Neuropsychiatric manifestations of COVID-19: a literature review

Abstract

The recent emergence of COVID-19, associated with its rapid expansion and systemic involvement, leads to a lack of knowledge regarding the scope of manifestations resulting from the disease. Thus, post-COVID syndrome constitutes several persistent sequelae after the period of SARS-COV-2 infection, which have not yet been completely elucidated. This study, therefore, aims to review in the literature the conditions resulting from post-COVID syndrome in the nervous system and also psychiatric scope. Thus, psychiatric disorders, sleep disorders, cognitive deficits, neurovascular disorders, syndromes related to the central and peripheral nervous systems were observed in this condition and described in this study. Furthermore, it characterizes the risk factors related to greater involvement in certain populations, such as female sex and chronic diseases, and greater severity of COVID-19, which, in general, have a pathophysiological relationship based on the exacerbation of the inflammatory process of these conditions and that arising from SARS-COV-2 infection. It is worth highlighting the importance of the biopsychosocial aspect when observing the stressful nature generated by social isolation and its consequences.