Neuroprotective Potentials of Alstonia boonei Extracts on Biochemical Markers of Brain Integrity in Experimental Rats

Abstract

The brain is a complex and extremely important part of the body. It functions through neurons and neuroglia, sending out as well as receiving and interpreting simple and complex signals in the body. 1 Neurons can be injured in the course of action through various physiological mechanisms. When this happens, Acute signals are sent to the neuroglia which has the capacity and function of destroying the or repairing the injured neurons. This action represents physiological neuroprotective response by the neuroglia and helps to preserve neuronal action. 1 Neurodegeneration is a normal physiological process in brain ageing. It is equally a consequence of several neurological disorders. Cerebrovascular disease has become a leading cause of death globally with increasing prevalence. 2 Neuropsychiatric and neurodegenarative disorders abound today. These include but not limited to parkinsonism, multiple sclerosis, stroke, orofacial dyskinensis, dementia, epilepsy, cerebrovascular impairment, depression, alzheimers disease (AD) etc. These could be lifelong and life threatening. 3 Neurological disorders are usually debilitating, incapacitating, lead to loss of vital functions and reduces significantly the individual's quality of life. There is need to protect the brain and indeed the central nervous system from damage due to acute injury or as a result of physiological mechanisms.

Protective Evaluation of feed fortified with Alstonia boonei and Mitracarpus scaber in African Catfish exposed to Aeromonas hydrophila: Clinicopathology and immunohistochemistry

“…boonei has been widely used in the terrestrial animals for the treatment of various diseases due to the presence of bioactive components in all parts of the plant. Studies have shown that the plant has antiin ammatory, anti-venom, anti-poison and antimicrobial properties and a potent compound in the treatment of ulcers which is commonly found in aeromonas infection (Akinmoladun et al, 2007;Ogueke et al, 2014;Ikechukwu et al, 2021). In the same vein, M. scaber also contains bioactive ingredients that are used as therapeutic agents and feed additives.…”