Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain

Srivastava, Rajnish; Tripathi, Laxmi; Swain, Sudhansu Ranjan; Singh, J.

doi:10.1080/13813455.2021.1884725

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…Neuropathy, characterized by spontaneous pain, allodynia, and hyperalgesia, develops in about 50% of diabetic patients throughout the disease. 29 A STZ-induced diabetic rat model is utilized to imitate chronic neuropathic pain with hyperalgesia and allodynia experienced by diabetic patients. 30 STZ causes hyperglycemia and thereby altering the nociceptive response.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Potential of Hygrophila auriculata Targeting Oxidative Stress-Mediated Deficits in Streptozotocin-Induced Sciatic Nerve Injury

Jadhav,

Vaghela

2024

Journal of Health and Allied Sciences NU

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Objective Diabetic neuropathy, a microvascular complication of diabetes, affects 50% of individuals. Addressing this challenge is challenging due to its poorly understood origin and existing therapeutic approaches. This study used a methanolic extract from Hygrophila auriculata (MEHA) to treat oxidative stress-induced sciatic nerve injury in diabetic rats. Materials and Methods A study was conducted to assess the nociceptive reflex after a single streptozotocin (STZ) (45 mg/kg intraperitoneal.) injection. The rats were divided into six groups (n = 6 rats per group). Group I nondiabetic (ND) rats received oral gavage of 1% carboxymethyl cellulose (CMC). The diabetic rats in groups II to VI were given 1% CMC, 100, 200, and 400 mg/kg of MEHA, and 180 mg/kg of metformin (MET). The freshly prepared 1% (w/v) CMC suspension of both MEHA and MET was administered over a 4-week period, commencing from the 28th day through the 56th day post-STZ injection. The impact of STZ-induced sciatic nerve injury was analyzed through the estimation of serum glucose and glycohemoglobin levels, paw withdrawal and tail-flick latencies, oxidative stress markers, and neural histoarchitecture. Results Diabetic (STZ) control group II showed significantly altered serum glucose and glycohemoglobin levels, a reduced paw withdrawal threshold, and reduced paw withdrawal and tail-flick latencies in contrast to ND group I. Furthermore, increased oxidative stress in the sciatic nerve correlates with a reduced nociceptive threshold and disrupted neural histoarchitecture in diabetic rats. These behavioral, biochemical, and molecular changes were markedly and dose-dependently reduced by MEHA and MET treatments. Conclusion The antioxidant efficacy of MEHA modulated oxidative stress in STZ-sensitized diabetic rats and corrected neuropathic pain by attenuating hyperglycemia.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Potential of Hygrophila auriculata Targeting Oxidative Stress-Mediated Deficits in Streptozotocin-Induced Sciatic Nerve Injury

Jadhav,

Vaghela

2024

Journal of Health and Allied Sciences NU

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“…Anti-diabetic effects have been associated with flavonoids, which are widely found in citrus peels (Ahmed et al, 2017). Soluble fiber and pectin extracted from orange peel have been associated with glucose improvement and lower plasma lipid levels (Srivastava et al, 2021). Ahmed et al (2017) demonstrated the anti-hyperglycemic, anti-hyperlipidemic, and antioxidant effects in diabetic rats due to the content of naringin and naringenin present in the orange peel extract.…”

Section: Discussionmentioning

confidence: 99%

The biological effect of orange (Citrus sinensis L.) by-products on metabolic biomarkers: A systematic review

Pineda-Lozano

Fonseca-Bustos

Moreno

et al. 2022

Front. Sustain. Food Syst.

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Industrial processing of citrus fruits generates an important amount of wastes that evoke environmental damage. Orange is the main citrus fruit consumed worldwide, and after its use, approximately more than a half of the fruit remains as by-products, which comprise important bioactive compounds useful for the development of promising nutraceuticals for the treatment of non-communicable diseases. This study aimed to gather scientific evidence about the biological effects of orange by-products using a systematic review. A total of 14 studies that were carried out in rodent models in the last 10 years were retrieved from PubMed and ScienceDirect databases. Studies that used another animal species, another type of citrus, or a combination of orange with other citrus were excluded. The risk of bias was assessed by using the SYRCLE RoB tool, and the results obtained are shown in an informative table, which showed that most of the studies used a pathological model of chronic diseases. We found that the peel is the most used agri-food by-product, and that it has the potential of reducing the levels of triglycerides, total cholesterol, glucose, and systolic blood pressure. However, to clinically assess these effects, these results need to be tested in future in humans. The included studies on the use of orange by-products strengthen the global sustainable food agenda. It is important to consider new research directions about the use of citrus fruit residues since it not only impacts the problem of its disposal but also provides solutions to eliminate the resulting contamination.

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“…Lipid abnormalities are considered to be the most important biomarkers of diabetes. In addition, excess lipid production and accumulation of LDL-C lead to the development of insulin resistance and hypertriglyceridemia, 31 and excessive accumulation of LDL-C and significant reduction of HDL-C can also increase the risk of cardiovascular diseases. 32,33 Both GOP and MGOP intake significantly decreased the TC and TG levels, and significantly increased the HDL-C levels.…”

Section: Food and Function Papermentioning

confidence: 99%

Anti-diabetic effects of natural and modified ‘Ganzhou’ navel orange peel pectin on type 2 diabetic mice via gut microbiota

Du,

Zuo,

Cao

et al. 2023

Food Funct.

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Neuroprotective validation of pectin in T2DM-induced allodynia and hyperalgesia in diabetic peripheral neuropathic pain

Cited by 8 publications

References 48 publications

Neuroprotective Potential of Hygrophila auriculata Targeting Oxidative Stress-Mediated Deficits in Streptozotocin-Induced Sciatic Nerve Injury

Neuroprotective Potential of Hygrophila auriculata Targeting Oxidative Stress-Mediated Deficits in Streptozotocin-Induced Sciatic Nerve Injury

The biological effect of orange (Citrus sinensis L.) by-products on metabolic biomarkers: A systematic review

Anti-diabetic effects of natural and modified ‘Ganzhou’ navel orange peel pectin on type 2 diabetic mice via gut microbiota

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