Neuropsychological and Neuroimaging Examinations of Self‐Reported Sleep Quality in Alcohol Use Disorder With and Without Korsakoff's Syndrome

Abstract

33Background: Alcohol Use Disorder (AUD) patients without Korsakoff's syndrome (KS) report a 34 variable self-rated sleep quality. Their ability to accurately judge their sleep quality may be related to 35 their alcohol-related cognitive deficits and brain damage. KS patients, who present severe brain 36 dysfunction, may be cognitively unable to judge their sleep quality. The aim of the present study is to 37 examine in AUD and KS patients, whether the absence of sleep complaint is associated with altered 38 brain structure and impaired cognitive abilities within specific cerebral networks. 39Methods: An assessment of subjective sleep quality was conducted in 20 healthy controls, 37 AUD 40 and 17 KS patients. Patients were first pooled together and then classified into two groups (no-41 complaint AUD+KS and complaint AUD+KS ) according to the total PSQI score. Cognitive scores, gray matter 42 volume (GM) and white matter (WM) integrity were compared between these two groups, and then in 43 AUD and KS patients separately. 44Results: Poor sleep quality was reported by 70% of AUD and 18% of KS patients. Compared to 45 controls, both no-complaint AUD+KS and complaint AUD+KS presented cortical and subcortical alterations as 46 well as episodic memory deficits, which were more severe in patients without sleep complaint. Only 47 no-complaint AUD+KS presented executive deficits. Then, considering the clinical diagnosis, GM volume 48 in fronto-temporal regions, WM integrity and executive functions were affected to the same extent in 49 AUD and KS without sleep complaint. 50 Conclusion:Our results confirm the high prevalence of sleep complaint in AUD patients and the rare 51 complaint in KS patients. In AUD and KS patients, the absence of sleep complaint may not indicate 52 good sleep quality but rather reflect executive deficits and fronto-thalamic damage. Alcohol-related 53 cognitive deficits may indeed alter the ability to self-evaluate sleep quality, suggesting that the use of 54 sleep questionnaire should be considered with caution in patients with executive deficits. 55

Alcohol consumption and sleep quality: a community-based study

“…Our findings are consistent with the literature, although previous studies were generally conducted among populations suffering from alcoholism or alcohol abuse (11,29,30) . A recent large-scale study, including 151 567 adults with problematic alcohol consumption and post-traumatic stress disorder symptoms, found an inverse association between alcohol consumption and sleep quality (11) .…”

“…A recent large-scale study, including 151 567 adults with problematic alcohol consumption and post-traumatic stress disorder symptoms, found an inverse association between alcohol consumption and sleep quality (11) . Another recent study, investigating the relationship between AUD, with and without Korsakoff's syndrome and sleep quality, showed that the sleep complaints were prevalent among the participants with AUD (29) . A longitudinal study with 696 adolescents (12-19 years old) found that insomnia and sleep problems may be a consistent problem for adolescents with AUD and may also be a risk factor for the development of AUD in adolescents (30) .…”

Determinants of health-related quality of life in recently detoxified patients with severe alcohol use disorder

“…In AUD, a few studies reported that poor sleep quality is related to poor QoL [ 42 ] or is an important component of HRQoL [ 56 ]. The absence of relationship between sleep quality and HRQoL in our study could be explained by the fact that recently detoxified sAUD patients with executive deficits could not be cognitively able to accurately self-evaluate their sleep [ 57 ]. Further investigations using objective sleep measures are required to better understand the relationship between sleep and HRQoL in AUD.…”

Determinants of Health-related Quality of Life in Recently Detoxified Patients With Severe Alcohol Use Disorder

“…In AUD, a few studies reported that poor sleep quality is related to poor QoL (42) or is an important component of HRQoL (56). The absence of relationship between sleep quality and HRQoL in our study could be explained by the fact that recently detoxi ed sAUD patients with executive de cits could not be cognitively able to accurately self-evaluate their sleep (57). Further investigations using objective sleep measures are required to better understand the relationship between sleep and HRQoL in AUD.…”