Neuropsychiatric Impairments as Predictors of Mild Cognitive Impairment, Dementia, and Alzheimer's Disease

Stepaniuk, Janet; Ritchie, Lesley; Tuokko, Holly

doi:10.1177/1533317508317351

Cited by 39 publications

(46 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After controlling for initial cognitive status, loss of interest and depression contributed signifi cantly to the prediction of MCI, dementia, and AD over time. These fi ndings suggest that these neuropsychiatric symptoms play signifi cant roles throughout the course of cognitive decline [26].…”

Section: Historical Cohorts and Longitudinal Studies: Neuropsychiatrimentioning

confidence: 89%

“…Stepaniuk et al [26] cross-sectionally and longitudinally investigated the relationship between cognitive status and neuropsychiatric impairments in nondemented older adults using data from the Canadian Study of Health and Aging (CSHA). These longitudinal data were collected three times (CSHA-1, CSHA-2, and CSHA-3) at 5-year intervals.…”

Section: Historical Cohorts and Longitudinal Studies: Neuropsychiatrimentioning

confidence: 99%

See 1 more Smart Citation

Psychological distress and risk for dementia

Simard

Hudon²,

Reekum³

2009

Curr Psychiatry Rep

View full text Add to dashboard Cite

The concept of mild cognitive impairment (MCI) primarily emphasizes changes in individuals' mental abilities, but it has recently been suggested that neuropsychiatric symptoms should also be considered important factors in age-related neurodegeneration. Psychological distress, defined as a reaction of an individual to external and internal stresses, is characterized by a mixture of psychological symptoms. It also may be considered a neuropsychiatric symptom encompassing depression, anxiety, and apathy. This paper reviews and summarizes recent evidence and relevant issues regarding the presence of psychological distress in healthy older adults and MCI patients and its relationship to risk for developing dementia. Results presented in this review show that psychological distress and depressive, anxious, and apathetic symptoms can be present in MCI and may predict progression to dementia. This article also provides suggestions for future research.

show abstract

Section: Historical Cohorts and Longitudinal Studies: Neuropsychiatrimentioning

confidence: 89%

Section: Historical Cohorts and Longitudinal Studies: Neuropsychiatrimentioning

confidence: 99%

Psychological distress and risk for dementia

Simard

Hudon²,

Reekum³

2009

Curr Psychiatry Rep

View full text Add to dashboard Cite

show abstract

“…In this study, the cognitively impaired group demonstrated significantly more severe depressive symptoms than did the cognitively acceptable group. This result was consistent with previous studies (Ravaglia et al ., 2008;Stepaniuk et al ., 2008). Approximately 83% of mild dementia patients assessed in a study, whose MMSE scores were 15 to 23, had depression and a higher prevalence of suicidal ideation (Kim and Hyun, 2013).…”

Section: Discussionmentioning

confidence: 99%

Depression and suicidal ideation in community-dwelling older adults in Korea

Kwon¹,

손명지²

2014

Journal of the Korean Data and Information Science Society

View full text Add to dashboard Cite

This study aimed to investigate the prevalence of depression and suicidal ideation in community-dwelling older adults in Korea, as well as identify factors associated with their occurrence, including cognitive impairment. A cross-sectional study of 484 residents was conducted at a senior centre utilising the PHQ-9K and K-MMSE. Demographic data were also collected for analysis. Of the respondents, 38.1% had symptoms of mild to severe depression. Further, 16.7% reported having suicidal ideation, with 5% of respondents having thoughts of suicide every day. The majority of participants had 'normal' scores on the K-MMSE (88.0%), though significant differences were observed in PHQ-9K scores between cognitive-acceptable and cognitive-impaired groups. Depressive symptoms and suicidal ideation were very prevalent in community-dwelling older adults in Korea. This study indicates the need for the development of communitybased mental health programs tailored to older adults, and demonstrates the viability of promoting early detection of depressive symptoms through senior centres.

show abstract

“…[6][7][8][9][10] Moreover, increasing social pressure as one of the causes of depression has become an important issue in modern societies. At our institution, the number of not only older but also younger patients with malaise including depression who require MRI analysis has been increasing.…”

Section: Discussionmentioning

confidence: 99%

“…In the presence of aging societies, the diagnosis of Alzheimer's disease and other dementias is becoming increasingly important using this imaging technology. [1][2][3][4][5] Many studies have suggested that depressive symptoms are likely to be associated with mild cognitive impairment [6][7][8][9][10] ; and thus in the clinical setting, MRI is often performed in many patients with malaise, including headache, numbness, vertigo, and depression simply to detect the early stages of dementia. Over the last 2-3 years, the number of not only older but also younger patients requiring MRI for malaise has increased.…”

Section: Introductionmentioning

confidence: 99%