Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability

Schmidt, Sergio L.; Silva, Michele Santos da; Schmidt, Juliana J; Carvalho, Ana Lúcia Novais; Vasconcelos, Cláudia Cristina Ferreira; Paes, Renata Alves; Boechat, Yolanda; Neder, Rafael; Alvarenga, Regina

doi:10.2147/ndt.s163480

Cited by 4 publications

(3 citation statements)

References 28 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seven studies did not demonstrated an association between education level and cognitive performance, 39 , 44 , 46 , 47 , 65 , 125 , 135 while 10 showed that persons with fewer years of education have greater levels of impairment. 17 , 18 , 21 , 30 , 37 , 52 , 72 , 111 , 113 , 144 For instance, Bonnet et al 72 found that persons with early MS who had low educational levels (<12 years or no schooling) were impaired on 13 out of 15 cognitive tests, while persons with high education levels were only impaired on three measures. Persons’ education level has also been utilized as a marker for cognitive reserve.…”

Section: Resultsmentioning

confidence: 99%

Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis

Gromisch

Dhari

2021

NDT

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a debilitating disease of the central nervous system that is most commonly seen in early to middle adulthood, although it can be diagnosed during childhood or later in life. While cognitive impairment can become more prevalent and severe as the disease progresses, signs of cognitive involvement can be apparent in the early stages of the disease. In this review, we discuss the prevalence and types of cognitive impairment seen in early MS, including the specific measures used to identify them, as well as the challenges in characterizing their frequency and progression. In addition to examining the progression of early cognitive involvement over time, we explore the clinical factors associated with early cognitive involvement, including demographics, level of physical disability, disease modifying therapy use, vocational status, and psychological and physical symptoms. Given the prevalence and functional impact these impairments can have for persons with MS, considerations for clinicians are provided, such as the role of early cognitive screenings and the importance of comprehensive neuropsychological assessments.

show abstract

Section: Resultsmentioning

confidence: 99%

Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis

Gromisch

Dhari

2021

NDT

View full text Add to dashboard Cite

show abstract

“…Furthermore, correlation between EDSS progression and reduction in SDMT performance has been demonstrated [ 67 , 64 ]. Patient’s education level should be considered when making decisions based on test results [ 68 ].…”

Section: Methodsmentioning

confidence: 99%

Outcome measures assisting treatment optimization in multiple sclerosis

2021

View full text Add to dashboard Cite

Objective To review instruments used to assess disease stability or progression in persons with multiple sclerosis (pwMS) that can guide clinicians in optimizing therapy. Methods A non-systematic review of scientific literature was undertaken to explore modalities of monitoring symptoms and the disease evolution of MS. Results Multiple outcome measures, or tools, have been developed for use in MS research as well as for the clinical management of pwMS. Beginning with the Expanded Disability Status Scale, introduced in 1983, clinicians and researchers have developed monitoring modalities to assess all aspects of MS and the neurological impairment it causes. Conclusions Much progress has been made in recent decades for the management of MS and for the evaluation of disease progression. New technology, such as wearable sensors, will provide new opportunities to better understand changes in function, dexterity, and cognition. Essential work over the decades since EDSS was introduced continues to improve our ability to treat this debilitating disease.

show abstract

“…There is an emerging interest on the study of cognitive dysfunction in Brazilian patients with MS [17][18][19][20] 21 . Conversely, Damasceno et al showed that patients with relapsing-remitting MS evolved with cognitive decline even if they had minimal or no evidence of disease activity 22,23 .…”

Section: Introductionmentioning

confidence: 99%

Cognitive assessment of Brazilian patients with multiple sclerosis: weighing the impact of disability and depressive symptoms

Andrade

Cerqueira

Colodetti

et al. 2022

Dement. neuropsychol.

View full text Add to dashboard Cite

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. Cognition is not routinely assessed in patients with MS though they frequently have cognitive complaints or dysfunction. Objective: The aim of this study was to compare the cognitive status of patients with MS with age, sex, and schooling matched controls and to evaluate the potential influence of clinical parameters on cognition. Methods: A total of 35 patients with MS (mean±SD age 37.9 years±11.44, M/F: 12/23) and 33 healthy controls (mean±SD age 38.8 years±12.6, M/F: 12/21) were enrolled in this study. All subjects underwent a structured clinical assessment and the cognitive tools are as follows: Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), Rey Auditory Verbal Learning Test (RAVLT), Digit Span, and Verbal Fluency Tests (letters F, A, and S and animal category). Psychopathology was assessed with the Mini International Neuropsychiatric Interview and the Beck Depression Inventory (BDI). The Expanded Disability Status Scale (EDSS) was used for patients. Results: Patients performed worse than controls in almost all tests, with approximately 70% of patients presenting cognitive impairment. The most affected cognitive domain was episodic memory (45.7%), followed by verbal fluency (42.8%) and information processing speed (22.8%). SDMT was inversely correlated with disease severity, as assessed by the EDSS. Depression did not influence cognitive performance in this cohort. Conclusions: Cognitive dysfunction is common among patients with MS. While motor impairment was associated with information processing speed, depression did not influence cognitive performance.

show abstract

Neuropsychiatric assessments in patients with multiple sclerosis in early phases and with low disability

Cited by 4 publications

References 28 publications

Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis

Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis

Outcome measures assisting treatment optimization in multiple sclerosis

Cognitive assessment of Brazilian patients with multiple sclerosis: weighing the impact of disability and depressive symptoms

Contact Info

Product

Resources

About