Neuroprotective Roles of Apelin-13 in Neurological Diseases

Zhang, Yang; Jiang, Weiwei; Sun, Wenjie; Guo, Weiming; Xia, Beibei; Shen, Xiangru; Fu, Mingyuan; Wan, Teng; Yuan, Mei

doi:10.1007/s11064-023-03869-0

Cited by 13 publications

(8 citation statements)

References 136 publications

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“…Taking into account the biological role of the adipokines and myokines under study, their changing pattern in the blood is their protective role in obesity development. Tus, high leptin level promotes lipid catabolism and inhibits lipogenesis [18], and increased apelin lowers lipotoxicity and provides cardio-and neuroprotectivity together with activation of adipocytes proliferation and angiogenesis [19][20][21][22]. In its turn, upregulated irisin limits the energy imbalance in the body, decreases insulin resistance by increasing tissue sensitivity to insulin, promotes β-cell proliferation in the islets of Langerhans, prevents cardiovascular disease progression, inhibits the production of proinfammatory cytokines by adipose tissue, acts as a messenger of metabolic communication between the tissues, and so on [23][24][25][26][27].…”

Section: Resultsmentioning

confidence: 99%

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants

Shestopalov,

Davydov,

Tumanyan

et al. 2023

Journal of Obesity

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Obesity develops largely due to genetic factors, with the genetic polymorphism of lipid metabolism enzymes being of particular importance. However, it is still unclear how the genetic variants of one of the key enzymes in lipid transport, lipoprotein lipase (LPL), are associated with the endocrine function of mesenchymal tissues in obesity. The current study was aimed at the investigation of the LPL rs328 gene variant association with adipokines and myokines levels, as well as lipid metabolism indices in the blood of children and adolescents of both genders with obesity. We found that LPL polymorphism rs328 is not characterized by the differences in the levels of hormones, adipokines, and myokines and in the blood of healthy children and adolescents; however, it significantly affects these indices during obesity in gender-dependent manner. The shifts in hormones, adipokines, and myokines manifest mostly in the obese individuals with Ser447Ser genotype rather than with 447Ter genotype. Obese boys homozygous for Ser447Ser have more elevated leptin levels than girls. They also demonstrate lower adiponectin, apelin, prolactin, and osteocrine levels than those in obese girls with the same genotype. The gender-based differences are less pronounced in individuals with 447Ter genotype than in the homozygotes for 447Ser. Thus, we conclude that the polymorphism rs328 of the lipoprotein lipase gene is accompanied by the changes in hormones, adipokines, and myokines levels in the blood of children and adolescents with obesity in gender-dependent manner.

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Section: Resultsmentioning

confidence: 99%

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants

Shestopalov,

Davydov,

Tumanyan

et al. 2023

Journal of Obesity

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“…Apelin-13 has a multisystemic protective effect and is involved in the regulation of various pathophysiological mechanisms such as apoptosis, neuroinflammation, angiogenesis, and oxidative stress. It is currently the subject of extensive research involving the nervous system [120].…”

Section: Apelin-13mentioning

confidence: 99%

The Fetal Alcohol Spectrum Disorders—An Overview of Experimental Models, Therapeutic Strategies, and Future Research Directions

Król,

Skowron,

Skowron

et al. 2024

Children

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Since the establishment of a clear link between maternal alcohol consumption during pregnancy and certain birth defects, the research into the treatment of FASD has become increasingly sophisticated. The field has begun to explore the possibility of intervening at different levels, and animal studies have provided valuable insights into the pathophysiology of the disease, forming the basis for implementing potential therapies with increasingly precise mechanisms. The recent reports suggest that compounds that reduce the severity of neurodevelopmental deficits, including glial cell function and myelination, and/or target oxidative stress and inflammation may be effective in treating FASD. Our goal in writing this article was to analyze and synthesize current experimental therapeutic interventions for FASD, elucidating their potential mechanisms of action, translational relevance, and implications for clinical application. This review exclusively focuses on animal models and the interventions used in these models to outline the current direction of research. We conclude that given the complexity of the underlying mechanisms, a multifactorial approach combining nutritional supplementation, pharmacotherapy, and behavioral techniques tailored to the stage and severity of the disease may be a promising avenue for further research in humans.

