Neuroprotective effects of α-lipoic acid against hypoxic– ischemic brain injury in neonatal rats

Mei, Xiaohan; Yang, Youwen

doi:10.4314/tjpr.v16i5.12

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…The animal experiment was approved by the Ethical Committee of Taihe Hospital, Hubei University of Medicine (approval no. HU-14/2014-03), and the animals were handled in line with the guidelines stipulated by NIH (MA, USA) [10].…”

Section: Animalsmentioning

confidence: 99%

“…It acts as a cofactor for many enzymes. It possesses very good metal ion-chelating property due to the presence of two sulfhydryl groups, and it exhibits free radicalscavenging/quenching activity owing to the presence of free hydroxyl groups in its structure [9,10]. Alpha-lipoic acid (ALA) has attracted a lot of research interest owing to its potent antioxidant activity and its anti-lipid peroxidation, anti-inflammatory, immunomodulatory, antiallergic, antidiabetic, antitumor, wound-healing, cardioprotective, renoprotective, neuroprotective and hepatoprotective properties [10 -12].…”

Section: Introductionmentioning

confidence: 99%

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Norcantharidin alleviates cyclophosphamide induced immunosuppression and leukopenia in mice through NF κB pathway

Jiang¹,

Liao²,

Wang³

et al. 2023

Trop. J. Pharm Res

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Purpose: To investigate the beneficial effect of alpha-lipoic acid (ALA) during pregnancy and lactation on susceptibility to ovalbumin (OVA)-induced neonatal asthma, and the mechanism of involved.Methods: Pregnant BALB/c mice were administered ALA (1 % mixed with mouse chow) or standard mouse chow from 6th day of gestation to 21st day of lactation (postnatal). The offspring (neonatal pups) from the OVA and ALA+OVA groups were sensitized on 1st, 7th and 14th postnatal days (PNDs) via intraperitoneal (i.p.) injection of OVA (0.5 μg). Control mice pups were not exposed to OVA. On PND 21, all pubs were again exposed to 1 % OVA aerosol using a nebulizer.Results: Neonatal mice exposed to ALA showed a significant decline (p < 0.05) in the number of inflammatory cells (eosinophils), levels of inflammatory markers (IL-4, IL-13, IL-5 and TNF-α) as well as OVA-specific IgE and total IgE, when compared to neonatal mice from pregnant mice that did not receive ALA (control). Moreover, the antioxidant profiles of ALA-treated mice offspring were significantly improved (p < 0.05). Marked downregulation (p < 0.05) of the protein expressions of NF-κB p-p65 subunit and TNF-α were observed in ALA-treated mice pups.Conclusion: ALA exposure during pregnancy (maternal exposure) markedly decreases OVA-induced asthmatic airway inflammatory response in pups. Thus, ALA might be beneficial for use along with standard anti-asthmatic drugs in the management of pediatric asthmatic patients

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Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Norcantharidin alleviates cyclophosphamide induced immunosuppression and leukopenia in mice through NF κB pathway

Jiang¹,

Liao²,

Wang³

et al. 2023

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…ALA has a low molecular weight (206.32 Da) and can cross biological membranes, including the blood-brain barrier. Some studies demonstrated that ALA acted as an effective neuroprotector in mice models [82,83]. Sharma et al [84] reported that lycopene (a bright red carotenoid) can decrease both PE and FGR risks, but Antartani et al [85] found that only FGR risk was decreased.…”

Section: Potential Antioxidant-based Therapy For Adverse Pregnancy Outcomesmentioning

confidence: 99%

Effect of Endogenic and Exogenic Oxidative Stress Triggers on Adverse Pregnancy Outcomes: Preeclampsia, Fetal Growth Restriction, Gestational Diabetes Mellitus and Preterm Birth

Joo

Kim

et al. 2021

IJMS

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Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) in cells and tissues and the ability of a biological system to detoxify them. During a normal pregnancy, oxidative stress increases the normal systemic inflammatory response and is usually well-controlled by the balanced body mechanism of the detoxification of anti-oxidative products. However, pregnancy is also a condition in which this adaptation and balance can be easily disrupted. Excessive ROS is detrimental and associated with many pregnancy complications, such as preeclampsia (PE), fetal growth restriction (FGR), gestational diabetes mellitus (GDM), and preterm birth (PTB), by damaging placentation. The placenta is a tissue rich in mitochondria that produces the majority of ROS, so it is important to maintain normal placental function and properly develop its vascular network to ensure a safe and healthy pregnancy. Antioxidants may ameliorate these diseases, and related research is progressing. This review aimed to determine the association between oxidative stress and adverse pregnancy outcomes, especially PE, FGR, GDM, and PTB, and explore how to overcome this oxidative stress in these unfavorable conditions.

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Benefits of α‑lipoic acid in high‑risk pregnancies (Review)

et al. 2021

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α-Lipoic acid (ALA) is a natural molecule that is inconsistently synthesized by the human body and must be provided from exogenous sources, such as food and dietary supplements. Once absorbed, the oxidized form of ALA is transformed into its reduced form, dihydrolipoic acid (DHLA). ALA/DHLA exert direct and indirect antioxidant, anti-inflammatory and fine immunomodulatory effects. ALA/DHLA reduce the levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-8 and IL-17), while increasing the secretion of anti-inflammatory cytokines (IL-10). They also inhibit cyclooxygenase 2, thereby decreasing the secretion of prostaglandin E2 and nitrogen oxide, and reducing the risk of miscarriage in the first trimester of pregnancy. In patients at risk of abortion, administration of ALA from the first trimester has shown efficacy by accelerating subchorionic hematoma resorption, with a significant decrease in the accompanying abdominal pain. ALA has been proven to be efficient in maintaining the length of the cervix and keeping it closed following one episode of premature labor. Preeclampsia is a dysfunction caused by abnormal placentation and an excessive maternal inflammatory response, leading to extreme hypoxia in the placental bed and exaggerated oxidative stress, with release of oxygen free radicals. Oxidative stress plays a key role in the development of preeclampsia and intrauterine growth restriction. The hypothesis of antioxidant supplementation may play an essential part in disease prevention and fetal neuroprotection. Contents1. Introduction 2. ALA/DHLA action 3. ALA impact on high-risk pregnancies 4. Conclusions

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Neuroprotective effects of α-lipoic acid against hypoxic– ischemic brain injury in neonatal rats

Cited by 4 publications

References 26 publications

Norcantharidin alleviates cyclophosphamide induced immunosuppression and leukopenia in mice through NF κB pathway

Norcantharidin alleviates cyclophosphamide induced immunosuppression and leukopenia in mice through NF κB pathway

Effect of Endogenic and Exogenic Oxidative Stress Triggers on Adverse Pregnancy Outcomes: Preeclampsia, Fetal Growth Restriction, Gestational Diabetes Mellitus and Preterm Birth

Benefits of α‑lipoic acid in high‑risk pregnancies (Review)

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