Neuropsychological and electrophysiological indices of neurocognitive dysfunction in bipolar II disorder

Andersson, Stein; Barder, Helene Eidsmo; Hellvin, Tone; Lövdahl, H.; Malt, Ulrik Fredrik

doi:10.1111/j.1399-5618.2008.00638.x

Cited by 76 publications

(79 citation statements)

References 54 publications

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“…However, the sample size of BD II patients in these two studies was relatively small. Noteworthy, also, is the study by Andersson et al (2008), where performance of BD II patients was significantly worse than that of HCs on all measures, except for phonemic verbal fluency. These authors discussed the functional significance of neuropsychological impairment and suggested that differences regarding some aspects of executive function may be related to psychomotor speed, and not primarily to dysexecutive functioning, taking into consideration their findings in electrophysiological index.…”

Section: Discussionmentioning

confidence: 97%

“…Three out of four studies found that BD II participants had a significantly poorer performance than the HC group Andersson et al 2008 ;Simonsen et al 2008). In one of them, both BD I and BD II groups did not differ significantly among each other (Simonsen et al 2008) and in another the BD II patients showed an intermediate level of performance between the BD I and control group .…”

Section: Inhibitory Controlmentioning

confidence: 99%

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Are bipolar II patients cognitively impaired? A systematic review

et al. 2011

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Background. There is evidence that bipolar disorder (BD) is associated with significant neurocognitive deficits and this occurs in individuals with BD type I (BD I) and with BD type II (BD II). Only a few studies have focused on cognitive impairment in BD II. The aim of this study was to describe the pattern of cognitive impairment in patients with BD II, in order to identify specific cognitive deficits that distinguish BD II from BD I patients as well as from healthy subjects.Method. We performed a systematic review of the literature of neuropsychological studies of BD II published between 1980 and July 2009. Fourteen articles fulfilled the inclusion criteria and were included in this review.Results. Main cognitive deficits found in BD II include working memory and some measures of executive functions (inhibitory control) and approximately half of the studies also detected verbal memory impairment.Conclusions. There are subtle differences between the two subtypes regarding cognition. This may suggest neurobiological differences between the two subgroups which will be helpful in order to determine cognitive endophenotypes in BD subtypes.

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Section: Discussionmentioning

confidence: 97%

Section: Inhibitory Controlmentioning

confidence: 99%

Are bipolar II patients cognitively impaired? A systematic review

et al. 2011

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“…The authors suggested that P300, but not MMN, was a valid endophenotype, albeit with limited specificity. In contrast, Andersson and colleagues 26 found that patients with bipolar II disorder had decreased frontal MMN in the absence of a P300 impairment (although they reported a delayed P3a for female patients). Given such contrasting findings and questions surrounding the specificity of MMN and P300 (and P3a), there is a need to further explore these biomarkers in patients with bipolar disorder.…”

