Neuropsychiatric symptoms among adult patients with aseptic meningitis: a prospective case series

Damsgaard, Jesper; Andersen, Henning; Hjerrild, Simon; Marinovskij, Edvard; Deutch, Susanna; Schembri, Adrian; Tarp, Britta; Kristensen, Lise; Lindberg, Jens; Erlandsen, Mogens; Leutscher, Peter

doi:10.1111/acps.12539

Cited by 5 publications

(2 citation statements)

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“…The inclusion of comprehensive tools for mental status and cognition revealed that AM patients might present with subtle visual memory and cognitive processing speed impairment [ 24 ], and worse global mental health status, compared to healthy controls. [ 101 , 102 ].…”

Section: Methodsmentioning

confidence: 99%

Cognitive decline following acute viral infections: literature review and projections for post-COVID-19

Damiano

Guedes

Rocca

et al. 2021

Eur Arch Psychiatry Clin Neurosci

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Recently, much attention has been drawn to the importance of the impact of infectious disease on human cognition. Several theories have been proposed, to explain the cognitive decline following an infection as well as to understand better the pathogenesis of human dementia, especially Alzheimer’s disease. This article aims to review the state of the art regarding the knowledge about the impact of acute viral infections on human cognition, laying a foundation to explore the possible cognitive decline followed coronavirus disease 2019 (COVID-19). To reach this goal, we conducted a narrative review systematizing six acute viral infections as well as the current knowledge about COVID-19 and its impact on human cognition. Recent findings suggest probable short- and long-term COVID-19 impacts in cognition, even in asymptomatic individuals, which could be accounted for by direct and indirect pathways to brain dysfunction. Understanding this scenario might help clinicians and health leaders to deal better with a wave of neuropsychiatric issues that may arise following COVID-19 pandemic as well as with other acute viral infections, to alleviate the cognitive sequelae of these infections around the world.

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Section: Methodsmentioning

confidence: 99%

Cognitive decline following acute viral infections: literature review and projections for post-COVID-19

Damiano

Guedes

Rocca

et al. 2021

Eur Arch Psychiatry Clin Neurosci

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“…These ndings align with our research, where we observed that acute disturbed smell and taste were not reliable predictors of CNS-related long-COVID at follow-up.Recently, suggestions of a common pathogenesis in patients with other post-viral conditions have emerged, where potential pathogenic mechanisms, including those previously discussed such as neuroin ammation and direct viral brain damage, may overlap (Choutka et al, 2022). Although post-viral conditions have also been described among mild cases(Damsgaard et al, 2016), the risk of experiencing post-acute symptoms after infections with SARS-CoV-2 and other pathogens is associated with the severity of the initial infection(Choutka et al, 2022; Davis et al, 2023b;Maglietta et al, 2022) as well as being a young adult(Ørum et al, 2021). These ndings may hold a signi cant role for understanding and addressing the diverse range of symptoms observed among long COVID patients.Collectively, our ndings, along with existing literature, hint at the possibility that both neuroinvasion and local in ammation may be initiated during the acute phase of COVID-19, potentially establishing a link between acute symptoms and persistent COVID-19 manifestations.…”

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confidence: 99%

Headache or Disturbed Smell and Taste During Acute COVID-19 as Predictors of Long COVID at One Year

Agergaard

2024

Preprint

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Purpose: Long coronavirus disease (COVID) poses a significant health concern for a substantial proportion of COVID-19 patients. Viral pathogenesis studies suggest the potential of central nervous system (CNS) affection in the acute phase of COVID-19 predicting long COVID. This study investigates whether acute COVID-19 symptoms, particularly headache and disturbed smell and taste, predict manifestations of long COVID. Methods: This prospective cohort study included COVID-19 patients hospitalized between March 2020, and May 2021. One year after discharge, patients responded to a symptom questionnaire. Logistic regression analysis was used to determine the odds ratio (OR) for these outcomes. Results: Of 288 eligible patients, 111 responded to the follow-up questionnaire. At 1 year follow-up, disturbed smell and taste during acute COVID-19 did not elevate the risk of long COVID. However, patients with acute headache demonstrated a tendency towards an elevated risk of CNS-related long COVID. Notably, this risk significantly increased in patients reporting dizziness (adjusted OR=4.20; 95% confidence interval (CI) 1.19 - 14.85). Neither disturbed smell and taste nor headache during acute COVID-19 indicated a statistically significant risk of worsening in fatigue, health, or total symptom score at 1-year follow-up. Conclusion: Headache, and not disturbed smell and taste, predicted CNS-related long COVID. Further research is warranted to clarify pathways connecting CNS-related symptoms during acute COVID-19 with long COVID, aiding the efforts of addressing the range of symptoms observed among long COVID patients and developing effective interventions.

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Ascertaining Whether Suicides Are Caused by Infections

Brundin

Grit

2016

JAMA Psychiatry

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Neuropsychiatric symptoms among adult patients with aseptic meningitis: a prospective case series

Cited by 5 publications

References 5 publications

Cognitive decline following acute viral infections: literature review and projections for post-COVID-19

Cognitive decline following acute viral infections: literature review and projections for post-COVID-19

Headache or Disturbed Smell and Taste During Acute COVID-19 as Predictors of Long COVID at One Year

Ascertaining Whether Suicides Are Caused by Infections

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