Neuropsychiatric Inventory in Community-Dwelling Older Adults with Mild Cognitive Impairment and Dementia

Nunes, Paula; Schwarzer, Monise Caroline; Leite, Renata Elaine Paraízo; Ferretti‐Rebustini, Renata Eloah de Lucena; Pasqualucci, Carlos Augusto; Nitrini, Ricardo; Rodriguez, Roberta Diehl; Nascimento, Camila; Oliveira, Kátia C.; Grinberg, Lea T.; Jacob‐Filho, Wilson; Lafer, Beny; Suemoto, Cláudia Kimie

doi:10.3233/jad-180641

Cited by 26 publications

(27 citation statements)

References 41 publications

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“…No study has explored the predictive power of MBI in MCI development among CN subjects. The prevalence of NPI symptoms was reported to be 28.4%–85% among MCI subjects 3, 35, 37, 38 . Our pooled MBI prevalence of 45.5% among MCI subjects falls within the previously reported range.…”

Section: Discussionsupporting

confidence: 86%

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Prevalence of mild behavioural impairment: a systematic review and meta‐analysis

Pan

Shea

et al. 2020

Psychogeriatrics

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Aim Mild behavioural impairment (MBI) is a neurobehavioural syndrome characterized by emergent neuropsychiatric symptoms in later life. There has been no systematic review or meta‐analysis on the prevalence of MBI. The main aim of the study is to calculate the pooled prevalence of MBI. Methods A search of the literature on MBI in mild cognitive impairment (MCI), cognitively normal (CN), and subjective cognitive impairment (SCI) and CN but at risk (CN‐AR) subjects published between 1 January 2003 and 28 September 2020 was conducted. Meta‐analysis using a random effects model was performed to determine the pooled estimate of the prevalence of MBI. Meta‐regression was performed to identify factors contributing to the variance of prevalence rate. A systematic review was also performed to study the impact of MBI in cognitive outcomes and its correlation to the pathology and genetics of Alzheimer's disease. Results Eleven studies conducted among 15 689 subjects underwent meta‐analysis, revealing the pooled prevalence of MBI to be 33.5% (95% confidence interval (CI): 22.6%–46.6%). Seven studies conducted among 1358 MCI subjects underwent meta‐analysis, revealing the pooled prevalence to be 45.5% (95%CI: 36.1%–55.3%). Four studies conducted among 13 153 CN subjects underwent meta‐analysis, revealing the pooled prevalence to be 17.0% (95%CI: 7.2%–34.9%). Five studies conducted among 1158 SCI or CN‐AR subjects underwent meta‐analysis, revealing the pooled prevalence to be 35.8% (95%CI: 21.4%–53.2%). A systematic review of 13 studies showed that MBI has a significant impact on cognitive deterioration and is associated with the pathology and genetics of Alzheimer's disease. Conclusions In MCI, CN, and SCI and CN‐AR subjects, MBI is common. Our finding is potentially useful in planning future clinical trials.

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Section: Discussionsupporting

confidence: 86%

“…The Neuropsychiatric Inventory (NPI) was designed to detect behavioural and psychological symptoms of dementia in patients with dementia 34 . Previous studies have used the NPI to study NPS in CN and MCI subjects 3, 18, 35–38 . NPI scores ≥4 are usually considered clinically relevant 1 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of mild behavioural impairment: a systematic review and meta‐analysis

Pan

Shea

et al. 2020

Psychogeriatrics

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“…Though, it may be suggested that i) a valid rating of BPSD was incomplete in the reviewed studies by using questionnaires which are not validated in dementia (i.e. BPRS and PANNS), ii) as BPSD occurs mostly in more advanced dementia (Nunes et al, 2019 ), co-occurrence of PTSD in combination with BPSD might have been lower in the population with new-onset dementia (Ball et al, 2009 ). Accordingly, in elaborating the clinical presentation of PTSD in dementia, recurrent assessments of BPSD, with validated instruments (e.g.…”

Section: Discussionmentioning

confidence: 99%

Comorbidity rates of Posttraumatic Stress Disorder in dementia: a systematic literature review

