Neuropsychiatric Disorders in Chronic Kidney Disease

Silva, Ana Cristina Simões e; Miranda, Aline Silva de; Rocha, Natália Pessoa; Teixeira, Antônio Lúcio

doi:10.3389/fphar.2019.00932

Cited by 76 publications

(60 citation statements)

References 117 publications

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“…We found that male participants had significantly higher creatinine than females in the ASD-P, which was in accordance with the fact that creatinine is usually higher in men than in women (29). Although urinary creatinine level is also closely related to kidney function and psychiatric disorders and depression, anxiety and cognitive disorders are common in patients with kidney diseases (30,31), creatinine levels between ASD-P and the Control were comparable among participants in this study. Therefore, creatinine was not considered as a biochemical indicator of psychological or physical problems caused by kidney function disorders among parents of autistic children.…”

Section: Discussionsupporting

confidence: 87%

“…It was the first time that NO metabolites were precisely reported in the parents of children with autism. In order to better understand the role of NO in the ASD-P population, we also provided demographic information for parents in the ASD-P group (43), their children (31), participants in the Control group (43) and participants in the Control group (40) (Supplementary Tables 5, 6).…”

Section: Serum Nitrate In the Asd-p And S-control Groupsmentioning

confidence: 99%

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Urine Nitric Oxide Is Lower in Parents of Autistic Children

et al. 2021

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Parents raising children with autism spectrum disorder (ASD) usually carry on their daily life under tremendous stress, but limited empirical research has been devoted to this population. It is known that parents' health status directly impacts therapeutic outcome of ASD children. As an important regulator in cardiovascular, nervous and immune systems, nitric oxide (NO) levels haven't been reported in parents of ASD children yet. In this study, we measured urine nitrite and nitrate from 43 ASD parents (ASD-P), and 43 healthy adults in the same range of age (Control) who didn't have any ASD descendants. Comparison between the ASD-P and Control groups showed that NO2-, NO3-, and NO2-/NO3- were all significantly lower in the ASD-P group. Analysis on the interaction effect of sex and group indicated that urine NO3- of mothers in ASD-P was lower than that in females of the Control group, but no significant difference was observed between males in both groups. It is for the first time that urine nitric oxide metabolites (nitrite, nitrate) levels were precisely reported to differentiate parents of autistic children from other adults without ASD descendants. This phenomenon suggests that parents (especially mothers) of autistic children might have experienced more mental and physical stressors, which led to decreased NO levels during metabolism. Further investigations are necessary to uncover the etiology of low urine NO among parents of autistic children.

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Section: Discussionsupporting

confidence: 87%

Section: Serum Nitrate In the Asd-p And S-control Groupsmentioning

confidence: 99%

Urine Nitric Oxide Is Lower in Parents of Autistic Children

et al. 2021

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“…Possible consequences of modifications to health resources on accessibility and reliability and performance of psychiatric services throughout the COVID-19 pandemic ( 16 ). Phobic anxiety, impulse purchase, and television addiction, all linked to psychological disruptions, insomnia, exhaustion, and consciousness deterioration, have been documented, and digital networking has been linked to heightened anxiety and depression-associated anxiety ( 17 – 19 ).…”

Section: Interaction Between Covid-19 and Psychological Well-beingmentioning

confidence: 99%

Impacts of COVID-19 Pandemic on Psychological Well-Being of Older Chronic Kidney Disease Patients

Chan

et al. 2021

Front. Med.

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COVID-19 pandemic has been a major global issue, its eventual influences on the population welfare, global markets, public security, and everyday activities remain uncertain. Indeed, the pandemic has arisen a significant global threat. Its psychological impact is predicted to be severe and enduring, but the absolute magnitude is still largely unclear. Chronic kidney disease (CKD) is a complication markedly contributes to the mortality of COVID-19 cases, meanwhile several studies have demonstrated the high frequency and seriousness of the COVID-19 in CKD patients receiving dialysis. Importantly, the influence of COVID-19 among CKD patients without dialysis is still largely unexplored. Thus, we systemically summarized how mental health affects the spreading of COVID-19 to virtually worldwide, covering perspectives from several countries across a wide range of fields and clinical contexts. This review aims to provide the latest details and reveal potential concerns on the public health including psychological well-being of the older patients with CKD.

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“…One in five adults with CKD in the US suffers from depression. Patients on dialysis have a higher prevalence of depression and a higher risk of hospitalizations due to psychiatric dysfunction compared to their pre-dialysis and post-transplant counterparts [3]. Behavioral factors such as the burden of self-care decreased day-to-day functionality, and the psychological impact of having a chronic illness also contribute to developing depression [4].…”

Section: Introductionmentioning

confidence: 99%

Depression Impairs Level of Functioning in Chronic Kidney Disease Inpatients: A Case-Control Study

Virani¹,

Shah²,

Haneef³

et al. 2021

Cureus

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To evaluate the difference in demographics and clinical correlates during hospitalization for chronic kidney disease (CKD) between patients with depression and those without depression, and its impact on the severity of illness and in-hospital mortality. MethodsWe conducted a case-control study and included 2,296 adult inpatients (age ≥18 years) with a primary discharge diagnosis of CKD using the nationwide inpatient sample (NIS). We used propensity score matching to extract the cases i.e., CKD inpatients with depression (N = 1,264) and the controls i.e. CKD inpatients without depression (N = 1,032). The matching was done based on demographic characteristics of age at admission, sex, race, and median household income. Our outcomes of interest are the severity of illness and all-cause in-hospital mortality. All patient refined drg (APR-DRG) are allocated using health information systems software by the NIS and the severity of illness within each base APR-DRG was classified into minor, moderate, or major loss of body functions. Binomial logistic regression analysis was conducted to find the odds ratio (OR) of association for major loss of function in CKD inpatients with depression, and this model was adjusted for potential confounders of congestive heart failure (CHF), coronary artery disease (CAD), diabetes, hypertension, obesity, and tobacco abuse, and utilization of hemodialysis. ResultsA higher proportion of CKD inpatients with depression had a statistically significant higher prevalence of major loss of function (49.8% vs. 40.3% in non-depressed). There was a statistically significant difference with higher utilization of hemodialysis in CKD inpatients with depression (76.2% vs. 70.7% in nondepressed). The all-cause in-hospital mortality rate was lower in CKD inpatients with depression (2.1% vs. 3.5% in non-depressed). After controlling the logistic regression model for potential comorbidities and utilization of hemodialysis, depression was associated with increased odds (OR 1.46; 95% CI 1.227 -1.734) for major loss of function versus in non-depressed CKD inpatients ConclusionComorbid depression increases the likelihood of major loss of functioning in CKD inpatients by 46%. Treating depression can allow patients to better cope emotionally and physically with CKD and other comorbidities and significantly improve the patient's quality of life (QoL) and health outcome.

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Neuropsychiatric Disorders in Chronic Kidney Disease

Cited by 76 publications

References 117 publications

Urine Nitric Oxide Is Lower in Parents of Autistic Children

Urine Nitric Oxide Is Lower in Parents of Autistic Children

Impacts of COVID-19 Pandemic on Psychological Well-Being of Older Chronic Kidney Disease Patients

Depression Impairs Level of Functioning in Chronic Kidney Disease Inpatients: A Case-Control Study

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