Neuroprotective Role of Quercetin against Arsenic Induced Oxidative Stress in Rat Brain

Nirankari, Shveta; Kamal, Rozy; Dhawan, D. K.

doi:10.4172/2161-0525.1000359

Cited by 9 publications

(6 citation statements)

References 57 publications

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“…Arsenic administration for 21 days caused a significant increase of lipid peroxidation ( p < 0.05) as indicated by the increase of MDA level in the brain of mice compared with control mice ( Figure 6 ). The increased level of peroxidation confirmed the development of oxidative stress which was similar to those reported earlier [ 25 , 26 ]. Co-treatment with ANPP showed a significant reduction of the elevated lipid peroxidation ( p < 0.05).…”

Section: Resultssupporting

confidence: 90%

“…ANPP prevented the arsenic-induced reduction of acetylcholinesterase in the brain of mice. The neuroprotective effect of ANPP was very similar to that of the polyphenoloic compounds curcumin, quercetin and catechin [ 24 , 25 , 26 ]. These results suggest that ANPP has potential ability to reverse the reduction of acetylcholinesterase in arsenic treated mice.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the recent strategy in the management of arsenic toxicity is the use of antioxidant to combat arsenic-induced oxidative stress-mediated tissue damage [ 22 , 23 ]. Natural antioxidants such as catechin, quercetin and curcumin have shown protective effects against arsenic induced neurotoxicity [ 24 , 25 , 26 ]. Polyphenols are naturally occurring antioxidants that confer many health benefits.…”

Section: Introductionmentioning

confidence: 99%

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Polyphenolics with Strong Antioxidant Activity from Acacia nilotica Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice

et al. 2022

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Neurotoxicity is a serious health problem of patients chronically exposed to arsenic. There is no specific treatment of this problem. Oxidative stress has been implicated in the pathological process of neurotoxicity. Polyphenolics have proven antioxidant activity, thereby offering protection against oxidative stress. In this study, we have isolated the polyphenolics from Acacia nilotica and investigated its effect against arsenic-induced neurotoxicity and oxidative stress in mice. Acacia nilotica polyphenolics prepared from column chromatography of the crude methanol extract using diaion resin contained a phenolic content of 452.185 ± 7.879 mg gallic acid equivalent/gm of sample and flavonoid content of 200.075 ± 0.755 mg catechin equivalent/gm of sample. The polyphenolics exhibited potent antioxidant activity with respect to free radical scavenging ability, total antioxidant activity and inhibition of lipid peroxidation. Administration of arsenic in mice showed a reduction of acetylcholinesterase activity in the brain which was counteracted by Acacia nilotica polyphenolics. Similarly, elevation of lipid peroxidation and depletion of glutathione in the brain of mice was effectively restored to normal level by Acacia nilotica polyphenolics. Gallic acid methyl ester, catechin and catechin-7-gallate were identified in the polyphenolics as the major active compounds. These results suggest that Acacia nilotica polyphenolics due to its strong antioxidant potential might be effective in the management of arsenic induced neurotoxicity.

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Section: Resultssupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polyphenolics with Strong Antioxidant Activity from Acacia nilotica Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice

et al. 2022

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“…The natural dietary flavonoid shows a protective role against CNS-insult-induced neurodegeneration. Quercetin is a natural flavonoid that inhibits neuronal apoptotic cell death (Bureau et al, 2008; Yang et al, 2014; Lei et al, 2015; Kanter et al, 2016; Shveta et al, 2016). Interestingly, quercetin also regulated the mitochondrial apoptotic pathway and prevented the activation of Cyto.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that quercetin attenuates manganese-induced neurotoxicity by preventing neuroinflammation-mediated neurodegeneration, which it accomplishes via regulating the heme oxygenase-1 (HO-1)/nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kB) pathway (Bahar et al, 2017). Furthermore, it has been found that quercetin has a neuroprotective effect against neurodegeneration in various in vitro and in vivo mouse models (Bureau et al, 2008; Yang et al, 2014; Lei et al, 2015; Pogacnik et al, 2016; Shveta et al, 2016). The present study was conducted to explore the neuroprotective effect of quercetin against LPS-induced neuroinflammation-mediated neurodegeneration in the adult mouse cortex and hippocampus.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

