Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

Lanctôt, Krista L.; Amatniek, Joan; Ancoli‐Israel, Sonia; Arnold, Steven E.; Ballard, Clive; Cohen‐Mansfield, Jiska; Ismail, Zahinoor; Lyketsos, Constantine G.; Miller, David S.; Musiek, Erik S.; Osorio, Ricardo S.; Rosenberg, Paul B.; Satlin, Andrew; Steffens, David C.; Tariot, Pierre N.; Bain, Lisa J.; Carrillo, María C.; Hendrix, James A.; Jurgens, Heidi A.; Boot, Brendon

doi:10.1016/j.trci.2017.07.001

Cited by 260 publications

(184 citation statements)

References 119 publications

(126 reference statements)

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“…Metabolites with low SNR due to lower concentrations and metabolites with signals that overlap with those of other metabolites had slightly higher mean CVs and RDs. These reproducibility data provide the foundation for utilizing MRS at 7 T to study the ACC and PCC, two regions that play a major role in the affective and cognitive symptoms of AD, 26,28,29 in intervention or longitudinal studies. To date, there have been four other reproducibility studies at 7 T in younger healthy adults.…”

Section: Discussionmentioning

confidence: 91%

Reproducibility of brain MRS in older healthy adults at 7T

et al. 2018

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To date, the majority of MRS reproducibility studies have been conducted in healthy younger adults, with only a few conducted in older adults at 3 T. With the growing interest in applying MRS methods to study the longitudinal course and effects of treatments in neurodegenerative disease, it is important to establish reproducibility in age‐matched controls, especially in older individuals. In this study, spectroscopic data were acquired using a stimulated echo acquisition mode (STEAM) localization technique in two regions (anterior and posterior cingulate cortices—ACC, PCC, respectively) in 10 healthy, cognitively normal older adults (64 ± 8.1 years). Reproducibility was assessed via mean coefficients of variation (CVs) and relative differences (RDs) calculated across two visits performed 2–3 months apart. Metabolites with high signal‐to‐noise ratio (SNR) such as NAA, tCho, and Glu had mean CVs of 10% or less and mean RDs of 15% or less across both regions. Metabolites with lower SNR such as GABA and Gln had slightly higher mean CVs of 22% or less and mean RDs of 27% or less across both regions. These results demonstrate the feasibility of acquiring MRS data at 7 T in older subjects, and establish that the spectroscopic data are reproducible in both the ACC and PCC in older, healthy subjects to the same extent as in previous studies in young subjects.

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Section: Discussionmentioning

confidence: 91%

Reproducibility of brain MRS in older healthy adults at 7T

et al. 2018

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“…The prevalence of antidepressant use was reported up to 38% among patients with ALS [26]. In patients of Alzheimer’ disease, depression is found to be an omnibus prevalence of 32% (16% in population-based Alzheimer’ disease studies, and 44.3% in hospital-based studies) [27]. …”

Section: Discussionmentioning

confidence: 99%

Bidirectional Connections between Depression and Ataxia Severity in Spinocerebellar Ataxia Type 3 Patients

et al. 2018

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Background: Spinocerebellar ataxia type 3 (SCA3), which is the most common subtype of SCA worldwide, exhibits common neuropsychological symptoms such as depression. However, the contribution of depression to the severity of SCA3 has not yet been thoroughly investigated. Methods: The present study investigated the prevalence of depression using Beck depression inventory in 104 molecularly conﬁrmed SCA3 patients from China. The putative risk factors for depression and whether the depression could affect the severity of ataxia were established by multivariable linear regression models. Results: The frequency of depression in the study subjects was 57.69% (60/104), which was higher than that in SCA3 patients from a subset of other populations. The gender (p = 0.03) and severity (p < 0.01) of ataxia were those risk factors that could affect depression. Conversely, depression (p < 0.01) together with the duration (p < 0.01) of SCA3 could also play a positive role in the severity of ataxia. Conclusions: The extremely common depression results from motor disability caused by ataxia; it also affects the disease severity of SCA3. These findings suggested that depression was a part of neurodegeneration in SCA3 and necessitated intensive focus and interventions while caring for SCA3 patients.

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“…2 Psychotic symptoms are associated with more aggressive disease and a more rapid rate of decline. For example, this was demonstrated in two large cohort studies (n=335 and n=1,821) of patients with incident AD in which presence of clinically significant psychotic symptoms was strongly associated with progression from mild cognitive impairment to dementia (hazard ratios 1.47 and 2.68) and in one of these studies was associated with earlier death (hazard ratio 1.95).…”

Section: Q: How Does the Incidence Of Psychotic Episodes Affect Diseamentioning

confidence: 99%

“…For example, this was demonstrated in two large cohort studies (n=335 and n=1,821) of patients with incident AD in which presence of clinically significant psychotic symptoms was strongly associated with progression from mild cognitive impairment to dementia (hazard ratios 1.47 and 2.68) and in one of these studies was associated with earlier death (hazard ratio 1.95). 2 Patients with psychotic symptoms are also more likely to be admitted to a nursing home. An unresolved question is whether this more rapid progression is simply the result of greater disease activity or whether it is caused by exposure to treatments for the symptoms, resulting in a range of severe adverse events that negatively impact the patient's condition.…”

Section: Q: How Does the Incidence Of Psychotic Episodes Affect Diseamentioning

confidence: 99%