Neuroprotective efficacy of subcutaneous insulin-like growth factor-I administration in normotensive and hypertensive rats with an ischemic stroke

Central IGF‐I Receptors in the Brain are Instrumental to Neuroprotection by Systemically Injected IGF‐I in a Rat Model for Ischemic Stroke

“…The application of intranasal IGF‐I administration was effective, especially when administered early after the insult . Three studies revealed that systemic injection of IGF‐I also leads to neuroprotection . The current study proves for the first time that intravenously administered IGF‐I exerts neuroprotective actions via the direct interaction with its receptors in the brain.…”

Nonviral Reprogramming Genes Accelerate Formation of Neurons from Murine Embryonic Brain Cells: Synergistic Effect of Brain Derived Neurotrophic Factor Gene Therapy

“…Numerous reports suggested that BDNF [31], GDNF [32], FGF [33] and IGF [34] have neuroprotective utilities and endorse neuroplasticity beneficial for neuropsychiatric diseases [4,26]. Growth factor-activated stem cells were accelerated by the stromal signals for iPSC reprogramming of human myeloid progenitors [40].…”

“…Since our data suggested that reprogramming genes themselves can speed up transformation of embryonic brain cells into neuron cells, and the trophic factors BDNF have demonstrated neuroprotective actions in a number of animal models [4,26,[31][32][33][34], we wondered what effects on neuron cell formations, especially impacts on producing amounts of reprogrammed neuron cells, if combing reprogrammed stem cells as the cell replacement therapy with BDNF as the gene therapy. Two of the critical factors for successful stem cell therapy are to increase in speediness and quantity of producing neuron cells.…”

Therapeutically Targeting Neuroinflammation and Microglia after Acute Ischemic Stroke

“…Four days following MCAO, IL-10T mice showed a 40% reduction in infarct size that was associated with significantly reduced levels of active caspase 3 compared with wild-type mice [72]. Subcutaneous administration of IGF-1 also resulted in significantly reduced infarct volumes and an increase in motor-sensory functions in normotensive rats [73]. …”