Neuroprotective roles of total flavones of Camellia on early brain injury andcognitive dysfunction following subarachnoid hemorrhage in rats

Lu, Weizhuo; Wen, Jiyue

doi:10.1007/s11011-020-00567-6

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…71 Total flavones of Camellia at doses of 40 and 80 mg/kg reduced MDA level in brain tissues. 72 The MDA was significantly reduced in the brains of mice treated with gallic acid and green tea leaf extract. 73 The 95% ethanol extract obtained from fresh leaves of C. sinensis at a dosage of 200 mg/kg significantly reduced serum and hepatic MDA concentration in rats.…”

Section: Discussionmentioning

confidence: 94%

Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam

Chau

Hương

et al. 2023

Pharmacognosy Magazine

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Background Leaves, flowers and young shoots of yellow Camellia species are often used as a substitute for green tea in Vietnam. Yellow Camellia species contain high levels of polyphenol compounds, and have shown activities such as antioxidant, anticancer, and cytotoxic. Objectives We qualitatively screened phytochemicals, quantified total polyphenols of 70% ethanol (EtOH) extracts of leaves, young shoots, and flowers of Camellia vuquangensis and Camellia hatinhensis in Ha Tinh Province, Vietnam. Furthermore, these extracts have been evaluated for lipid peroxidation inhibitory activities at the in vivo level in the BALB/c mouse model, and in vitro cytotoxic activities. Materials and Methods Chemical methods and thin-layer chromatographic (TLC) analysis were used for the qualitative screening of phytochemicals. High-performance liquid chromatography (HPLC) was used to determine total polyphenols. Cell survival was determined through optical density (OD) measured when the protein composition of the cells was stained with sulforhodamine B (SRB). Inhibition of lipid peroxidation was evaluated by determining the content of malondialdehyde (MDA), which is a product of membrane lipid peroxidation. Results The total polyphenol contents of all parts of the two species were comparable to that of green tea with values between 319.3 and 342.6 mg gallic acid equivalents (GAE/g) dry weight. Extracts of leaves, flowers of C. vuquangensis and C. hatinhensis showed strong lipid peroxidation inhibitory activities (IC50: 7.92–17.45 µg/mL) and moderate cytotoxic activities against cell lines HepG2, A549, MCF7, SK-Mel-2, HT-29, and AGS (IC50: 34.73–80.58 µg/mL). Conclusion These two tea species may be considered as herbal teas with various health benefits.

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Section: Discussionmentioning

confidence: 94%

Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam

Chau

Hương

et al. 2023

Pharmacognosy Magazine

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“…The levels of LDH in CSF were determined using a specific LDH assay kit (Jiancheng Biotech, China). Results were presented corresponding to the relevant standard curves [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage

Liang,

Zhu,

Gong

et al. 2023

Aging

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Background: Intracerebral hemorrhage (ICH) is a stroke subtype with high mortality and disability rate, and neuroinflammation is involved in secondary brain injury. Galectin-3 (Gal-3) is one of the scaffold proteins of Galectins. Studies have indicated that Gal-3 plays an important role in the physiological and pathological state of the nervous system. Here we focus on the role of Gal-3 in ICH, especially in neuroinflammation. Methods: Injection of autologous blood into the right basal ganglia was used to simulate ICH injury, and the level of Gal-3 in brain was regulated by related means. The changes of Gal-3 were detected by western blot and immunofluorescence, the level of neuroinflammation by immunofluorescence staining and ELISA. Apoptosis and neuron loss were detected by TUNEL staining FJB staining and Nissl staining, and neurological deficits were judged by neurobehavioral tests. Results: The protein level of Gal-3 increased at 24 h after ICH. Downregulation of Gal-3 level can reduce the infiltration of M1-type microglia and peripheral inflammatory cells, thus alleviating post-ICH neuroinflammation, and reducing cell apoptosis and neuron loss in brain tissue. ICH-induced neurological damage was rescued. Meanwhile, the promotion in the expression level of Gal-3 increased neuroinflammatory activation and nerve cell death, aggravating ICH-induced brain injury. Conclusions: This study proves that Gal-3 is involved in neuroinflammation and nerve damage after ICH. Gal-3 expression should not be encouraged early on to prevent neuroinflammation. which provides a new possibility for clinical treatment for ICH patients.

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“…twigs and leaves, and Vitis vinifera L. (grapes) seeds contain abundant polyphenols that can act as powerful antioxidants that can reduce aging process and act as potential neuroprotective. [ 123,143 ] The rhizomes, leaves, seeds and embryo of Nelumbo nucifera Gaertn., have been long used as folk medicine in both Ayurvedic, TCM ( Lian Zi Xin ) and oriental medicine for its ability to overcome nervous disorders and tissue inflammation. Recent studies also support the use of lotus as a neuroprotective agent against AD.…”

Section: Medicinal Plants As Aβ and Tau Aggregation Inhibitorsmentioning

confidence: 99%

Ethnobotanical significance of medicinal plants: Beta‐amyloid and tau aggregation inhibitors against Alzheimer's disease

Ganapathy

Haripriya

Acharya

et al. 2023

J Biochem & Molecular Tox

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Among the various neurodegenerative disorders, Alzheimer's disease (AD) is identified as one of primary causes of dementia in the elderly, which progresses slowly leading to cognitive decline and ability to function independently. Although various pathological mechanisms have been proposed, the exact mechanism is not yet elucidated. Numerous processes such as old age, mitochondrial dysfunction, and genetics lead to the aggregation of beta-amyloid (Aβ) as amyloid plaques and tau proteins as neurofibrillary tangles in the neurons leading to their death and destruction, finally leading to AD. The current treatment measures can only temporarily improve the symptoms, slowing cognitive decline without any effect on AD pathology for better therapeutic effect. Furthermore, the high failure rates of a number of drugs during clinical trials due to their side effects has led the researchers to focus on alternative sources for drug development. As natural ingredients were considered the primary line of treatment in the olden days, and as several medicinal plant products are also proven as effective AD targets, it will be wise to investigate those with significant ethnobotanical value as potential neuroprotectives, nootropics or memory boosters. Throughout the study, propanoids, glycosides, iridoids, carotenoids and flavonoids that show potential anti-inflammatory, antioxidant, and anti-cholinesterase were also found to be inhibitors of Aβ and tau aggregation, where Saikosaponin C, Fisetin, and Morin can act as dual inhibitors. The review provides an insight in the need for proper and complete scientific evaluation of these ethnobotanically useful medicinal plants to be identified as potential leads in AD therapy.

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Neuroprotective roles of total flavones of Camellia on early brain injury andcognitive dysfunction following subarachnoid hemorrhage in rats

Cited by 6 publications

References 37 publications

Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam

Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam

Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage

Ethnobotanical significance of medicinal plants: Beta‐amyloid and tau aggregation inhibitors against Alzheimer's disease

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