Neuroprotective Potential of Virgin Coconut Oil in abrogating Acrylamide-induced Neurobehavioural Impairment Via NRF-2/NFK-B Signaling and BDNF Upregulation
Ayodeji Johnson Ajibare,
Olabode Oluwadare Akintoye,
Adeola Isaac Oriyomi
et al.
Abstract:This study investigated the effects of virgin coconut oil-supplemented diet (VCO) on acrylamide (AA)-induced neurotoxicity in Wistar rats. Twenty (20) Wistar rats (18-250g) were grouped into four (I-IV) (n = 5): I: control, received the recommended feed and water daily, II: received oral doses of AA (10 mg/kg body weight (b.w)) alone, III: received oral doses of AA (10 mg/kg b.w) and 5% VCO, IV: received oral doses of AA (10 mg/kg b.w) and 10% VCO, for 56 days. On the 55th day, the rats were subjected to behav… Show more
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