Section: Introductionmentioning

confidence: 85%

Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster

Kaur

Battisti

Lagopoulos

et al. 2012

J Psychiatry Neurosci

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IntroductionA current topic of controversy in psychiatry is whether or not bipolar-spectrum disorders should be considered as part of the psychosis cluster in the upcoming DSM-V. Currently, bipolarspectrum disorders are classified as mood disorders in line with the Kraeplinian dichotomy; however, recent literature suggests that there may be more overlap in the underlying neurobiology in these major psychiatric illnesses than once thought.1 It is not unusual for patients with similar pheno typic presentation and common symptomatology to receive a diagnosis of either a bipolar-spectrum or a schizophrenia-spectrum disorder, particularly in the early stages of illness. Thus, investigation of the underlying neurobiology of these 2 major psychi atric groups is crucial to our understanding of their pathophysiological overlap. Shared genetic vulnerabilities in individuals with bipolar disorder and schizophrenia have been documented and describe how some symptoms overlap and how some are unique. [2][3][4][5] In support of the shared genetic basis of these disorders, there is evidence that first-degree relatives of probands with bipolar disorder or schizophrenia are at increased risk for either disorder, irrespective of the phenotype present in their relative. Background: Mismatch negativity (MMN) and P3a are event-related potentials that index deviance detection and the orienting response, respectively. We have previously shown that the MMN/P3a complex is impaired in patients with schizophrenia and affective spectrum psychoses, which suggests that it may index a common pathophysiology and argues against the purported specificity in schizo phrenia. Further research is warranted to determine whether patients with bipolar-spectrum disorders show similar impairments in these biomarkers. Methods: We assessed patients aged 15-30 years with early schizophrenia-spectrum disorders (schizophrenia, schizoaffective disorder, schizophreniform disorder), early bipolar-spectrum disorders (bipolar I or II, with and without psychotic features) and healthy, matched controls. We acquired MMN/P3a amplitudes during a 2-tone, auditory paradigm with 8% duration deviants. Clinical, psychosocial and neuro psychological assessments were also undertaken. Results: We included 20 patients with schizophrenia-spectrum disorders, 20 with bipolar-spectrum disorders and 20 controls in our study. Both patient groups showed significantly reduced frontocentral MMN and central P3a amplitudes. The schizophrenia-spectrum group had additional impairments in left temporal MMN and frontal P3a. Both patient groups performed worse than controls across psychosocial and clinical measures; however, only the schizophrenia-spectrum group performed significantly worse than controls for cognitive measures. Correlational analyses between patient groups revealed associations between frontocentral or left temporal MMN and psychiatric symptomatology or quality of life measures. Limitations: Limitations to our study include the modest sample size and the lack of control with r...

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“…The neural mechanisms underlying disturbances in cognitive functions are poorly understood, and they may be present even at the level of automatic information processing (for a review, see Beck, 2008). Therefore several studies used aMMN (or its magnetic counterpart, MMNm) to study automatic sensorycognitive processes in depression (Iv, Zhao, Gong, Chen, & Miao, 2010;K€ ahk€ onen et al, 2007;Lepist€ o et al, 2004;Pang et al, 2014;Takei et al, 2009) and BP (Andersson, Barder, Hellvin, Løvdahl, & Malt, 2008;Takei et al, 2010). Takei et al applied magnetoencephalography to measure information processing deficit in depression (2009) andBP (2010).…”

Section: Mood Disordersmentioning

confidence: 99%

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Kremláček

Kreegipuu

Tales

et al. 2016

Cortex

113

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The visual mismatch negativity (vMMN) response is an event-related potential (ERP) component, which is automatically elicited by events that violate predictions based on prior events. VMMN experiments use visual stimulus repetition to induce predictions, and vMMN is obtained by subtracting the response to rare unpredicted stimuli from those to frequent stimuli. One increasingly popular interpretation of the mismatch response postulates that vMMN, similar to its auditory counterpart (aMMN), represents a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals. Here we discuss the physiological and theoretical basis of vMMN and review thirty-three studies from the emerging field of its clinical applications, presenting a meta-analysis of findings in schizophrenia, mood disorders, substance abuse, neurodegenerative disorders, developmental disorders, deafness, panic disorder and hypertension. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensory modality and thus of vital importance in environmental information processing and response, and a modality which arguably may be more sensitive to some pathological changes. However, due to the relative infancy of research in vMMN compared to aMMN in clinical populations its potential for clinical application is not yet fully appreciated. The aim of this review and meta-analysis therefore is to present, in a detailed systematic manner, the findings from clinically-based vMMN studies, to discuss their potential impact and application, to raise awareness of this measure and to improve our understanding of disease upon fundamental aspects of visual information processing. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensor...

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Neuropsychological and electrophysiological indices of neurocognitive dysfunction in bipolar II disorder

Cited by 76 publications

References 54 publications

Are bipolar II patients cognitively impaired? A systematic review

Are bipolar II patients cognitively impaired? A systematic review

Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

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