Neuropsychologic Impairment in Early HIV Infection

Albert, Steven M.; Marder, Karen; Dooneief, George; Bell, Karen L.; Sano, Mary; Todak, George; Stern, Yaakov

doi:10.1001/archneur.1995.00540290115027

Cited by 102 publications

(53 citation statements)

References 15 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study supports and extends previous reports regarding the everyday life significance of NP impairments associated with HIV infection (Albert et al, 1995;Heaton et al, 1996;Hinkin et al, 2002;Marcotte et al, 1999;Stern et al, 1991). It is the largest such study to date and the most comprehensive in its coverage of both performance-based measures of IADLs and manifest measures of daily functioning outside of the laboratory.…”

Section: Discussionsupporting

confidence: 89%

“…At present, the few available studies concerning functional impact of HIV-related NP deficits suggest that these deficits are associated with impaired driving ability, worse performance on standardized work samples, increased unemployment and complaints of problems in vocational functioning and everyday living (Albert et al, 1995;Benedict et al, 2000;Heaton et al, 1996;Mapou et al, 1993;Marcotte et al, 1999;Stern et al, 1991). Of particular importance to HIV1 patients is the ability to effectively manage their antiretroviral medications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of HIV-associated neuropsychological impairment on everyday functioning

Heaton

Marcotte

Mindt

et al. 2004

J. Inter. Neuropsych. Soc.

677

689

View full text Add to dashboard Cite

HIV-1 infection can be associated with neuropsychological (NP) deficits ranging from subtle to severe. The purpose of this study was to evaluate the functional, or "real-world" impact of HIV-associated NP impairment in a group of 267 HIV-infected participants. All participants received comprehensive NP, neuromedical, and standardized functional evaluations that included laboratory measures of shopping, cooking, financial management, medication management and vocational abilities. Compared to NP-normal participants, those with NP impairment performed significantly worse on all laboratory measures of everyday functioning. Multivariate analyses revealed that the NP ability domains of Abstraction0Executive Function, Learning, Attention0Working Memory and Verbal abilities most strongly and consistently predicted failures on the functional battery. Both NP impairment and impairment on the functional battery were significantly associated with subjective experiences of cognitive difficulties, as well as unemployment and increased dependence in activities of daily living; multivariate prediction models that also considered depressed mood and biological measures of disease progression revealed that impairment on the functional battery and depression were the only unique predictors of all three indicators of "real-world" functioning. The current results add to growing evidence concerning the clinical significance of HIV-associated NP impairment. Objective, laboratory based functional measures, such as those used here, may compliment NP testing in future studies directed at understanding the impact on life quality of central nervous system disorders and their treatments. Finally, there is a need for additional research investigating the apparently independent effect of depression on level of everyday functioning in HIV infected persons. (JINS, 2004, 10, 317-331.)

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

The impact of HIV-associated neuropsychological impairment on everyday functioning

Heaton

Marcotte

Mindt

et al. 2004

J. Inter. Neuropsych. Soc.

677

689

View full text Add to dashboard Cite

show abstract

“…Consistent with U.S. findings on the impact of HIV-associated neurocognitive impairment on instrumental activities of daily living (Heaton et al, 2004a) and employment (Albert et al, 1995;Heaton et al, 1994), we found, in the Chinese HIV+ group, a correlation between NP functioning and complaints of cognitive difficulties in everyday life (i.e., PAOFI), and also a modest association between unemployment status and overall level of NP performance. However, given the major cultural and lifestyle differences in these two countries, much more research is needed to understand the functional consequences of general and specific neurocognitive deficits in China.…”

Section: Discussionsupporting

confidence: 88%

Neurobehavioral effects of HIV-1 infection in China and the United States: A pilot study

