment acceptance and rehabilitation outcomes.

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Section: Discussionmentioning

confidence: 99%

From self-awareness to self-identification with visual impairment: a qualitative study with working age adults at a rehabilitation setting

2011

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“…The challenge of assessing neuropsychological functioning using tests requiring the use of upper extremities in persons with paralyzed limbs has been reported in the literature 59 . However, non-significant results were still seen when excluding patients with upper limb limitations.…”

Section: Discussionmentioning

confidence: 99%

“…Quadriplegic participants were instructed to use their best grip to hold pens (digit symbol and trail making test) or pins (grooved pegboard) where applicable. However, some participants were not able to complete testing because of the severity of their disability, a problem identified in the literature 59 .…”

Section: Methodsmentioning

confidence: 99%

An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease

Wilsey

Marcotte

Deutsch

et al. 2016

The Journal of Pain

114

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Using eight hour human laboratory experiments, we evaluated the analgesic efficacy of vaporized cannabis in patients with neuropathic pain related to injury or disease of the spinal cord, the majority of whom were experiencing pain despite traditional treatment. After obtaining baseline data, 42 participants underwent a standardized procedure for inhaling 4 puffs of vaporized cannabis containing either placebo, 2.9%, or 6.7% delta-9-tetrahydrocannabinol on three separate occasions. A second dosing occurred 3 hours later; participants chose to inhale 4 to 8 puffs. This flexible dosing was utilized to attempt to reduce the placebo effect. Using an 11-point numerical pain intensity rating scale as the primary outcome, a mixed effects linear regression model demonstrated a significant analgesic response for vaporized cannabis. When subjective and psychoactive side effects (e.g., good drug effect, feeling high, etc.) were added as covariates to the model, the reduction in pain intensity remained significant above and beyond any effect of these measures (all p<0.0004). Psychoactive and subjective effects were dose dependent. Measurement of neuropsychological performance proved challenging because of various disabilities in the population studied. As the two active doses did not significantly differ from each other in terms of analgesic potency, the lower dose appears to offer the best risk-benefit ratio in patients with neuropathic pain associated with injury or disease of the spinal cord.

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“…In the current study, we performed standard diagnostic neurocognitive testing in a cross-sectional cohort of 28 children and adults with WAGR syndrome and observed that BDNF haploinsufficiency was associated with lower adaptive behaviour and cognitive functioning, even after accounting for visual impairment, which can be an important confounding factor (Hill-Briggs et al, 2007). While previous case series have described cognitive impairment in individuals with BDNF haploinsufficiency, our study is the first to compare subjects having 11p13 deletions, with and without BDNF involvement, using a systematic diagnostic approach to correlate genotype with neurocognitive phenotype.…”

Section: Discussionmentioning

confidence: 99%

Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome

Han

Thurm

Williams

et al. 2013

Cortex

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In animal studies, brain-derived neurotrophic factor (BDNF) is an important regulator of central nervous system development and synaptic plasticity. WAGR (Wilms tumour, Aniridia, Genitourinary anomalies, and mental Retardation) syndrome is caused by 11p13 deletions of variable size near the BDNF locus and can serve as a model for studying human BDNF haploinsufficiency (+/−). We hypothesized that BDNF+/− would be associated with more severe cognitive impairment in subjects with WAGR syndrome. Twenty-eight subjects with WAGR syndrome (6–28y), 12 subjects with isolated aniridia due to PAX6 mutations/microdeletions (7–54y), and 20 healthy controls (4–32y) received neurocognitive assessments. Deletion boundaries for the subjects in the WAGR group were determined by high resolution oligonucleotide array comparative genomic hybridization. Within the WAGR group, BDNF+/− subjects (n=15), compared with BDNF intact (+/+) subjects (n=13), had lower adaptive behaviour (p=.02), reduced cognitive functioning (p=.04), higher levels of reported historical (p=.02) and current (p=.02) social impairment, and higher percentage meeting cut-off score for autism (p=.047) on Autism Diagnostic Interview-Revised. These differences remained nominally significant after adjusting for visual acuity. Using diagnostic measures and clinical judgment, 3 subjects (2 BDNF+/− and 1 BDNF+/+) in the WAGR group (10.7%) were classified with autism spectrum disorder. A comparison group of visually impaired subjects with isolated aniridia had cognitive functioning comparable to that of healthy controls. In summary, among subjects with WAGR syndrome, BDNF+/− subjects had a mean Vineland Adaptive Behaviour Compose score that was 14 points lower and a mean IQ that was 20 points lower than BDNF+/+ subjects. Our findings support the hypothesis that BDNF plays an important role in human neurocognitive development.

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Neuropsychological assessment of persons with physical disability, visual impairment or blindness, and hearing impairment or deafness

Cited by 102 publications

References 67 publications

From self-awareness to self-identification with visual impairment: a qualitative study with working age adults at a rehabilitation setting

From self-awareness to self-identification with visual impairment: a qualitative study with working age adults at a rehabilitation setting

An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease

Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome

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