Sobczak

Olff

Rutten

et al. 2021

European Journal of Psychotraumatology

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Background : Post Traumatic Stress Disorder (PTSD) has been described as an independent risk factor for cognitive decline and dementia. At the same time, cognitive deterioration and increased loss experiences in dementia may increase liability for the reactivation of traumatic memories and thereby PTSD symptoms. Objective : In order to investigate co-occurrence of PTSD in dementia this systematic literature review summarizes all the available evidence on reported comorbidity rates of PTSD in patients with dementia. Method : PubMed, Embase, PsycINFO and CINAHL were searched for potential publications investigating the co-occurrence of PTSD in dementia until 25 November 2019. Cohort and cross-sectional studies were included. To assure current comorbidity of PTSD in dementia, only publications with a recent PTSD diagnosis (<2 years before onset of dementia) were selected. Results : Of the 860 identified abstracts, three studies (0.35%) met the eligibility criteria and were included. These three studies concerned only military veteran populations, and they comprised two cross-sectional cohort studies and one prospective cohort study. The estimated comorbidity rate of PTSD in veterans with dementia varied between 4.7% and 7.8%. Conclusions : The limited research available shows comorbidity rates only in military veterans, which were possibly dependent on investigated population with respect to dementia severity and possibly associated behavioural and psychiatric symptoms of dementia (BPSD). In dementia patients the comorbidity with PTSD may be high and we suggest that worldwide the impact of PTSD in dementia is high and probably underestimated. Research and care on this topic should improve urgently with the current expanding prevalence of dementia. A first step to improve quality of dementia research and care would be to develop a structured tool to diagnose PTSD in these patients.

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“…We evaluated the correlation between the ABC-DS score and the global CDR score. In a previous study of the ABC-DS, scores of 13–70, 71–85, 86–100, and 101–117 corresponded to global CDR scores of 3, 2, 1, and 0.5–0, respectively [21]. In our study, ABC-DS scores of 13–58, 59–75, and 76–117 corresponded to global CDR scores of 3, 2, and 1, 0.5–0, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…DAD, NPI, CDR, and MMSE have been used to evaluate ADL, BPSD, and cognitive function in various dementias, as well as in diseases that cause dementia symptoms, whereas DLB and FTLD are disease-specific evalu-ation scales. DAD, NPI, CDR, and MMSE are utilized frequently [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Concurrent Validity of the ABC Dementia Scale with Other Standard Scales: A New Comprehensive Instrument for Assessing Dementia in Japan

Shimoda

Murata²,

Nakatani³

et al. 2020

Dement Geriatr Cogn Disord

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Background/Aims: The ABC Dementia Scale (ABC-DS), a new tool for evaluating dementia, was developed in Japan. The ABC-DS is a comprehensive instrument that can simultaneously evaluate activities of daily living (ADLs), behavioral and psychological symptoms of dementia (BPSD), and cognitive function. The ABC-DS can be administered easily and quickly and can clarify the severity of dementia and its changes over time. While the ABC-DS has been reported to be useful in Alzheimer disease (AD)-type dementia, it has not yet been studied in other types of dementia. The purpose of this study was to reevaluate the standard validity of ABC-DS separately for various dementia types and severities. Methods: We evaluated the ABC-DS in outpatients at 1 hospital in Nagasaki Prefecture and patients who use the facility. Domain A, corresponding to ADLs, correlated with Disability Assessment for Dementia (DAD); domain B, corresponding to BPSD, correlated with the Neuropsychiatric Inventory (NPI); domain C, corresponding to cognitive functions, correlated with Mini-Mental State Examination (MMSE); and the total score of the ABC-DS correlated with the Clinical Dementia Rating (CDR). Results: 102 patients, comprising 38 males and 64 females with an average age of 80.7 ± 8.6 years, were enrolled. AD-type dementia was present in 38 cases, vascular dementia (VaD) in 23, mixed dementia in 23, dementia with Lewy bodies in 6, argyrophilic grain dementia in 9, and mild cognitive impairment in 3. A strong correlation was found between ABC-DS domain scores and their respective reference neuropsychological instruments (domain A and the DAD, domain B and the NPI, domain C and the MMSE, and total score and CDR). The correlation of each ABC-DS domain score with the corresponding standard scale depended on the type and severity of dementia, and we observed moderate or high correlations in AD and VaD patients with moderate and severe dementia. Discussion: Although the ABC-DS targets AD, it can be used in VaD based on the results of this study. In other types of dementia, the results differed depending on the domain; in some conditions, the ABC-DS may not show sufficient concurrent validity with other standard scales. Also, the ABC-DS is more beneficial for moderate-to-severe dementia, as reported in previous studies. It is highly useful in clinical practice in Japan since there more than half of all patients have moderate-to-severe dementia.

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Neuropsychiatric Inventory in Community-Dwelling Older Adults with Mild Cognitive Impairment and Dementia

Cited by 26 publications

References 41 publications

Prevalence of mild behavioural impairment: a systematic review and meta‐analysis

Prevalence of mild behavioural impairment: a systematic review and meta‐analysis

Comorbidity rates of Posttraumatic Stress Disorder in dementia: a systematic literature review

Concurrent Validity of the ABC Dementia Scale with Other Standard Scales: A New Comprehensive Instrument for Assessing Dementia in Japan

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