Neuropsychological Assessment in Kidney and Liver Transplantation Candidates

Lacerda, Sheylla Nadjane Batista; Guimaro, Melissa Simon; Prade, C.V.; Ferraz-Neto, Ben Hur; Karam, CH; Andreoli, Paola Bruno Araújo

doi:10.1016/j.transproceed.2008.02.042

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…Similar to findings from our study, deficits in focused attention were found to be most strongly associated with CKD severity and lower education levels as well as older age. This pattern of findings also has been found for adult patients with ESKD who were awaiting a kidney transplant with dialysis-dependency (Lacerda et al, 2008), with the findings in the current study mirroring these findings as shown by our ESKD Group. Other adult studies on ESKD populations, however, have been inconclusive, with difficulties identified more frequently for processing speed and reaction time (Jassal et al, 2008) more so than for selective or sustained attention (Umans and Pliskin, 1998).…”

Section: Discussionsupporting

confidence: 90%

Differential Attention Functioning in Pediatric Chronic Kidney Disease

Duquette

Gipson

Hooper

2022

Front. Hum. Neurosci.

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ObjectiveTo compare specific attention functions for school-age children with chronic kidney disease (CKD) to those of a typically developing control group.MethodsA cross-sectional study examined attention dimensions for children and adolescents with CKD (n = 30) in comparison to a typically developing control group (n = 41). The CKD group consisted of those receiving maintenance dialysis (n = 15) and those with mild/moderate CKD treated conservatively (n = 15). Measures aligning with Mirsky’s conceptual multidimensional model of attention were selected to compare groups across five dimensions of attention: Focus/Execute, Sustain, Stability, Shift, and Encode.ResultsSignificant group differences were revealed, with the CKD group performing worse than controls on the Focus/Execute, Sustain, and Encode dimensions. The CKD group also had a larger proportion of children with scores one standard deviation or more below the mean on the Shift and Encode domains, suggesting an at-risk level of functioning in these dimensions. Secondary analyses showed disease severity to be correlated with worse attention functions for children with CKD.ConclusionChildren with CKD may be vulnerable to subtle, specific deficits in numerous attention dimensions relative to their typically developing peers, particularly for those with more severe disease.

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Section: Discussionsupporting

confidence: 90%

Differential Attention Functioning in Pediatric Chronic Kidney Disease

Duquette

Gipson

Hooper

2022

Front. Hum. Neurosci.

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“…When evaluating the cognition of TCs, objective assessment measures are necessary to accurately identify cognitive impairment because clinician perception of cognitive impairment is frequently inaccurate (Gupta et al, 2018). Depending on the setting and specific concerns about the TC, cognition may be assessed in a number of ways, ranging from brief screeners such as the Montreal Cognitive Assessment (Szymkowicz et al, 2021) to multidomain measures such as the Repeatable Battery of Neuropsychological Status (Mooney et al, 2007), or a full battery of neuropsychological assessments tailored to the TC (Lacerda et al, 2008;Roman, 2018). Providing feedback from cognitive testing and making recommendations (e.g., communication and compensatory strategies) to TCs and their caregiver(s) during the PPAs may reduce posttransplant nonadherence (Cheng et al, 2012).…”

Section: Cognitive Functioningmentioning

confidence: 99%

Solid organ transplant.

Balliet¹,

Haver²,

Maurer³

et al. 2023

Psychological Assessment of Surgical Candidates: Evidence-Based Procedures and Practices.

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Although solid organ transplantation (SOT) is considered one of the exceptional medical victories of the 20th century, there is a widening gap between available organs and potential recipients. In the United States, every 9 minutes, another person is added to the transplant waitlist, and on average, 17 people die per day while waiting to receive SOT (Health Resources and Services Administration, 2021). As a result, transplant teams are often considered custodians of this limited and valued resource for patients with advanced or end-stage organ disease (ESOD). This chapter focuses on areas most applicable to the presurgical psychosocial assessment of adult SOT candidates (PPA-TC), incorporating a brief review of the distinct domains across the four most common organ transplants and associated disease states. Pretransplant psychosocial, behavioral, and cognitive factors that have been empirically linked to posttransplant outcomes are reviewed to help guide why and how to best assess adult patients being considered for liver, heart, lung, or kidney transplantation (LT, HT, LGT, KT, respectively). Guidelines for evaluating

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“…28,29 In recent evaluations of patients presenting for a liver transplant, significant decrements were identified in nearly all domains of cognitive function. [30][31][32] Encephalopathy of varying severity is present in a high proportion of patients with endstage renal disease, and therefore in those who have been listed for a kidney transplant; commonly encountered presentations include uremic encephalopathy 33 and dialysis disequilibrium syndrome. 34 Among candidates for HCST, a significant proportion have neurological or cognitive impairment which preexists the transplant and can be due to neurological involvement from the underlying disease, neurotoxicity of pretransplant radiation and chemotherapy, opportunistic infections, or intracranial hemorrhage.…”

Section: Neurological Dysfunction Preceding Transplantationmentioning

confidence: 99%

Analytic Review: Neurological Complications of Transplantation

Pustavoitau

Bhardwaj

Stevens

2011

J Intensive Care Med

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Recipients of solid organ or hematopoietic cell transplants are at risk of life-threatening neurological disorders including encephalopathy, seizures, infections and tumors of the central nervous system, stroke, central pontine myelinolysis, and neuromuscular disorders-often requiring admission to, or occurring in, the intensive care unit (ICU). Many of these complications are linked directly or indirectly to immunosuppressive therapy. However, neurological disorders may also result from graft versus host disease, or be an expression of the underlying disease which prompted transplantation, as well as injury induced during radiation, chemotherapy, surgery, and ICU stay. In rare cases, neuroinfectious pathogens may be transmitted with the transplanted tissue or organ. Diagnosis may be a challenge because clinical symptoms and findings on neuroimaging lack specificity, and a biological specimen or tissue diagnosis is often needed for definitive diagnosis. Management is centered on preventing further neurological injury, etiology-targeted therapy, and balancing the benefits and toxicities of specific immunosuppressive agents.

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Neuropsychological Assessment in Kidney and Liver Transplantation Candidates

Cited by 8 publications

References 7 publications

Differential Attention Functioning in Pediatric Chronic Kidney Disease

Differential Attention Functioning in Pediatric Chronic Kidney Disease

Solid organ transplant.

Analytic Review: Neurological Complications of Transplantation

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