Neuropsychological and hypothalamic–pituitary-axis function in female patients with melancholic and non-melancholic depression

Michopoulos, Ioannis; Zervas, Iannis M.; Pantelis, C.; Tsaltas, Eleftheria; Papakosta, Veronica; Boufidou, Fotini; Nikolaou, Chrissoula; Papageorgiou, Charalabos; Soldatos, C. R.; Lykouras, Lefteris

doi:10.1007/s00406-007-0781-8

Cited by 55 publications

(39 citation statements)

References 59 publications

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“…Although depressed individuals perform worse in PAL and RVIP (Dahabra et al 1998;Michopoulos et al 2008;Porter et al 2003), depressed mood in the OCD patients is unlikely to have accounted for the above results. While the BDI-II scores in the OCD group were higher than controls, this was due in part to questions that might be equally endorsed in depression and OCD, such as items about guilt.…”

Section: Discussionmentioning

confidence: 54%

Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation

et al. 2010

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Section: Discussionmentioning

confidence: 54%

Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation

et al. 2010

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“…Pálsson et al 2000). The view that subtypes of depression with additional psychopathological symptoms are associated with poorer neuropsychological functioning, is also supported by research which demonstrates poorer neuropsychological functioning among MDD patients with the melancholic or psychotic sub-types of depression compared to patients with MDD without these sub-type specifiers (Fleming et al 2004;Michopoulos et al 2008;Schatzberg et al 2000). Withall et al (2010) found for patients with melancholic compared to patients with non-melancholic subtypes of MDD not only poorer performance but also a longer time for neuropsychological recovery.…”

Section: Subtypes Of Mood Disorders and Co-morbiditymentioning

confidence: 90%

Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors

2011

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Neuropsychological research in patients with affective disorders shows heterogeneous results with regard to the severity and profile of cognitive impairments. In this paper we hypothesize that the investigation of clinical (subtypes, comorbidity, traumatization, personality, severity, diurnal swings, course, duration, age of onset, biased processing, rumination, motivation, experience of failure, sleep, suicidal tendencies, computer attitudes), demographic (age, education, gender) and neurobiological factors (structural and functional brain changes, glucocorticoids, medication, ECT) that are related to cognitive performance has specified the understanding of severity and profile of neuropsychological impairments. We reviewed the literature pertaining to clinical, demographic and neurobiological factors following Pubmed and PsychInfo databases using different combinations of general key-terms including "Affective Disorder," "Depression," "Mania," "Neuropsychological," "Neurobiological," "Moderator," and "Review" as well as more specific demographic, clinical and neurobiological search terms. Findings from the literature show that the consideration of these factors has improved knowledge about the severity of neuropsychological impairments in patients with affective disorders whereas the neuropsychological profile is still poorly understood. Despite limited understanding, however, the existent results provide promising suggestions for the development of treatment programs.

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“…Assies and colleagues found no difference between the cortisol levels of depressed patients and controls and indicated that dehydroepiandrosteronesulphate may be a more important indicator of depression [Assies et al 2004]. Michopoulos and colleagues found that depressive patients had normal cortisol blood levels and there was no significant difference between melancholic and nonmelancholic depressive patients [Michopoulos et al 2008]. Glucocorticoids play a critical role in mediating stress-induced downregulation of BDNF in the hippocampus [Schmidt and Duman, 2007].…”

Section: Discussionmentioning

confidence: 99%

Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features

Kotan¹,

Sarandöl²,

Kırhan³

et al. 2012

Therapeutic Advances in Psychopharmacology

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Abstract:Objective: Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and leptin have been hypothesized to be involved in the neurobiology of depression. The aim of this study was to investigate BDNF, VEGF and leptin levels in patients with severe melancholic depression. Methods: A total of 40 drug-free patients with major depressive disorder (MDD) with melancholic features and 40 healthy controls were included in the study. Demographic information, psychiatric evaluation and physical examination were documented for both groups. Serum BDNF, VEGF levels were determined by enzyme-linked immunosorbent assay and leptin with radioimmunoassay methods. The Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were applied to the patients. Results: There were no significant differences in serum BDNF, VEGF and leptin levels between the patient and control groups. There was a negative correlation between BDNF levels and the number of depressive episodes. It was noted that VEGF levels decreased with increasing severity of depression. Conclusions: These findings suggest that BDNF levels might be associated with the recurrence of depression and VEGF levels might be a determinant of the severity of depression.

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Neuropsychological and hypothalamic–pituitary-axis function in female patients with melancholic and non-melancholic depression

Cited by 55 publications

References 59 publications

Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation

Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation

Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors

Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features

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