Neuropsychological Assessment and Screening in Heart Failure: a Meta-Analysis and Systematic Review

Connors, Eric J; Hauson, Alexander O; Barlet, Brianna D; Sarkissians, Sharis; Stelmach, N; Walker, Alyssa D; Nemanim, Natasha; Greenwood, Kristina L.; Chesher, Nicholas J.; Wollman, Scott C; Allen, Kenneth E.; Hall, Matthew; Flora-Tostado, Christopher

doi:10.1007/s11065-020-09463-3

Cited by 14 publications

(7 citation statements)

References 73 publications

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“…CI was previously thought to be limited to older patients with HF, but has since been described in younger HF populations as well [ 16 , 17 ]. While the prevalence of CI in HF has been reported in many studies, there is significant heterogeneity in the existing literature [ 9 , 17 , 18 ]. Patient populations are diverse, with some studies including patients with stable, chronic HF [ 19 , 20 ] and others including those with acute decompensated HF [ 3 , 5 , 8 ].…”

Section: Epidemiology Of Hf and Prevalence Of CImentioning

confidence: 99%

“…Compared to healthy controls, patients with HF demonstrate reduced global cognition as well as deficits in multiple cognitive domains including executive function, psychomotor speed and verbal memory [ 9 ]. Sterling et al found that the prevalence of CI among patients with incident HF (14.9%) was similar to controls without HF (13.4%) and was lower than reported in the general HF population.…”

Section: Cognitive Changes In Hfmentioning

confidence: 99%

“…The Mini-Cog is a quicker test and may be useful in dementia but is limited in mild CI [ 106 ]. More comprehensive testing in selected high-risk patients may be useful, and patients with HF performed especially poorly in the Trail Making Test B, Symbol Digit Modality Test and California Verbal Learning Test compared to controls [ 9 ]. However, there are currently no guidelines on screening for CI in HF.…”

Section: Screening For CI In Patients With Hfmentioning

confidence: 99%

“…Cognitive impairment (CI) in patients with heart failure (HF) is common, with a reported prevalence of 20–80% [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Patients with HF demonstrate increased cognitive deficits compared to controls in several cognitive domains [ 9 ] and have poorer self-care and treatment adherence [ 10 ]. Cerebrovascular haemodynamics and structural brain changes have been postulated to contribute to the cognitive deficits seen in patients with HF [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Cognitive Impairment in Heart Failure—A Review

Goh

Kong

Wong

et al. 2022

Biology

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Cognitive impairment (CI) is common in heart failure (HF). Patients with HF demonstrate reduced global cognition as well as deficits in multiple cognitive domains compared to controls. Degree of CI may be related to HF severity. HF has also been associated with an increased risk of dementia. Anatomical brain changes have been observed in patients with HF, including grey matter atrophy and increased white matter lesions. Patients with HF and CI have poorer functional independence and self-care, more frequent rehospitalisations as well as increased mortality. Pathophysiological pathways linking HF and CI have been proposed, including cerebral hypoperfusion and impaired cerebrovascular autoregulation, systemic inflammation, proteotoxicity and thromboembolic disease. However, these mechanisms are poorly understood. We conducted a search on MEDLINE, Embase and Scopus for original research exploring the connection between HF and CI. We then reviewed the relevant literature and discuss the associations between HF and CI, the patterns of brain injury in HF and their potential mechanisms, as well as the recognition and management of CI in patients with HF.

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Section: Epidemiology Of Hf and Prevalence Of CImentioning

confidence: 99%

Section: Cognitive Changes In Hfmentioning

confidence: 99%

Section: Screening For CI In Patients With Hfmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cognitive Impairment in Heart Failure—A Review

Goh

Kong

Wong

et al. 2022

Biology

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“…С диагнозом ХСН ежегодно выписываются более 600 000 пациентов, преимущественно 65 лет и старше, а вероятность повторной госпитализации составляет около 25% в течение 30 дней после выписки из стационара и около 70% через год [4]. Частоту повторных госпитализаций и смертности повышают такие факторы, как низкая приверженность к терапии, игнорирование необходимости амбулаторных визитов и затруднения в распознавании пациентами ранних симптомов прогрессирования сердечной недостаточности, что часто наблюдается при наличии когнитивных нарушений [5]. Сочетание ХСН и когнитивной дисфункции из-за высокой распространенности среди пожилых людей в последнее время привлекает все большее внимание специалистов [6].…”

Section: Introductionunclassified

Cognitive impairment in chronic heart failure. How new therapeutic options for the treatment of chronic heart failure affect cognitive function?

Aksenova,

Osmolovskaya,

Petrukhina

et al. 2024

Evrazijskij kardiologičeskij žurnal

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Heart failure is a serious chronic illness and a global healthcare problem. Patients with heart failure have increased hospital readmission rates and mortality around the world. Heart failure often coexists with comorbidities of which cognitive impairment is particularly important. Сognitive impairment is present in around 30% to 80% in heart failure decreases quality of life and increases the frequency of repeated hospitalizations, increases mortality and worsens the prognosis in such patients. Despite existing research, the underlying pathophysiology of the relationship between heart failure and cognitive impairment remains poorly understood. The article discusses the best available evidence concerning different pathophysiological mechanisms behind cognitive impairment in individuals with heart failure. Heart failure and cognitive impairment have a number of common pathophysiological pathways including reduced cerebral blood flow, inflammation, neurohumoral activations, oxidative stress and changes in serum biomarkers or proteins. Understanding the pathophysiology of diseases will allow the effective evaluation of health status and development of suitable treatments. Prompt detection of cognitive impairment will bring about better clinical outcomes in heart failure patients. This review raises questions about the relationship between heart failure and cognitive dysfunction, provides evidence on the impact of new therapeutic options for treating heart failure on cognitive function, and suggests potential future research directions. For example, implantation of an artificial left ventricle may improve cognitive function; however, there are studies on immediate improvement in cognitive function followed by gradual deterioration over time after implantation of an artificial left ventricle, which requires long-term study In addition, evidence is provided for the effectiveness of using a relaxation scenario in virtual reality technology to reduce anxiety and affective complaints in somatic hospitalized patients, but the ability to improve cognitive function in patients with chronic heart failure remains to be explored.

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