Neuropsychiatric symptoms are associated with disability in cognitively impaired Latino elderly with and without dementia: results from the Sacramento Area Latino study on Aging

Hinton, W Ladson; Farias, Sarah E Tomaszewski; Wegelin, Jacob A.

doi:10.1002/gps.1952

Cited by 34 publications

(19 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings on VaD partly confirmed results from a previous study in which anxiety, depression, and psychosis have been shown to steadily increase with disease progression [22]. In a study that examined the relationship between NPS burden and disability in cognitively impaired older Latinos, NPS were associated with increased disability in patients with cognitive impairment [66]. In the present study, many NPS were related to disability in both groups of patients (AD and VaD) considering the ADL items, i.e.…”

Section: Direct Indirect and Total Effect Estimates Of Neuropsychiatsupporting

confidence: 92%

Neuropsychiatric Symptoms and Functional Status in Alzheimer’s Disease and Vascular Dementia Patients

D’Onofrio¹,

Sancarlo²,

Panza³

et al. 2012

CAR

View full text Add to dashboard Cite

Neuropsychiatric symptoms (NPS) are increasingly recognized as common in patients with dementia, both of degenerative (Alzheimer's disease, AD) or vascular origin (vascular dementia, VaD). In this study, 302 demented patients, 166 with AD and 136 with VaD, were evaluated for NPS according to the Neuropsychiatric Inventory (NPI) score at the Alzheimer's Evaluation Unit of Casa Sollievo della Sofferenza Hospital-IRCCS, San Giovanni Rotondo, Italy. A comprehensive geriatric assessment was also performed in all demented patients. The means of NPI scores did not differ in two groups. The overall prevalence of NPS was similar in both groups of patients (69.7% vs. 69.4%). Patients with AD had higher frequency in agitation/aggression and irritability/lability than VaD patients. Logistic analysis demonstrated a significant association between severity of the cognitive impairment and depression and eating disorders in both AD and VaD patients. The association with agitation/aggression, irritability/lability, and aberrant motor activity was found in AD only, and with apathy in VaD patients only. In both AD and VaD patients, there was a significant association between the impairment in activities of daily living (ADL) and the majority of NPI domains. A significant association was also found between the impairment of the instrumental activities of daily living (IADL) and agitation/aggression, anxiety, aberrant motor activity in AD and depression, apathy, irritability/lability, sleep disturbance and eating disorders in both AD and VaD patients. In particular, a causal mediation analysis was performed to better understand whether the relationship of NPS to functional impairment was direct or mediated by severity of cognitive dysfunction, i.e., Clinical dementia rating scale (CDR) score. Only agitation/aggression was mediated by the CDR score in affecting ADL status in VaD patients (OR: 1.12, 95% CI: 1.01-1.27). The NPI-Distress scores showed a significantly higher levels of distress in caregivers of AD than VaD. There were significant differences between AD and VaD patients with NPS, and these symptoms varied according to dementia subtype and severity and induced marked disability in ADL and IADL, increasing, prevalently, the distress of the caregivers of AD patients.

show abstract

Section: Direct Indirect and Total Effect Estimates Of Neuropsychiatsupporting

confidence: 92%

Neuropsychiatric Symptoms and Functional Status in Alzheimer’s Disease and Vascular Dementia Patients

D’Onofrio¹,

Sancarlo²,

Panza³

et al. 2012

CAR

View full text Add to dashboard Cite

show abstract

“…However, the unique contribution of these factors to everyday function when considering them simultaneously has not been well studied. Depressive symptoms and apathy are two of the most common neuropsychiatric disturbances in older adult populations, and both can be present throughout the cognitive spectrum ranging from normal cognitive aging through MCI and dementia (e.g., Apostolova & Cummings, 2008; Ellison et al, 2008; Hinton et al, 2008; Okura et al, 2010; Starkstein et al, 2005; Tam et al, 2008; Van Winkel et al, 2006). A primary finding of the present study was that cognitive performance, as well as ratings of depressive symptoms and apathy, all make largely independent contributions to informant-based ratings of functional capacities in older adults.…”