et al. 2018

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Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. Lipopolysaccharide (LPS) is an essential component of the gram-negative bacterial cell wall and acts as a potent stimulator of neuroinflammation that mediates neurodegeneration. Quercetin is a natural flavonoid that is abundantly found in fruits and vegetables and has been shown to possess multiple forms of desirable biological activity including anti-inflammatory and antioxidant properties. This study aimed to evaluate the neuroprotective effect of quercetin against the detrimental effects of LPS, such as neuroinflammation-mediated neurodegeneration and synaptic/memory dysfunction, in adult mice. LPS [0.25 mg/kg/day, intraperitoneally (I.P.) injections for 1 week]-induced glial activation causes the secretion of cytokines/chemokines and other inflammatory mediators, which further activate the mitochondrial apoptotic pathway and neuronal degeneration. Compared to LPS alone, quercetin (30 mg/kg/day, I.P.) for 2 weeks (1 week prior to the LPS and 1 week cotreated with LPS) significantly reduced activated gliosis and various inflammatory markers and prevented neuroinflammation in the cortex and hippocampus of adult mice. Furthermore, quercetin rescued the mitochondrial apoptotic pathway and neuronal degeneration by regulating Bax/Bcl2, and decreasing activated cytochrome c, caspase-3 activity and cleaving PARP-1 in the cortical and hippocampal regions of the mouse brain. The quercetin treatment significantly reversed the LPS-induced synaptic loss in the cortex and hippocampus of the adult mouse brain and improved the memory performance of the LPS-treated mice. In summary, our results demonstrate that natural flavonoids such as quercetin can be beneficial against LPS-induced neurotoxicity in adult mice.

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Arsenic-induced oxidative stress, cholinesterase activity in the brain of Swiss albino mice, and its amelioration by antioxidants Vitamin E and Coenzyme Q10

Sharma

Kshetrimayum

Sadhu

et al. 2018

Environ Sci Pollut Res

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Arsenic toxicity becomes one of the major public health issues in several countries. Chronic and acute exposure to arsenic has been reported to be toxic to various systems of the human body and also observed in controlled experimental studies. The study was conducted to evaluate the neurotoxic effect of arsenic in Swiss albino mice and its amelioration by Vitamin E, Coenzyme Q10 and their combination. Swiss albino mice were treated with arsenic of 136 ppm for 15 days. The daily dose is 1/3 of LD 50 (acute) reported dose of arsenic. Thereafter, the animals were maintained either on drinking water or treated with Vitamin E (50 mg/kg bwt), Coenzyme Q10 (10 mg/kg bwt), and their combination by i.p.daily for 15 days. After the treatment, animals were sacrificed. The weight of the brain was marginally lower (ns), in arsenic-treated group as compared to control and antioxidant-protected groups. The LPO (lipid peroxidation) level was higher in arsenic-treated group, and this elevation was checked to some extent by the selected antioxidants which were statistically significant in combination of antioxidant-protected group. A significant reduction was found in GSH (reduced glutathione) level in the brain of arsenic-treated mice whereas GSH level was considerably higher in antioxidant-protected groups. Further, total thiol and total protein level were lower in arsenic-treated group. However, total thiol was significantly higher in antioxidant-protected groups. CAT (catalase) activity was significantly lower while SOD (superoxide dismutase) activity was marginally lowered in arsenic-treated group, and it was slightly higher in antioxidant-protected groups. Further, reduction in AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) and motor coordination activity were also observed in arsenic-treated groups. Whereas, a higher AChE, BChE, and motor coordination activity was observed in antioxidant-protected group. These data indicate a positive role of selected antioxidant against the toxicity of arsenic in the brain of mice.

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Neuroprotective Role of Quercetin against Arsenic Induced Oxidative Stress in Rat Brain

Cited by 9 publications

References 57 publications

Polyphenolics with Strong Antioxidant Activity from Acacia nilotica Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice

Polyphenolics with Strong Antioxidant Activity from Acacia nilotica Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

Arsenic-induced oxidative stress, cholinesterase activity in the brain of Swiss albino mice, and its amelioration by antioxidants Vitamin E and Coenzyme Q10

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