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“…У девочек -гомозигот по аллели Arg192 имеет место существенное повышение концентрации апелина в крови. Принимая во внимание роль этого адипокина в регуляции метаболизма глюкозы и липидов, а также его кардиопротекторные и нейропротекторные свойства, влияние на пролиферацию клеток и участие в ангиогенезе [14,15], можно допустить появление у них особенностей в процессе развития ожирения [16,17].…”

Section: описание медицинского вмешательстваunclassified

“…Все эти сдвиги приобретают защитную роль в организме при ожирении. Так, повышение уровня лептина играет важное значение в усилении катаболизма липидов и ограничении липогенеза в жировой ткани [18], рост содержания апелина -приводит к снижению липотоксичности и возникновению кардиопротективного и нейропротективного действия [14,15], а увеличение уровня ирисина ограничивает нарушение энергетического баланса в организме при ожирении, увеличивает чувствительность тканей к инсулину, снижая тем самым инсулинорезистентность, способствует пролиферации β-клеток островков Лангерганса, предупреждает прогрессирование сердечно-сосудистых заболеваний, тормозит продукцию провоспалительных цитокинов жировой тканью, выступает в роли медиатора коммуникации метаболизма между различными тканями организма и др. [19][20][21][22].…”

Section: научное исследованиеunclassified

The content of adipokines and myokines in the blood of children and adolescents with different genotypes according to the polymorphism rs662 of the paraoxonase-1 gene

Shestopalov,

Davydov,

Tumanyan

et al. 2023

Obes. metabol.

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BACKGROUND. Among the many causes of obesity, genetic factors occupy a special place. An obvious role among them belongs to the genetic polymorphism of lipid metabolism enzymes, including paraoxonase-1 (PON-1). Until now, the character of the relationship between PON-1 polymorphism and the state of the endocrine function of mesenchymal tissues remains unclear. Its study will clarify the subtle mechanisms of the development of obesity in childhood and adolescence.AIM. The aim of the study was to investigate the relationship between PON-1 polymorphism (rs662) and changes in the content of adipokines, myokines, and blood lipid metabolism in children and adolescents of different sexes with obesity.MATERIALS AND METHODS. In 100 healthy children and adolescents of different sexes and 89 of their peers with obesity, a genetic study was conducted to assess the single nucleotide polymorphism of the PAO-1 (rs662) genes. In blood serum, total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol, triacylglycerols, glucose and aminotransferase activity (alanine aminotransferase and aspartate aminotransferase) were determined by photometric methods, as well as leptin, adiponectin, resistin, apelin, irisin, adipsin, myostatin, FGF21, osteocrine, oncostatin and insulin — by multiplex ELISA, and asprosin — by ELISA ones.RESULTS. The patients with the homozygous Arg192/Arg allele, the development of complications of obesity in boys is limited and their occurrence in girls is prevented. In other variants of PON-1 polymorphism (Gln192/Gln and Gln192/Arg genotypes), protective mechanisms are formed in the body of girls aimed at preventing complications in obesity. In boys with the Gln192/Gln genotype, obesity reveals more pronounced shifts in lipid metabolism, manifestations of alteration and an increase in the mass of adipose tissue, and in boys-carriers of the heterozygous Gln192/Arg allele, atherogenesis processes increase.CONCLUSION. Polymorphism of the paraoxonase-1 gene (rs662) contributes to the appearance of gender differences in changes in the content of adipokines and myokines in the blood during obesity in childhood and adolescence.

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Neuroprotective Roles of Apelin-13 in Neurological Diseases

Cited by 13 publications

References 136 publications

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants

The Fetal Alcohol Spectrum Disorders—An Overview of Experimental Models, Therapeutic Strategies, and Future Research Directions

The content of adipokines and myokines in the blood of children and adolescents with different genotypes according to the polymorphism rs662 of the paraoxonase-1 gene

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