Section: Discussionmentioning

confidence: 99%

“…To this end, the contribution of a variety of neuropsychiatric symptoms to functional impairment also has been examined. Two of the neuropsychiatric symptoms most consistently associated with everyday functional abilities are depression and apathy (D’Onofrio et al, 2012; Hinton, Tomaszewski Farias, & Wegelin, 2008; Okura et al, 2010; Palmer et al, 2011; Tam et al, 2008). …”

mentioning

confidence: 99%

The Independent Contributions of Cognitive Impairment and Neuropsychiatric Symptoms to Everyday Function in Older Adults

Rog

Park

Harvey

et al. 2014

The Clinical Neuropsychologist

View full text Add to dashboard Cite

The everyday functional capacities of older adults are determined by multiple factors. The primary goal of the present study was to evaluate whether apathy and depression have unique influences on degree of functional impairment, independent of the effects of specific cognitive impairments. Participants included 344 older adults (199 normals, 87 with MCI, 58 with dementia). The Everyday Cognition (ECog) scales were used to measure both global and domain-specific functional abilities. Neuropsychiatric symptoms of depression and apathy were measured by the Neuropsychiatric Inventory (NPI), and specific neuropsychological domains measured included episodic memory and executive functioning. Results indicated that worse memory and executive function, as well as greater depression and apathy, were all independent and additive determinants of poorer functional abilities. Apathy had a slightly more restricted effect than the other variables across the specific functional domains assessed. Secondary analysis suggested that neuropsychiatric symptoms may be more strongly associated with everyday function within cognitively normal and MCI groups, while cognitive impairment is more strongly associated with everyday function in dementia. Thus, a somewhat different set of factors may be associated with functional status across various clinical groups.

show abstract

“…The fact that in the REAL cohort the MMSE range was wide (10-26 at inclusion) permitted us to perform the present study, because several studies underline a marked link between cognitive impairment and functional decline in AD patients [20][21][22] . The finding of a pattern of loss of ADL depends on the score for each activity, according to the scale used.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Loss of Basic Activities of Daily Living in Alzheimer Patients: A Cross-Sectional Study of the French REAL Cohort

Lechowski

Pradelles²,

Crane³

et al. 2010

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background/Aims: To characterize loss of basic activities of daily living (BADL) in 687 Alzheimer’s disease (AD) community-dwelling patients included in the French REAL cohort. Methods: Patients had mild to moderately severe AD, and the mean age was 77.8 years. Patterns of loss of the 6 BADL were described at inclusion using the Lawton scale. Results: With 6 binary BADL scores, each patient presented at inclusion a set of losses. For 53% of women, the sets of losses were included within each other or were identical, adding losses in physical ambulation, grooming, bathing, dressing, toilet and feeding, respectively. For 47% of men, a similar sequence was identified, with loss of dressing occurring secondly. A global cohesion of sets of losses was found for 87% of women and 86% of men. The Lawton scale is very useful for the assessment of AD patients.

show abstract

Neuropsychiatric symptoms are associated with disability in cognitively impaired Latino elderly with and without dementia: results from the Sacramento Area Latino study on Aging

Cited by 34 publications

References 32 publications

Neuropsychiatric Symptoms and Functional Status in Alzheimer’s Disease and Vascular Dementia Patients

Neuropsychiatric Symptoms and Functional Status in Alzheimer’s Disease and Vascular Dementia Patients

The Independent Contributions of Cognitive Impairment and Neuropsychiatric Symptoms to Everyday Function in Older Adults

Patterns of Loss of Basic Activities of Daily Living in Alzheimer Patients: A Cross-Sectional Study of the French REAL Cohort

Contact Info

Product

Resources

About