Neuroprotective potential and phytochemical composition of acorn fruits

Gezici, Sevgi; Şekeroğlu, Nazım

doi:10.1016/j.indcrop.2018.10.082

Cited by 37 publications

(34 citation statements)

References 25 publications

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“…The extraction procedures were performed as described in our previous research. 13 Extraction yields of the methanol and water extracts of the rhizomes from turmeric were determined as 12.36% and 8.02% (w/w), respectively. The methods of used herein were summarized as graphical abstract in the Figure 2.…”

Section: Crude Extract Preparationmentioning

confidence: 99%

“…Phenolic compounds in total were determined in accordance with slightly modified Folin-Ciocalteau's method. 13,26 Absorption was measured at 760 nm at a using a 96-well microplate reader (VersaMax Molecular Devices, USA). Total flavonoid content of the extracts was calculated by aluminum chloride colorimetric method.…”

Section: Determination Of Total Polyphenolic Contentsmentioning

confidence: 99%

“…Total flavonoid content of the extracts was calculated by aluminum chloride colorimetric method. 13,27 A number of dilutions of quercetin were obtained to prepare a calibration curve. Absorbance of the reaction mixtures was measured at wavelength of 415 nm with a using a 96-well microplate reader (VersaMax Molecular Devices, USA).…”

Section: Determination Of Total Polyphenolic Contentsmentioning

confidence: 99%

“…In vitro antioxidant methods including 2,2-diphenyl-1picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6sulphonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and cupric ion reducing capacity (CUPRAC) were performed to reveal antioxidant activity of the extracts. 13,18,21,22 The extracts and commercial antioxidant standards were dissolved in DMSO at different concentrations, ranging from 100 μg mL −1 to 1000 μg mL −1 for the antioxidant assays.…”

Section: Antioxidant Activity Assaysmentioning

confidence: 99%

“…capacities by our research group. [12][13][14][15][16][17][18][19][20][21][22][23][24][25] The main purpose of these researches are to contribute to discover new and effective natural products for prevention and treatment of oxidative stress-related diseases and disorders. Take into consideration our previous researches on MAPs and plant-derived natural products, total polyphenolic contents, in vitro antioxidant effects, neuroprotective and anticancer activities of the extracts obtained from the rhizomes of C. longa L. were aimed to evaluate in the presented research.…”

Section: Introductionmentioning

confidence: 99%

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A study on Turmeric (Curcuma longa L.): Multifunctional agents for the management of oxidative damage, neurodegeneration and cancer

Gezici

2019

Curr. Res. Pharm. Sci.

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The rhizome of Curcuma longa L, (turmeric, curcumin) has been widely used in therapeutic purposes for acne, heal wound, prevent skin damage, reduce cholesterol, treat diabetes, and control blood pressure. From this point of view, this research was aimed to investigate its biological properties including antioxidant, anticancer and neuroprotective properties of the turmeric rhizomes. The rhizomes of turmeric were extracted with methanol-MeOH and distilled water-dH 2 O, and subjected to various assays. Neuroprotective potentials of the extracts were tested through enzyme inhibitory assays on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), which are closely linked to pathogenesis of Alzheimer's disease. Their anticancer activities were evaluated using MTT assay against A549, MCF-7, HeLa human cancer cells, and non-tumorous HUVECs. In vitro methods including 2,2diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and cupric ion reducing capacity (CUPRAC) were performed to reveal antioxidant capacities of the extracts. Total polyphenolic compositions of the extracts were also identified spectrophotometrically. The turmeric extracts were found to have rich polyphenolic quantities, particularly the MeOHextract possessed higher total polyphenolic contents than the dH 2 O-extract. The extracts demonstrated the remarkable inhibition on both of the cholinesterase enzymes even at the lowest concentration (100μg mL −1 ). Moreover, they showed higher enzyme inhibition against AChE, comparing with that of BChE enzyme. In general, a significant correlation was observed between the total antioxidant capacities and neuroprotective potentials of the extracts from turmeric rhizomes. As for the anticancer activity, the extracts were found as a natural anticancer agent with the IC 50 values ranged from 13.01±0.16 to 26.72±1.04 μg mL −1 . In the light of the findings of the presented research, it is clearly concluded that turmeric is an important natural source to fight oxidative stress related diseases, with its excellent cholinesterase-inhibiting properties; strong antioxidant capacities as well as remarkable anticancer activities.

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Section: Crude Extract Preparationmentioning

confidence: 99%

Section: Determination Of Total Polyphenolic Contentsmentioning

confidence: 99%

Section: Determination Of Total Polyphenolic Contentsmentioning

confidence: 99%

Section: Antioxidant Activity Assaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A study on Turmeric (Curcuma longa L.): Multifunctional agents for the management of oxidative damage, neurodegeneration and cancer

Gezici

2019

Curr. Res. Pharm. Sci.

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Therapeutic, Phytochemistry, and Pharmacology of Acorns (Quercus Nuts): A Review

Vinha

Barreira

Ferreira

et al. 2019

Reference Series in Phytochemistry

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The current global food system must adapt to the expected growth of world population. This adaptation will probably include an increased consumption of edible wild foods, due to their richness in micronutrients and bioactive compounds, besides providing a cost-effective and sustainable way of improving caloric food security. Acorns (Quercus nuts) have been presenting an important role on the rural economy. In fact, their nutritional value; high contents in bioactive compounds; biological activity such as antioxidant, anticarcinogenic, and cardioprotective properties; and use in the treatment of specific diseases such as atherosclerosis, diabetes, or Alzheimer's disease have raised the interest in

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Therapeutic, Phytochemistry, and Pharmacology of Acorns (Quercus Nuts): A Review

Vinha

Barreira

Ferreira

et al. 2020

Reference Series in Phytochemistry

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Neuroprotective potential and phytochemical composition of acorn fruits

Cited by 37 publications

References 25 publications

A study on Turmeric (Curcuma longa L.): Multifunctional agents for the management of oxidative damage, neurodegeneration and cancer

A study on Turmeric (Curcuma longa L.): Multifunctional agents for the management of oxidative damage, neurodegeneration and cancer

Therapeutic, Phytochemistry, and Pharmacology of Acorns (Quercus Nuts): A Review

Therapeutic, Phytochemistry, and Pharmacology of Acorns (Quercus Nuts): A Review

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