Neuropsychological and sensory gating deficits related to remote 
alcohol abuse history in schizophrenia

Thoma, Robert J.; Hanlon, Faith M.; Miller, Gregory A.; Huang, Mingxiong; Weisend, Michael P.; Sánchez, Francisco; Waldorf, V. Ann; Jones, Aaron P.; Smith, Ashley K.; Formoso, Michael J.; Cañive, José M.

doi:10.1017/s1355617706060097

Cited by 26 publications

(31 citation statements)

References 57 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[5][6][7][8][9][10][11] Additionally, the association between P50 ratio and number of symptoms for conduct disorder, but not adult antisocial behavior, suggests a continuum of weaker P50 gating from AAB to ASPD depending on the severity of antisocial behavior in childhood.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study Revealing Impaired P50 Gating in Antisocial Personality Disorder

Lijffijt¹,

Moeller²,

Boutros³

et al. 2009

Journal of Neuropsychiatry

View full text Add to dashboard Cite

The authors investigated preattentive filtering assessed by P50 gating in nine participants with antisocial personality disorder (ASPD) and seven with adult-onset antisocial behavior (AAB). Relative to 15 comparison subjects, gating was impaired in ASPD, suggesting abnormal pre-attentive filtering in pathological impulsivity.Repetition-induced reduction in P50 amplitude (P50 gating) could reflect a preattentive mechanism that filters out irrelevant information, affecting cognitive and motor processes and task performance. 1,2 Strong evidence exists that P50 gating is impaired in psychosis-related disorders, such as schizophrenia, 3 and anxiety/stress-related disorders, such as posttraumatic stress disorder. 4 Although not addressed directly, recent findings also suggest weaker gating in disorders associated with pathological impulsivity, including alcohol abuse, 5-7 substance abuse, 5,8,9 adult attention-deficit hyperactivity disorder (ADHD), 10 bipolar disorder without psychosis, 11 and violence in schizophrenia, 1 even though in most of these studies results may be affected by overlap with psychosis-or anxiety-related disorders. Interestingly, Thoma et al. 7 showed that subjects with combined alcohol abuse disorder and schizophrenia had more severely impaired P50 gating than either disorder alone, suggesting partially independent mechanisms.Antisocial personality disorder (ASPD) is a disorder of pathological impulsivity without psychosis or anxiety. True ASPD, with childhood onset of antisocial behavior, differs in clinical characteristics from adolescent-or adult-onset antisocial behavior (AAB) by being associated with more pervasive sociodevelopmental, cognitive, and behavioral disturbances. 12 pilot study we investigated the relationship between P50 gating and pathological impulsivity directly in ASPD and AAB patients without past or current psychosis-or anxiety-related disorders. We expected impaired P50 gating in subjects with antisocial behavior relative to healthy comparison subjects. Methods ParticipantsAll subjects were recruited from the general population through advertisements. Participants completed the Structured Clinical Interview for DSM-IV axis I and axis II disorders (SCID-I and SCID-II). 13 Participants with antisocial behavior met criteria for ASPD or AAB. Healthy comparison subjects were required to have no current or past axis I or axis II disorders and to have no first-degree relatives with axis I or II disorders. Further criteria were age between 18 and 55 years old, hearing at least 60 dB, (corrected-to-) normal vision, no head trauma or epilepsy, and no current use of psychoactive medicine. Participants signed informed consent before participation. The study complied with the Declaration of Helsinki and was approved by the Committee for the Protection of Human Subjects institutional review board for the University of Texas Health Science Center at Houston.There were sixteen antisocial patients (mean age=34.50 years, SD=9.16) of whom three were female; the group included nin...

show abstract

Section: Discussionmentioning

confidence: 99%

A Pilot Study Revealing Impaired P50 Gating in Antisocial Personality Disorder

Lijffijt¹,

Moeller²,

Boutros³

et al. 2009

Journal of Neuropsychiatry

View full text Add to dashboard Cite

show abstract

“…The inability to suppress distracting, irrelevant information is proposed to contribute to the symptoms of schizophrenia Bramon et al, 2004). Associations with measures of neuropsychological impairment (Potter et al, 2006;Thoma et al, 2006;Thoma et al, 2003) support the interpretation of less efficient sensory gating in schizophrenia. Yet the reason for an exaggerated ratio in schizophrenia remains unclear, and the mechanisms leading to the suppression of the response to S2 are not yet identified.…”

