Neuroprotective properties of Cantharellus cibarius polysaccharide fractions in different in vitro models of neurodegeneration

Lemieszek, Marta Kinga; Nunes, Fernando M.; Cardoso, Cláudia Andréa Lima; Marques, Guilhermina; Rzeski, Wojciech

doi:10.1016/j.carbpol.2018.06.038

Cited by 33 publications

(15 citation statements)

References 66 publications

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“…SH-SY5Y cells' differentiation to the neuronal cells was performed according to the previously described method, but the experiments were conducted on neuronal cells cultured for 12 days [56].…”

Section: Differentiation Of Sh-sy5y Towards Neuronal Cellsmentioning

confidence: 99%

Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice

Andres-Mach

Szewczyk

Zagaja

et al. 2021

IJMS

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Status epilepticus (SE) is a frequent medical emergency that can lead to a variety of neurological disorders, including cognitive impairment and abnormal neurogenesis. The aim of the presented study was the in vitro evaluation of potential neuroprotective properties of a new pyrrolidine-2,5-dione derivatives compound C11, as well as the in vivo assessment of the impact on the neurogenesis and cognitive functions of C11 and levetiracetam (LEV) after pilocarpine (PILO)-induced SE in mice. The in vitro results indicated a protective effect of C11 (500, 1000, and 2500 ng/mL) on astrocytes under trophic stress conditions in the MTT (3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide) test. The results obtained from the in vivo studies, where mice 72 h after PILO SE were treated with C11 (20 mg/kg) and LEV (10 mg/kg), indicated markedly beneficial effects of C11 on the improvement of the neurogenesis compared to the PILO control and PILO LEV mice. Moreover, this beneficial effect was reflected in the Morris Water Maze test evaluating the cognitive functions in mice. The in vitro confirmed protective effect of C11 on astrocytes, as well as the in vivo demonstrated beneficial impact on neurogenesis and cognitive functions, strongly indicate the need for further advanced molecular research on this compound to determine the exact neuroprotective mechanism of action of C11.

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Section: Differentiation Of Sh-sy5y Towards Neuronal Cellsmentioning

confidence: 99%

Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice

Andres-Mach

Szewczyk

Zagaja

et al. 2021

IJMS

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“…The polysaccharides isolated from the fruiting bodies of C. cibarius were galactans and glucans, including a novel linear 3-O-methylated galactan and a new heteropolysaccharide. These macromolecules showed a wide range of biological activities, such as antioxidant, antitumor, antiproliferative, immunomodulatory and neuroprotective properties [80][81][82][83][84][85][86]. Mittermeier et al [87] investigated the taste active and taste modulating compounds from this mushroom by LC-MS and 1D/2D-NMR experiments and identified several C18-acetylenic acids:…”

Section: Cantharellus Cibarius Frmentioning

confidence: 99%

“…Cantharellus cibarius Fr. (Cantharellaceae) Polysaccharide [85,86] Extract [92] Polysaccharide [80,82] Polysaccharide (immunomodulatory [81,86] and neuroprotective activities [85])…”

Section: Thelephora Ganbajun M Zangmentioning

confidence: 99%

Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

et al. 2020

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Mushrooms have a long history of uses for their medicinal and nutritional properties. They have been consumed by people for thousands of years. Edible mushrooms are collected in the wild or cultivated worldwide. Recently, mushroom extracts and their secondary metabolites have acquired considerable attention due to their biological effects, which include antioxidant, antimicrobial, anti-cancer, anti-inflammatory, anti-obesity, and immunomodulatory activities. Thus, in addition to phytochemists, nutritionists and consumers are now deeply interested in the phytochemical constituents of mushrooms, which provide beneficial effects to humans in terms of health promotion and reduction of disease-related risks. In recent years, scientific reports on the nutritional, phytochemical and pharmacological properties of mushroom have been overwhelming. However, the bioactive compounds and biological properties of wild edible mushrooms growing in Southeast Asian countries have been rarely described. In this review, the bioactive compounds isolated from 25 selected wild edible mushrooms growing in Southeast Asia have been reviewed, together with their biological activities. Phytoconstituents with antioxidant and antimicrobial activities have been highlighted. Several evidences indicate that mushrooms are good sources for natural antioxidants and antimicrobial agents

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“…At present, there is no effective treatment for AD. More and more evidence indicates that natural polysaccharides extracted from animals and plants possess a range of biological activities, for example, they exhibit antioxidant properties [11], and are used for neurodegenerative diseases [12]. In the previous work, a polysaccharide named PRG was isolated from the medicinal fungus Phellinus ribis .…”

Section: Introductionmentioning

confidence: 99%

Optimization of Degradation Conditions with PRG, a Polysaccharide from Phellinus ribis, by RSM and the Neuroprotective Activity in PC12 Cells Damaged by Aβ25–35

et al. 2019

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In the previous work, we found PRG, a polysaccharide from Phellinus ribis, exhibited neurotrophic activity. To obtain an active structural unit with lower molecular weight, PRG was degraded to prepare the degraded PRG (DPRG) using ascorbic acid and H2O2. The aim of the paper was to obtain DPRG by optimizing the degradation conditions using response surface methodology (RSM) and to study its protective effects of PC12 cells induced by Aβ25–35. The optimum conditions were as follows; the concentration of H2O2-Vc was 17 mM and degradation temperature was 50 °C; when degradation time was 1.6 h, the experimental response value of PC12 cell viability was 83.4 ± 0.15%, which was in accordance with the predicted value (83.5%). We also studied the protective effects of DPRG against the Aβ25–35-induced neurotoxicity and explored the underlying mechanism. The results showed that treatment with DPRG could attenuate PC12 cells death. The mechanism was relative to the inhibition of cell apoptosis by increasing the MMP level and decreasing the protein expression of cytochrome C (Cytc) in PC12 cells. In conclusion, DPRG with lower molecular weight was obtained successfully. It possessed neuroprotective properties and might be a candidate for neurodegenerative disease treatment.

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Neuroprotective properties of Cantharellus cibarius polysaccharide fractions in different in vitro models of neurodegeneration

Cited by 33 publications

References 66 publications

Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice

Preclinical Assessment of a New Hybrid Compound C11 Efficacy on Neurogenesis and Cognitive Functions after Pilocarpine Induced Status Epilepticus in Mice

Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

Optimization of Degradation Conditions with PRG, a Polysaccharide from Phellinus ribis, by RSM and the Neuroprotective Activity in PC12 Cells Damaged by Aβ25–35

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