Cysique

Jin

Franklin

et al. 2007

J. Inter. Neuropsych. Soc.

View full text Add to dashboard Cite

The HIV epidemic in China has been increasing exponentially, yet there have been no studies of the neurobehavioral effects of HIV infection in that country. Most neuroAIDS research has been conducted in Western countries using Western neuropsychological (NP) methods, and it is unclear whether these testing methods are appropriate for use in China. Twenty-eight HIV seropositive (HIV+) and twenty-three HIV seronegative (HIV−) individuals with comparable gender, age, and education distributions were recruited in Beijing and the rural Anhui province in China. Thirtynine HIV+ and thirty-one HIV− individuals were selected from a larger U.S. cohort recruited at the HIV Neurobehavioral Research Center, in San Diego, to be matched to the Chinese sample for age, disease status, and treatment variables. The NP test battery used with the U.S. and China cohorts included instruments widely used to study HIV infection in the United States. It consisted of 14 individual test measures, each assigned to one of seven ability areas thought to be especially vulnerable to effects of HIV on the brain (i.e., verbal fluency, abstraction/executive function, speed of information processing, working memory, learning, delayed recall, and motor function). To explore the cross-cultural equivalence and validity of the NP measures, we compared our Chinese and U.S. samples on the individual tests, as well as mean scaled scores for the total battery and seven ability domains. On each NP test measure, the mean of the Chinese HIV+ group was worse than that of the HIV−group. A series of 2 × 2 analyses of variance involving HIV+ and HIV− groups from both countries revealed highly significant HIV effects on the Global and all Domain mean scaled scores. Country effects appeared on two of the individual ability areas, at least partly due to education differences between the two countries. Importantly, the absence of HIV-by-Country interactions suggests that the NP effects of HIV are similar in the two countries. The NP test battery that was chosen and adapted for use in this study of HIV in China appears to have good cross-cultural equivalence, but appropriate Chinese norms will be needed to identify disease-related impairment in individual Chinese people. To inform the development of such norms, a much larger study of demographic effects will be needed, especially considering the wide range of education in that country.

show abstract

“…‘These individuals can have some slowness in their thinking, memory problems, and decreased problem-solving ability in the face of complex or novel tasks’ [7]. A rapidly expanding literature supports that neuropsychological deficits are chronic in early HIV infection and lead to work disability [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Growth Hormone, Fatigue, Poor Sleep, and Disability in HIV Infection

Darko

Mitler²,

Miller³

1998

Neuroendocrinology

View full text Add to dashboard Cite

Poor sleep, daytime fatigue, and loss of cognitive ability exist during all stages of HIV infection, worsening with disease progression. These symptoms contribute to disability and poor quality of life. Data from several research groups support a role of somnogenic inflammatory process peptides elevated in HIV infection, e.g. TNFα. Though the literature is in conflict regarding an effect of HIV infection on growth hormone (GH) secretion, GH axis dysregulation and treatment with GH may be important in HIV infection, e.g. in the wasting syndrome. It has long been known that GH varies with changes in sleep. The hypothesis tested in the current study was that the relationship between delta frequency (0.5–4.0 Hz) sleep EEG amplitude (square root of power from frequency analysis) and GH secretion would differ between HIV positive (HIV+) and HIV negative (HIV–) subjects. In 14 subjects (6 HIV+ and 8 HIV–, none with current or past AIDS-defining illness) a linear relationship change across the night’s sleep was found in the coupling between delta frequency sleep EEG amplitude and GH secretion. The phase coupling change was in opposite directions in HIV+ versus HIV– subjects. This difference supports the hypothesis that the brain-based coordination of sleep and sleep-related physiology deteriorates early in HIV infection, and that GH dysregulation may contribute to this sleep pathology.

show abstract

Neuropsychologic Impairment in Early HIV Infection

Cited by 102 publications

References 15 publications

The impact of HIV-associated neuropsychological impairment on everyday functioning

The impact of HIV-associated neuropsychological impairment on everyday functioning

Neurobehavioral effects of HIV-1 infection in China and the United States: A pilot study

Growth Hormone, Fatigue, Poor Sleep, and Disability in HIV Infection

Contact Info

Product

Resources

About