Section: Introductionmentioning

confidence: 95%

Evoked and induced oscillatory activity contributes to abnormal auditory sensory gating in schizophrenia

et al. 2011

Self Cite

View full text Add to dashboard Cite

The ratio of magnetoencephalogram-recorded brain responses occurring 50ms after paired clicks (S2-evoked M50/S1-evoked M50) serves as a measure of sensory gating. An abnormally large ratio is commonly found in schizophrenia. Whether this abnormality indicates impaired gating is debated. Using event-related oscillations the present study sought to elucidate processes contributing to the phenomenon of altered M50 gating ratio. Schizophrenia inpatients (n=50) showed the expected large M50 gating ratio relative to 48 healthy controls, which correlated with less induced frontally generated activity in the 10-15Hz frequency band starting 200ms before the onset of S2. Patients also produced smaller alpha (8-12Hz) and gamma (60-80Hz) responses to S1. Results suggest that the deviant gating ratio in schizophrenia is a consequence of a complex alteration in the processing of incoming information that cannot be attributed to impaired gating alone.

show abstract

“…There were no differences in cognitive functioning among individuals with first-episode psychosis with and without AUD, SUD, or both. Thoma et al (2006) + AUD were more impaired on speed of processing, reasoning and problem solving, visual learning and memory, verbal learning and memory, and working memory than AUD. SZ + AUD also worse than SZ on speed of processing, reasoning and problem solving and visual learning and memory (visual reproduction immediate).…”

Section: Cognitive Deficitsmentioning

confidence: 85%

Cognitive Deficits in Schizophrenia and Alcoholism: A Review of the Evidence and Findings on the Effects of Treatment on Cognitive Functioning in Patients With Dual Diagnoses

Ralevski

Gianoli

et al. 2012

Journal of Dual Diagnosis

View full text Add to dashboard Cite

Objective: Although cognitive deficits have been carefully studied in both schizophrenia disorders and alcohol use disorders, comparatively little is known about cognitive deficits in patients with dual diagnoses of schizophrenia and alcohol use disorders. The main objectives of this article are (a) to review the literature on cognitive functioning in patients with dual diagnoses of schizophrenia and alcohol use disorders, and (b) to summarize the studies that have examined the effects of treatments on cognitive functioning in patients with these dual diagnoses. Methods: We identified and reviewed 10 studies that examined cognitive functioning in patients with schizophrenia and alcohol use disorders. We also identified and reviewed three studies that reported on treatments for cognitive deficits in patients with dual diagnoses of schizophrenia and alcohol use disorders. Results: Overall, patients with dual diagnoses of schizophrenia and alcohol use disorders were more cognitively impaired than those with a single diagnosis of schizophrenia or alcohol use disorders. The literature on the effects of treatment on cognitive functioning in patients with dual diagnoses is very limited, and the results indicate no effects of pharmacological treatments on cognitive functioning despite improvement in psychotic symptoms and/or abstinence from alcohol. Conclusions: There is a need for more systemic and rigorous study of cognitive deficits and their treatments in patients with dual diagnoses of schizophrenia and alcohol use disorders. (Journal of Dual Diagnosis, 8:205-217, 2012)

show abstract

Neuropsychological and sensory gating deficits related to remote alcohol abuse history in schizophrenia

Cited by 26 publications

References 57 publications

A Pilot Study Revealing Impaired P50 Gating in Antisocial Personality Disorder

A Pilot Study Revealing Impaired P50 Gating in Antisocial Personality Disorder

Evoked and induced oscillatory activity contributes to abnormal auditory sensory gating in schizophrenia

Cognitive Deficits in Schizophrenia and Alcoholism: A Review of the Evidence and Findings on the Effects of Treatment on Cognitive Functioning in Patients With Dual Diagnoses

Contact Info

Product

Resources

About