Neuroprotective effects of water-soluble Ganoderma lucidum polysaccharides on cerebral ischemic injury in rats

Zhou, Ziyi; Tang, Yuping; Xiang, Jun; Wua, Pin; Jin, Hongyue; Wang, Zhong; Mori, Masao; Cai, Dingfang

doi:10.1016/j.jep.2010.06.023

Cited by 83 publications

(51 citation statements)

References 39 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Lingzhi), one of the most popular medicinal fungi with a long history in oriental countries, has been extensively used in the treatment of a variety of diseases including cancer, hyperlipidemia, diabetes, neurasthenia, insomnia, hypertension and chronic hepatopathy [10,11]. Ganoderma lucidum polysaccharide (Gl-PS), a glycopeptide isolated from the water-soluble polysaccharides of Ganoderma lucidum, is the primary effective component of Ganoderma lucidum [12][13][14]. Our and some others' previous studies have demonstrated that Gl-PS administration significantly prevented the progression of diabetic renal complications and attenuated myocardial collagen cross-linking and AGEs in diabetic rats, by exerting greater antioxidative activity [15,16].…”

Section: Introductionmentioning

confidence: 99%

Ganoderma LucidumPolysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes

Tie

Yang

An³

et al. 2012

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims. Refractory wounds in diabetic patients constitute a serious complication that often leads to amputation with limited treatment regimens. The present study was designed to determine the protective effect of Ganoderma lucidum polysaccharide (Gl-PS) on diabetic wound healing and investigate underlying mechanisms. Methods. Streptozotocin (STZ)-induced type 1 diabetic mice with full-thickness excisional wounds were intragastrically administered with 10, 50 or 250 mg/kg/day of Gl-PS. Results. Gl-PS dose-dependently rescued the delay of wound closure in diabetic mice. 50 and 250 mg/kg/day of Gl-PS treatment significantly increased the mean perfusion rate around the wound in diabetic mice. Diabetic conditions markly increased mitochondrial superoxide anion (O₂·^-) production, nitrotyrosine formation, and inducible nitric oxide synthase (iNOS) activity in wound tissues, which were normalized with Gl-PS treatment. In diabetic wound tissues, the protein level of manganese superoxide dismutase (MnSOD) was unchanged whereas MnSOD activity was inhibited and its nitration was potentiated; Gl-PS administration suppressed MnSOD nitration and increased MnSOD and glutathione peroxidase (GPx) activities. Moreover, Gl-PS attenuated the redox enzyme p66Shc expression and phosphorylation dose-dependently in diabetic mice skin. Conclusion. Gl-PS rescued the delayed wound healing and improved wound angiogenesis in STZ-induced type 1 diabetic mice, at least in part, by suppression of cutaneous MnSOD nitration, p66Shc and mitochondrial oxidative stress.

show abstract

Section: Introductionmentioning

confidence: 99%

Ganoderma LucidumPolysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes

Tie

Yang

An³

et al. 2012

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Polysaccharides, which have been isolated from G. lucidum fruting bodies, have been reported to possess antioxidant [32], immunomodulatory [33], and antitumour characteristics [34]. Moreover, these polysaccharides have also been reported to have protective effects against cerebral ischaemic injury [35]. G. lucidum may mediate neuronal functions by modulating the activities of different signalling pathways.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats

Gökçe

Kahveci

Atanur³

et al. 2015

Injury

View full text Add to dashboard Cite

“…Recent studies have confirmed I/R injury might cause acute ischemic stroke, local cerebral cell injury or death with manifestations of neurological deficit symptoms and local infarction [23]. It is well known that oxidative metabolism is essential for the survival of brain, but is also associated with the generation of ROS.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of ginkgolide K against acute ischemic stroke on middle cerebral ischemia occlusion in rats

Yin

Chen

et al. 2011

J Nat Med

View full text Add to dashboard Cite

Ginkgolide K, a natural platelet-activating factor receptor antagonist, was isolated from the leaves of Ginkgo biloba. However, little is known about its neuroprotective effect in ischemia-reperfusion (I/R)-induced cerebral injury. Hence, the present study was carried out to investigate the effect of ginkgolide K on neuroprotection and the potential mechanisms in the rat I/R model induced by middle cerebral artery occlusion (MCAO). The rats were pretreated with ginkgolide K 2, 4 and 8 mg/kg (i.v.) once a day for 5 days before MCAO. Neurological deficit score (NDS), brain water content, 2,3,5-triphenyltetrazolium chloride (TTC) staining and pathology of brain tissue, as well as indexes of oxidative stress [superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and nitric oxide synthase (NOS)] were measured at 24 h after ischemia. The results indicated that pretreatment with ginkgolide K significantly diminished the volume of infarction and brain water content, and improved NDS. Moreover, ginkgolide K markedly reversed the level of MDA, NO, NOS and SOD to their normal state in serum or cerebral ischemic section. In addition, hematoxylin and eosin staining showed the neuronal injury was significantly improved after being pretreated with ginkgolide K. These findings demonstrate that ginkgolide K exhibits neuroprotective properties through its antioxidative action in MCAO rats.

show abstract

Neuroprotective effects of water-soluble Ganoderma lucidum polysaccharides on cerebral ischemic injury in rats

Cited by 83 publications

References 39 publications

Ganoderma LucidumPolysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes

Ganoderma LucidumPolysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial Oxidative Stress in Type 1 Diabetes

Neuroprotective effects of Ganoderma lucidum polysaccharides against traumatic spinal cord injury in rats

Neuroprotective effect of ginkgolide K against acute ischemic stroke on middle cerebral ischemia occlusion in rats

Contact Info

Product

Resources

About