Neuropsychiatric Systemic Lupus Erythematosus

Souirti, Zouhayr; Lahlou, Mariam; Ouali, Ourda El; Chtaou, Naïma; Aarab, Chadya; Ghazouani, Fatima El; Bono, W.; Rammouz, Ismaïl; Belahsen, Faouzi; Messouak, Ouafae

doi:10.4236/ojra.2013.32013

Cited by 6 publications

(9 citation statements)

References 19 publications

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“…Systemic lupus erythematosus (SLE) is a chronic autoimmune multifactorial disease characterized by multisystemic involvement and diverse clinical features [104]. Involvement of the nervous system with cognitive and/or psychiatric, central, and peripheral nervous is referred to as neurolupus [105] and has been reported to be associated with brain calcification up to 30% of patients [106].…”

Section: Classificationmentioning

confidence: 99%

Basal ganglia calcifications (Fahr’s syndrome): related conditions and clinical features

et al. 2019

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Basal ganglia calcifications could be incidental findings up to 20% of asymptomatic patients undergoing CT or MRI scan. The presence of neuropsychiatric symptoms associated with bilateral basal ganglia calcifications (which could occur in other peculiar brain structures, such as dentate nuclei) identifies a clinical picture defined as Fahr's Disease. This denomination mainly refers to idiopathic forms in which no metabolic or other underlying causes are identified. Recently, mutations in four different genes (SLC20A2, PDGFRB, PDGFB, and XPR1) were identified, together with novel mutations in the Myogenic Regulating Glycosylase gene, causing the occurrence of movement disorders, cognitive decline, and psychiatric symptoms. On the other hand, secondary forms, also identified as Fahr's syndrome, have been associated with different conditions: endocrine abnormalities of PTH, such as hypoparathyroidism, other genetically determined conditions, brain infections, or toxic exposure. The underlying pathophysiology seems to be related to an abnormal calcium/phosphorus homeostasis and transportation and alteration of the blood-brain barrier.

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Section: Classificationmentioning

confidence: 99%

Basal ganglia calcifications (Fahr’s syndrome): related conditions and clinical features

et al. 2019

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“…It is interesting to note that imaging studies in neuropsychiatric SLE have shown cerebral atrophy, ventricular dilatation, cerebral edema, and cerebral infarction as well as intracranial hemorrhage. 9 Hence, the prominent ventricular system could be indicative of an impending neuropsychiatric involvement.…”

Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematosus presenting as erythema annulare centrifugum

Chander

Yadav

Singh

et al. 2014

Lupus

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“…Table (4). Focal fits were the commonest type of seizure representing 50% followed by generalized tonicclonic 33% and focal with secondary generalization 17% Table (5). There was an association between seizures and disease duration, diabetes mellitus, headache, cognitive impairment, cerebrovascular and MRI findings with significant predictor risk factor affecting seizures Table (6).…”

Section: 70%mentioning

confidence: 99%

“…Headache is rather a common complaint that can be associated with the disease. Most common types of headache are migraine with or without aura, tension headache and idiopathic intracranial hypertension [5] .…”

Section: Introductionmentioning

confidence: 99%

Neurological Study of Patients with Systemic Lupus Erythematosus

Shahba

Eldin

2019

The Medical Journal of Cairo University

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Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology affecting multiple organ systems including the joints, skin, heart, lungs, kidneys and the nervous system. Aim of Work: Is to study the neurological manifestations in patients with systemic lupus erythematosus attending Tanta University Hospitals over 6 months. Patients and Methods: Cross sectional study was carried out on 60 patients with SLE diagnosed according to American College of Rheumatology criteria attending Tanta University Hospitals during six months. Results : Mean age was 46.7± 12.1. Fifty two patients were females and 8 patients were males. This study found that 43 patients showed neurological manifestations, headache was the most common representing 51.7% followed by cognitive impairment 46.7% and cerebrovascular stroke 13%. 6 patients complicated by seizures in whom 3 patients were focal. Focal slowing was the most common EEG abnormalities while white matter hyper intensity lesions were the most common MRI brain abnormalities. Conclusion: Neurological manifestations are frequent in SLE patients. Headache is the most common neurological manifestation followed by cognitive impairment.

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Neuropsychiatric Systemic Lupus Erythematosus

Cited by 6 publications

References 19 publications

Basal ganglia calcifications (Fahr’s syndrome): related conditions and clinical features

Basal ganglia calcifications (Fahr’s syndrome): related conditions and clinical features

Systemic lupus erythematosus presenting as erythema annulare centrifugum

Neurological Study of Patients with Systemic Lupus Erythematosus

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